An Investigation of In Vitro Anti-Cancer Efficacy of Dihydroartemisinin-Loaded Bovine Milk Exosomes Against Triple-Negative Breast Cancer

López-Gómez M, et al. Cancer in developing countries: the next most preventable pandemic. Glob Prob Cancer. 2013;88(1):117–22.

Google Scholar 

Unger-Saldaña KJWjoco. Challenges to the early diagnosis and treatment of breast cancer in developing countries. 2014;5(3):465.

Yvonne E. Breast cancer. 2021. [cited 2024]; Available from: https://www.who.int/news-room/fact-sheets/detail/breast-cancer. Accessed 27 Feb 2024.

Breast Cancer Statistics And Resources. 2024. [cited 2024]; Available from: https://www.bcrf.org/breast-cancer-statistics-and-resources/. Accessed 27 Feb 2024.

Chaudhuri A, et al. Endorsement of TNBC biomarkers in precision therapy by nanotechnology. Cancers. 2023;15(9):2661.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaudhuri A, et al. Emergence of nanotechnology as a powerful cavalry against triple-negative breast cancer (TNBC). Pharmaceuticals. 2022;15(5):542.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pandey P, et al. Engineered nanomaterials as an effective tool for HER2+ breast cancer therapy. Drug Discov Today. 2022;27(9):2526–40.

Article  CAS  PubMed  Google Scholar 

Mustacchi G, De Laurentiis M. The role of taxanes in triple-negative breast cancer: literature review. Drug Des Devel Ther. 2015;9:4303–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yadav BS, et al. Systemic treatment strategies for triple-negative breast. World  J Clin Oncol. 2014;5(2):125.

DiMasi JA, Grabowski HG. Economics of new oncology drug development. J Clinical Oncol. 2007;25(2):209–16.

Article  Google Scholar 

Aggarwal S, et al. Drug repurposing for breast cancer therapy: old weapon for new battle. Semin Cancer Biol. 2021;68:8–20.

Article  CAS  PubMed  Google Scholar 

Jansen FH. The pharmaceutical death-ride of dihydroartemisinin. Malar J. 2010;9(1):212.

Dai X, et al. Dihydroartemisinin: a potential natural anticancer drug. Int J Biol Sci. 2021;17(2):603.

Morris CA, et al. Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration. Malar J. 2011;10:1–7.

Price R, et al. Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives. Am J Trop Med Hyg. 1999;60:547–55.

Article  CAS  PubMed  Google Scholar 

Wong KH, et al. Development of nanoscale drug delivery systems of dihydroartemisinin for cancer therapy: a review. Asian J Pharm Sci. 2022;17(4):475–90.

Article  PubMed  PubMed Central  Google Scholar 

Agrawal AK, et al. Milk-derived exosomes for oral delivery of paclitaxel. Nanomed: Nanotech Biol Med. 2017;13(5):1627–1636.

Aqil F, et al. Exosomal delivery of berry anthocyanidins for the management of ovarian cancer. Food Funct. 2017;8(11):4100–7.

Article  CAS  PubMed  Google Scholar 

Aqil F, et al. Exosomal formulation enhances therapeutic response of celastrol against lung cancer. Exp Mol Pathol. 2016;101(1):12–21.

Article  CAS  PubMed  Google Scholar 

Aqil F, et al. Exosomes for the enhanced tissue bioavailability and efficacy of curcumin. AAPS J. 2017;19:1691–702.

Article  CAS  PubMed  Google Scholar 

Aqil F, et al. Milk exosomes-natural nanoparticles for siRNA delivery. Cancer Lett. 2019;449:186–95.

Article  CAS  PubMed  Google Scholar 

Kandimalla R, et al. Targeted oral delivery of paclitaxel using colostrum-derived exosomes. Cancers. 2021;13(15):3700.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar DN, et al. Exosomes as emerging drug delivery and diagnostic modality for breast cancer: recent advances in isolation and application. Cancers. 2022;14(6):1435.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar DN, et al. Combination therapy comprising paclitaxel and 5-fluorouracil by using folic acid functionalized bovine milk exosomes improves the therapeutic efficacy against breast cancer. Life. 2022;12(8):1143.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar DN, et al. Impact of the drug loading method on the drug distribution and biological efficacy of exosomes. AAPS PharmSciTech. 2023;24(6):166.

Article  CAS  PubMed  Google Scholar 

Munagala R, et al. Exosomal formulation of anthocyanidins against multiple cancer types. Cancer Lett. 2017;393:94–102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kowal J, Tkach M, Théry CJ. Biogenesis and secretion of exosomes. Curr Opin Cell Biol. 2014;29:116–25.

Article  CAS  PubMed  Google Scholar 

Urimi D, et al. Polyglutamic acid functionalization of chitosan nanoparticles enhances the therapeutic efficacy of insulin following oral administration. AAPS PharmSciTech. 2019;20:1–14.

Article  Google Scholar 

Kumar DN, et al. Enhanced therapeutic efficacy against melanoma through exosomal delivery of hesperidin. Mol Pharm. 2024;21(6):3061–76.

Article  CAS  PubMed  Google Scholar 

Costa A, Scholer-Dahirel A, Mechta-Grigoriou F. The role of reactive oxygen species and metabolism on cancer cells and their microenvironment. Semin Cancer Bbiol. 2014;25:23–32.

Wylie PG, Bowen WP. Determination of cell colony formation in a high-content screening assay. Clin Lab Med. 2007;27(1):193–9.

Article  PubMed  Google Scholar 

Kyakulaga AH, et al. Withaferin A inhibits epithelial to mesenchymal transition in non-small cell lung cancer cells. Sci Rep. 2018;8(1):15737.

Munagala R, et al. Bovine milk-derived exosomes for drug delivery. Cancer Lett. 2016;371(1):48–61.

Article  CAS  PubMed  Google Scholar 

Gong C, et al. Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy. J Nanobiotechnol. 2019;17:1–8.

Article  CAS  Google Scholar 

He Q, et al. Tumor microenvironment responsive drug delivery systems. Asian J Pharm Sci. 2020;15(4):416–48.

Article  PubMed  Google Scholar 

Chary PS, et al. Enhancing breast cancer treatment: comprehensive study of gefitinib-loaded poloxamer 407/TPGS mixed micelles through design, development, in-silico modelling, In-Vitro testing, and Ex-Vivo characterization. Int J Pharm. 2024;657:124109.

Article  CAS  PubMed  Google Scholar 

McKelvey KJ, et al. Exosomes: mechanisms of uptake. J Circ Biomark. 2015;4:7.

Sartaj A, et al. Exploring the therapeutic potential of nanostructured lipid carrier approaches to tackling the inherent lacuna of chemotherapeutics and herbal drugs against breast cancer. J Drug Delivery Sci Technol. 2021;63:102451.

Solaini G, et al. Evaluating mitochondrial membrane potential in cells. Biosci Rep. 2007;27(1–3):11–21.

Article  CAS  PubMed  Google Scholar 

de Sá Junior PL, et al. The roles of ROS in cancer heterogeneity and therapy. Oxidative Med Cell Longev. 2017;2017(1):2467940.

Kalyanaraman B. Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species. Biochem Soc Trans. 2011;39(5):1221–5.

Chary PS, et al. Design, fabrication and evaluation of stabilized polymeric mixed micelles for effective management in cancer therapy. Pharm Res. 2022;39(11):2761–80.

Article  CAS  PubMed  Google Scholar 

Bantsimba-Malanda C, et al. Calcium signal modulation in breast cancer aggressiveness. Cell Calcium. 2023;113:102760.

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