Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment

Thompson AM, Bizzarro MJ. Necrotizing enterocolitis in newborns: pathogenesis, prevention and management. Drugs. 2008;68(9):1227–38.

Article  CAS  PubMed  Google Scholar 

Jones IH, Hall NJ. Contemporary outcomes for infants with necrotizing enterocolitis—a systematic review. J Pediatr. 2020;220(86–92): e3.

Google Scholar 

Ballance WA, Dahms BB, Shenker N, Kliegman RM. Pathology of neonatal necrotizing enterocolitis: a ten-year experience. J Pediatr. 1990;117(1 Pt 2):S6-13.

Article  CAS  PubMed  Google Scholar 

Lim JC, Golden JM, Ford HR. Pathogenesis of neonatal necrotizing enterocolitis. Pediatr Surg Int. 2015;31(6):509–18.

Article  PubMed  Google Scholar 

Bazacliu C, Neu J. Pathophysiology of necrotizing enterocolitis: an update. Curr Pediatr Rev. 2019;15(2):68–87.

Article  PubMed  Google Scholar 

Anand KJS, Stevens BJ, McGrath PJ. Pain in neonates and infants: pain research and clinical management series. Elsevier Health Sciences; 2007.

Google Scholar 

Strigo IA, Bushnell CM, Boivin M, Duncan GH. Psychophysical analysis of visceral and cutaneous pain in human subjects. Pain. 2002;97(3):235–46.

Article  PubMed  Google Scholar 

Koenen LR, Icenhour A, Forkmann K, Pasler A, Theysohn N, Forsting M, et al. Greater fear of visceral pain contributes to differences between visceral and somatic pain in healthy women. Pain. 2017;158(8):1599–608.

Article  PubMed  Google Scholar 

Strigo IA, Duncan GH, Boivin M, Bushnell MC. Differentiation of visceral and cutaneous pain in the human brain. J Neurophysiol. 2003;89(6):3294–303.

Article  PubMed  Google Scholar 

Ten Barge JA, Vermeulen MJ, Simons SHP, van den Bosch GE. Pain management for necrotizing enterocolitis: getting the balance right. Pediatr Res. 2022;92(5):1423–31.

Article  PubMed  PubMed Central  Google Scholar 

van Ganzewinkel C, Been JV, Verbeek I, van der Loo TB, van der Pal SM, Kramer BW, Andriessen P. Pain threshold, tolerance and intensity in adolescents born very preterm or with low birth weight. Early Hum Dev. 2017;110:31–8.

Article  PubMed  Google Scholar 

Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161(9):1976–82.

Article  PubMed  PubMed Central  Google Scholar 

Gibbins S, Maddalena P, Moulsdale W, Garrard F, Jan Mohamed T, Nichols A, Asztalos E. Pain assessment and pharmacologic management for infants with NEC: a retrospective chart audit. Neonatal Netw. 2006;25(5):339–45.

Article  PubMed  Google Scholar 

Imren C, Vlug LE, de Koning BAE, Diertens T, Snel HE, Suurland J, et al. Necrotizing enterocolitis in a Dutch cohort of very preterm infants: prevalence, mortality, and long-term outcomes. Eur J Pediatr Surg. 2022;32(1):111–9.

Purves D. Neuroscience. 6th ed. New York: Oxford University Press; 2018.

Google Scholar 

Boezaart AP, Smith CR, Chembrovich S, Zasimovich Y, Server A, Morgan G, et al. Visceral versus somatic pain: an educational review of anatomy and clinical implications. Reg Anesth Pain Med. 2021;46(7):629–36.

Article  PubMed  Google Scholar 

Petrosyan M, Guner YS, Williams M, Grishin A, Ford HR. Current concepts regarding the pathogenesis of necrotizing enterocolitis. Pediatr Surg Int. 2009;25(4):309–18.

Article  PubMed  Google Scholar 

Nino DF, Sodhi CP, Hackam DJ. Necrotizing enterocolitis: new insights into pathogenesis and mechanisms. Nat Rev Gastroenterol Hepatol. 2016;13(10):590–600.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark DA, Thompson JE, Weiner LB, McMillan JA, Schneider AJ, Rokahr JE. Necrotizing enterocolitis: intraluminal biochemistry in human neonates and a rabbit model. Pediatr Res. 1985;19(9):919–21.

Article  CAS  PubMed  Google Scholar 

Ng PC. An update on biomarkers of necrotizing enterocolitis. Semin Fetal Neonatal Med. 2018;23(6):380–6.

Article  PubMed  Google Scholar 

Tarracchini C, Milani C, Longhi G, Fontana F, Mancabelli L, Pintus R, et al. Unraveling the microbiome of necrotizing enterocolitis: insights in novel microbial and metabolomic biomarkers. Microbiol Spectr. 2021;9(2): e0117621.

Article  PubMed  Google Scholar 

Peiris M, Bulmer DC, Baker MD, Boundouki G, Sinha S, Hobson A, et al. Human visceral afferent recordings: preliminary report. Gut. 2011;60(2):204–8.

Article  PubMed  Google Scholar 

Su X, Gebhart GF. Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J Neurophysiol. 1998;80(5):2632–44.

Article  CAS  PubMed  Google Scholar 

Grundy L, Erickson A, Brierley SM. Visceral pain. Annu Rev Physiol. 2019;10(81):261–84.

Article  Google Scholar 

McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, et al. Ex vivo study of human visceral nociceptors. Gut. 2018;67(1):86–96.

Article  CAS  PubMed  Google Scholar 

Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN. A P2X purinoceptor expressed by a subset of sensory neurons. Nature. 1995;377(6548):428–31.

Article  CAS  PubMed  Google Scholar 

Cook SP, McCleskey EW. Cell damage excites nociceptors through release of cytosolic ATP. Pain. 2002;95(1–2):41–7.

Article  CAS  PubMed  Google Scholar 

Burnstock G. Purinergic receptors. J Theor Biol. 1976;62(2):491–503.

Article  CAS  PubMed  Google Scholar 

Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature. 1995;377(6548):432–5.

Article  CAS  PubMed  Google Scholar 

Bradbury EJ, Burnstock G, McMahon SB. The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci. 1998;12(4–5):256–68.

Article  CAS  PubMed  Google Scholar 

Gonzalez-Cano R, Montilla-Garcia A, Perazzoli G, Torres JM, Canizares FJ, Fernandez-Segura E, et al. Intracolonic mustard oil induces visceral pain in mice by TRPA1-dependent and -independent mechanisms: role of tissue injury and P2X receptors. Front Pharmacol. 2020;11: 613068.

Article  CAS  PubMed  Google Scholar 

Brierley SM, Carter R, Jones W 3rd, Xu L, Robinson DR, Hicks GA, et al. Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice. J Physiol. 2005;567(Pt 1):267–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wirkner K, Sperlagh B, Illes P. P2X3 receptor involvement in pain states. Mol Neurobiol. 2007;36(2):165–83.

Article  CAS  PubMed  Google Scholar 

Robinson DR, McNaughton PA, Evans ML, Hicks GA. Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling. Neurogastroenterol Motil. 2004;16(1):113–24.

Article  CAS  PubMed  Google Scholar 

Xu GY, Huang LY. Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons. J Neurosci. 2002;22(1):93–102.

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif