The State of Synthetic Cannabinoid Medications for the Treatment of Pain

Pollio A. The name of cannabis: a short guide for nonbotanists. Cannabis Cannabinoid Res. 2016;1(1):234–8.

Article  PubMed  PubMed Central  Google Scholar 

Alves VL, et al. The synthetic cannabinoids phenomenon: from structure to toxicological properties. A review. Crit Rev Toxicol. 2020;50(5):359–82.

Article  CAS  PubMed  Google Scholar 

Mouslech Z, Valla V. Endocannabinoid system: an overview of its potential in current medical practice. Neuro Endocrinol Lett. 2009;30(2):153–79.

CAS  PubMed  Google Scholar 

Hillard CJ. Circulating endocannabinoids: from whence do they come and where are they going? Neuropsychopharmacology. 2018;43(1):155–72.

Article  CAS  PubMed  Google Scholar 

Shevyrin V, et al. On a new cannabinoid classification system: a sight on the illegal market of novel psychoactive substances. Cannabis Cannabinoid Res. 2016;1(1):186–94.

Article  CAS  Google Scholar 

Di Marzo V. New approaches and challenges to targeting the endocannabinoid system. Nat Rev Drug Discov. 2018;17(9):623–39.

Article  PubMed  Google Scholar 

Di Marzo V. The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders. Dialogues Clin Neurosci. 2020;22(3):259–69.

Article  PubMed  PubMed Central  Google Scholar 

Pertwee RG, et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol Rev. 2010;62(4):588–631.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown JD, et al. Natural and synthetic cannabinoids: pharmacology, uses, adverse drug events, and drug interactions. J Clin Pharmacol. 2021;61(Suppl 2):S37–52.

CAS  PubMed  Google Scholar 

Morales P, Reggio PH. An update on non-CB(1), non-CB(2) cannabinoid related g-protein-coupled receptors. Cannabis Cannabinoid Res. 2017;2(1):265–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vučković S, et al. Cannabinoids and pain: new insights from old molecules. Front Pharmacol. 2018;9:1259.

Article  PubMed  PubMed Central  Google Scholar 

Oz M, Yang KS, Mahgoub MO. Effects of cannabinoids on ligand-gated ion channels. Front Physiol. 2022;13:1041833.

Article  PubMed  PubMed Central  Google Scholar 

Zou S, Kumar U. Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system. Int J Mol Sci. 2018;19(3):833.

Article  PubMed  PubMed Central  Google Scholar 

An D, et al. Targeting cannabinoid receptors: current status and prospects of natural products. Int J Mol Sci. 2020;21(14):5064.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lowe H, et al. The endocannabinoid system: a potential target for the treatment of various diseases. Int J Mol Sci. 2021;22(17):9472.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, et al. Decarboxylation study of acidic cannabinoids: a novel approach using ultra-high-performance supercritical fluid chromatography/photodiode array-mass spectrometry. Cannabis Cannabinoid Res. 2016;1(1):262–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atakan Z. Cannabis, a complex plant: different compounds and different effects on individuals. Ther Adv Psychopharmacol. 2012;2(6):241–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atalay S, Jarocka-Karpowicz I, Skrzydlewska E. Antioxidative and anti-inflammatory properties of cannabidiol. Antioxidants (Basel). 2019;9(1):21.

Article  PubMed  Google Scholar 

U.S. Food & Drug Administration. FDA and cannabis: research and drug approval process. 2023. https://www.fda.gov/news-events/public-health-focus/fda-and-cannabis-research-and-drug-approval-process.

Crocq MA. History of cannabis and the endocannabinoid system. Dialogues Clin Neurosci. 2020;22(3):223–8.

Article  PubMed  PubMed Central  Google Scholar 

National Library of Medicine. 2023. https://clinicaltrials.gov/.

Burstein SH. Ajulemic acid: potential treatment for chronic inflammation. Pharmacol Res Perspect. 2018;6(2): e00394.

Article  PubMed  PubMed Central  Google Scholar 

Mechoulam R, et al. Early phytocannabinoid chemistry to endocannabinoids and beyond. Nat Rev Neurosci. 2014;15(11):757–64.

Article  CAS  PubMed  Google Scholar 

Pertwee RG. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol. 2009;156(3):397–411.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pertwee RG. Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci. 2005;76(12):1307–24.

Article  CAS  PubMed  Google Scholar 

Tamba BI, et al. Challenges and opportunities in preclinical research of synthetic cannabinoids for pain therapy. Medicina (Kaunas). 2020;56(1):24.

Article  PubMed  Google Scholar 

Hollinshead SP, et al. Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain. J Med Chem. 2013;56(14):5722–33.

Article  CAS  PubMed  Google Scholar 

Stebulis JA, et al. Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells. Life Sci. 2008;83(19–20):666–70.

Article  CAS  PubMed  Google Scholar 

Kumawat VS, Kaur G. Therapeutic potential of cannabinoid receptor 2 in the treatment of diabetes mellitus and its complications. Eur J Pharmacol. 2019;862: 172628.

Article  CAS  PubMed  Google Scholar 

Ladha KS, et al. Perioperative Pain and Addiction Interdisciplinary Network (PAIN): consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users by a modified Delphi process. Br J Anaesth. 2021;126(1):304–18.

Article  PubMed  Google Scholar 

Shah S, et al. ASRA Pain Medicine consensus guidelines on the management of the perioperative patient on cannabis and cannabinoids. Reg Anesth Pain Med. 2023;48(3):97–117.

Article  PubMed  Google Scholar 

Wiley JL, Marusich JA, Huffman JW. Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids. Life Sci. 2014;97(1):55–63.

Article  CAS  PubMed  Google Scholar 

Atwood BK, et al. JWH018, a common constituent of “Spice” herbal blends, is a potent and efficacious cannabinoid CB receptor agonist. Br J Pharmacol. 2010;160(3):585–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif