Ahern JR, Whitney KD (2014) Sesquiterpene lactone stereochemistry influences herbivore resistance and plant fitness in the field. Ann Bot 113:731–740. https://doi.org/10.1093/aob/mct297

Article  CAS  PubMed  Google Scholar 

Bernardes ACFPF, Matosinhos RC, Araújo MCPM, Barros CH, Soares RDOA, Costa DC, Sachs D, Saúde-Guimarães DA (2021) Sesquiterpene lactones from Lychnophora species: antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout. J Ethnopharmacol 269:113738. https://doi.org/10.1016/j.jep.2020.113738

Article  CAS  PubMed  Google Scholar 

Borsato MLC, Grael CFF, Souza GEP, Lopes NP (2000) Analgesic activity of the lignans from Lychnophora ericoides. Phytochemistry 55:809–813. https://doi.org/10.1016/S0031-9422(00)00388-5

Article  CAS  PubMed  Google Scholar 

Collevatti RG, Rabelo SG, Vieira RF (2009) Phylogeography and disjunct distribution in Lychnophora ericoides (Asteraceae), an endangered cerrado shrub species. Ann Bot 104:655–664. https://doi.org/10.1093/aob/mcp157

Article  PubMed  PubMed Central  Google Scholar 

Crotti AEM, Lopes JLC, Lopes NP (2005) Triple quadrupole tandem mass spectrometry of sesquiterpene lactones: a study of goyazensolide and its congeners. J Mass Spectrom 40:1030–1034. https://doi.org/10.1002/jms.877

Article  CAS  PubMed  Google Scholar 

Cunha WR, Lopes JLC, Vichnewski W, Díaz JG, Herz W (1995) Eremantholides and a guaianolide from Lychnophora rupestris. Phytochemistry 39:387–389. https://doi.org/10.1016/0031-9422(94)00945-P

Article  CAS  Google Scholar 

Depieri LV, Praça FSG, Campos PM, Bentley MVLB (2015) Advances in the bioanalytical study of drug delivery across the skin. Ther Deliv 6(5):571–294. https://doi.org/10.4155/tde.15.20

Article  CAS  PubMed  Google Scholar 

Franz TJ (1975) Percutaneous absorption. On the relevance of in vitro data. J Invest Dermatol 64:190–195. https://doi.org/10.1111/1523-1747.ep12533356

Article  CAS  PubMed  Google Scholar 

Gobbo-Neto L, Santos MD, Kanashiro A, Almeida MC, Lucisano-Valim YM, Lopes JLC, Souza GEP, Lopes NP (2005) Evaluation of the anti-inflammatory and antioxidant activities of di-C-glucosylflavones from Lychnophora ericoides (Asteraceae). Planta Med 71:3–6. https://doi.org/10.1055/s-2005-837742

Article  CAS  PubMed  Google Scholar 

Gobbo-Neto L, Guaratini T, Pessoa C, Moraes MO, Costa-Lotufo LV, Vieira RF, Colepicolo P, Lopes NP (2010) Differential metabolic and biological profiles of Lychnophora ericoides Mart. (Asteraceae) from different localities in the Brazilian ‘Campos Rupestres’. J Braz Chem Soc 21:750–759. https://doi.org/10.1590/S0103-50532010000400023

Article  CAS  Google Scholar 

Goodwin RJA, Nilsson A, Borg D, Langridge-Smith PRR, Harrison DJ, Mackay CL, Iverson SL, Andrén PE (2012) Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation. J Proteom 75:4912–4920. https://doi.org/10.1016/j.jprot.2012.07.006

Article  CAS  Google Scholar 

Gratieri T, Gelfuso GM, Lopez RFV (2008) Basic principles and applications of iontophoresis for cutaneous penetration of drugs. Quim Nova 31:1490–1498. https://doi.org/10.1590/S0100-40422008000600040

Article  CAS  Google Scholar 

Handler AM, Fallah M, Pedersen AJ, Pedersen GP, Nielsen KT, Janfelt C (2020) MALDI mass spectrometry imaging as a complementary analytical method for improved skin distribution analysis of drug molecule and excipients. Int J Pharm 590:119949. https://doi.org/10.1016/j.ijpharm.2020.119949

Article  CAS  PubMed  Google Scholar 

Keles LC, Melo NI, Aguiar GP, Wakabayashi KAL, Carvalho CE, Cunha WR, Crotti AEM, Lopes JLC, Lopes NP (2010) Lychnophorinae (Asteraceae): a survey of its chemical constituents and biological activities. Quim Nova 33:2245–2260. https://doi.org/10.1590/S0100-40422010001000038

Article  CAS  Google Scholar 

Lopes NP, Stark CBW, Hong H, Gates PJ, Staunton J (2001) A study of the effect of pH, solvent system, cone potential and the addition of crown ethers on the formation of the monensin protonated parent ion in electrospray mass spectrometry. Analyst 126:1630–1632. https://doi.org/10.1039/b106852k

Article  CAS  Google Scholar 

Lopes NP, Stark CBW, Gates PJ, Staunton J (2002) Fragmentation studies on monensin A by sequential electrospray mass spectrometry. Analyst 127:503–506. https://doi.org/10.1039/b110412h

Article  CAS  PubMed  Google Scholar 

Marinho BM, Guimarães VHD, Moraes DS, Ribeiro GHM, Silva RM, Lopes NP, Guimarães ALS, Paula AMB, Santos SHS (2023) Lychnophora ericoides Mart. (Brazilian arnica) ethanol extract accelerates the skin wound healing process: evidence for its mechanism of action. Phytomedicine 119:155000. https://doi.org/10.1016/j.phymed.2023.155000

Article  CAS  PubMed  Google Scholar 

Marinho BM, Lescano CH, Santos SHS (2024) Brazilian arnicas: bioactive compounds, pharmacological properties, potential use and clinical applications. Phytochem Rev 23:245–280. https://doi.org/10.1007/s11101-023-09884-x

Article  CAS  Google Scholar 

Moreira EA, Pilon AC, Andrade LE, Lopes NP (2018) New perspectives on chlorogenic acid accumulation in harvested leaf tissue: impact on traditional medicine preparations. ACS Omega 3:18380–18386. https://doi.org/10.1021/acsomega.8b02409

Article  CAS  Google Scholar 

Pafili A, Meikopoulos T, Kontogiannidou E, Papageorgiou S, Demiri E, Meimari D, Fatouros DG, Gika H, Theodoridis G (2021) Development and validation of LC-MS/MS method for the determination of UV-filters across human skin in vitro. J Chromatogr B Analyt Technol Biomed Life Sci 1167:122561. https://doi.org/10.1016/j.jchromb.2021.122561

Article  CAS  PubMed  Google Scholar 

Paulsen E (2023) The sesquiterpene lactone mix: a review of past, present and future aspects. Contact Dermat 89:434–441. https://doi.org/10.1111/cod.14419

Article  Google Scholar 

Pavarini DP, Nogueira EF, Callejon DR, Soares DM, Souza GEP, Cunha FQ, Lopes JLC, Lopes NP (2013) Novel bisabolane derivative from ‘arnica-da-serra’ (Vernonieae: Asteraceae) reduces pro-nociceptive cytokines levels in LPS-stimulated rat macrophages. J Ethnopharmacol 148:993–998. https://doi.org/10.1016/j.jep.2013.05.003

Article  CAS  Google Scholar 

Rüngeler P, Castro V, Mora G, Gören N, Vichnewski W, Pahl HL, Merfort I, Schmidt TJ (1999) Inhibition of transcription factor NF-ΚB by sesquiterpene lactones: a proposed molecular mechanism of action. Bioorg Med Chem 7:2343–2352. https://doi.org/10.1016/S0968-0896(99)00195-9

Article  PubMed  Google Scholar 

Sakamoto HT, Flausino D, Castellano EE, Stark CBW, Gates PJ, Lopes NP (2003) Sesquiterpene lactones from Lychnophora ericoides. J Nat Prod 66:693–695. https://doi.org/10.1021/np020314v

Article  CAS  PubMed  Google Scholar 

Santos PA, Amarante MFC, Pereira AMS, Bertoni B, França SC, Pessoa C, Moraes MO, Costa-Lotufo LV, Pereira MRP, Lopes NP (2004) Production of an antiproliferative furanoheliangolide by Lychnophora ericoides cell culture. Chem Pharm Bull 52:1433–1435. https://doi.org/10.1248/cpb.52.1433

Article  Google Scholar 

Santos MD, Gobbo-Neto L, Albarella L, Souza GEP, Lopes NP (2005) Analgesic activity of di-caffeoylquinic acids from roots of Lychnophora ericoides (arnica-da-serra). J Ethnopharmacol 96:545–549. https://doi.org/10.1016/j.jep.2004.09.043

Article  CAS  PubMed  Google Scholar 

Santos MD, Chen G, Almeida MC, Soares DM, Souza GEP, Lopes NP, Lantz RC (2010) Effects of caffeoylquinic acid derivatives and C-flavonoid from Lychnophora ericoides on in vitro inflammatory mediator production. Nat Prod Commun 5:733–740. https://doi.org/10.1177/1934578x1000500512

Article  PubMed  PubMed Central  Google Scholar 

Semir J, Rezende AR, Monge M, Lopes NP (2011) As Arnicas endêmicas das serras do Brasil. Editora UFOP, Ouro Preto, pp 90–102

Google Scholar 

Silva DB, Turatti ICC, Gouveia DR, Ernst M, Teixeira SP, Lopes NP (2014) Mass spectrometry of flavonoid vicenin-2, based sunlight barriers in Lychnophora species. Sci Rep 4:4309. https://doi.org/10.1038/srep04309

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silva R, Lopes NP, Silva DB (2016) Application of MALDI Mass Spectrometry in natural products analysis. Planta Med 82:671–689. https://doi.org/10.1055/s-0042-104800