Bajorath J. Pharmacophore. Encyclopaedia of Cancer 2017, pp.2849–2852.

Sahdev AK, Gupta P, Manral K, Rana P, Singh A. An overview on pharmacophore: their significance and importance for the activity of drug design. Res J Pharmac Tech. 2023;16(3):1496–502. https://doi.org/10.52711/0974-360X.2023.00246.

Article  Google Scholar 

Baig MH, Ahmad K, Roy S, Ashraf JM, Adil M, Sidiqqui MH, et al. Computer aided drug design: success and limitations. Curr Pharmaceut Desig. 2016;22:572–81. https://doi.org/10.2174/1381612822666151125000550.

Article  CAS  Google Scholar 

Williams DP, Naisbitt DJ. Toxicophores: groups and metabolic routes associated with increased safety risk. Curr Opin Drug Discor. 2002;5(1):104–15. PMID: 11865664.

CAS  Google Scholar 

Sharma B, Chenthamarakshan V, Dhurandhar A, Pereira S, Hendler JA, Dordik JS, et al. Accurate clinical toxicity prediction using multi-task deep neural nets and contrastive molecular explanations. Sci Rep. 2023;13:4908. https://doi.org/10.1038/s41598-023-31169-8.

Tonini M, Lipolina L, Poluzzi E, Cremas F, Corazza GR, De Ponti F. Review article: clinical limitations of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther. 2004;19:379–90. https://doi.org/10.1111/j.1365-2036.2004.01867.x.

De Ponti F. Pharmacology of serotonin: what a clinician should know. Gut 53 (10): https://doi.org/10.1136/gut2003.035568.

Che J, Wang Z, Sheng H, Huang F, Dong X, Hu T, et al. Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents. R Soc Open Sci. 2018;5(7):1–11. https://doi.org/10.1098/rsos.180176.

Article  CAS  Google Scholar 

Dror O, Scheidman-Duhovny D, Inbar Y, Nussinov R, Wolfsm HJ. A novel approach for efficient pharmacophore-based virtual screening: method and applications. J Chem Inf Model. 2009;49(10):2333–43. https://doi.org/10.1021/ci900263d.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He G, Gong B, Li J, Song T, Li S, Lu X. An improved receptor-based pharmacophore generation algorithm guided by atomic chemical characteristics and hybridization types. Front Pharmacol.2018; 9(1463): 1–9. | https://doi.org/10.3389/fphar.2018.01463.

AbdEl Fattah LI, Zickri MB, Aal LA, Heikal O, Osama E, et al. The effect of thymoquinone, α7 receptor agonist and α7 receptor allosteric modulator on the cerebral cortex in experimentally induced Alzheimer’s disease in relation to MSCs activation. Int J Stem Cells. 2016;9(2):230–8. https://doi.org/10.15283/ijsc16021.

Article  CAS  PubMed Central  Google Scholar 

Unal G, Erdogan B. Neuroprotective effects of thymoquinone against ketamine –and MK-801-induced neurotoxicity in SH-SY5Y cells: from the perspective of glutamatergic dysfunction in schizophremia. Clin Exp Health Sci. 2020;10(2):178–82. https://doi.org/10.33808/clinexphealthsci.734422.

Article  CAS  Google Scholar 

De Santis E, Minicozzi V, Rossi G, Stellato F, Morante S. Is styrene competitive for dopamine receptor binding? J Biomol Concept. 2022;13(1):200–6. https://doi.org/10.1515/bmc-2022-0016.

Article  CAS  Google Scholar 

Gopal KV, Wu C, Moore EJ, Gross W. Assessment of styrene oxide neurotoxicity using in vitro auditory cortex networks. ISRN Otolaryngol. 2011;204804. https://doi.org/10.5402/2011/204804.

Dipple A, Levy LS, Lawley PD. Comparative carcinogenicity of alkylating agents: comparisons of a series of alkyl and aralkyl bromides of differing chemical reactivities as inducers of sarcoma at the site of a single injection. rat Carcinog. 1981;2(2):103–7. https://doi.org/10.1093/carcin/2.2.103.

Dogne JM, Rolin S, de Leval X, Benoit P, Neven P, Delarge J, et al. Pharmacology of the thromboxane receptor antagonist and thromboxane synthase inhibitor BM-531. Cardiovasc Drug Rev. 2001;19(2):87–96. https://doi.org/10.1111/j.1527-3466.2001.tb00057.x.

Mozaffari S, Nikfar S, Abdollahi M. Efficacy and tolerability of renzapride in irritable bowel syndrome: a meta-analysis of randomized, controlled clinical trials including 2528 patients. Arch Med Sci. 2014;10(1):10–8. https://doi.org/10.5114/aoms.2014.40729.

Article  CAS  PubMed  PubMed Central  Google Scholar 

DiPalma JR. Metoclopramide: a dopamine receptor antagonist. Am Fam Physician. 1990;41(3):919–24. PMID: 2407079.

CAS  PubMed  Google Scholar 

Nisijima K, Yoshino T, Yui K, Katoh S. Potent serotonin (5-HT) (2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. Brain Res. 2001;890(1):23–31. https://doi.org/10.1016/s0006-8993(00)03020-1.

Article  CAS  PubMed  Google Scholar 

Orr MJ, Cao AB, Wang CT, Gaisin A, Csakai A, Friswold AP, et al. Discovery of highly potent serotonin 5-HT2 receptor agonists inspired by heteroyohimbine natural products. ACS Med Chem Lett. 2022;13(4):648–57. https://doi.org/10.1021/acsmedchemlett.1c00694.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elahi B, Phielipp N, Chen R. N-Methyl-D-Aspartate antagonista in levodopa induced dyskinesia: a meta-analysis. Can J Neurol Sci. 2012;39(4):465–72. https://doi.org/10.1017/s0317167100013974.

Article  PubMed  Google Scholar 

Suzuki H, Gen K, Inoue Y. Comparison of the anti-dopamine D2 and anti-serotonin 5-HT (2A) activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotic parent compounds and metabolites thereof. J Psychopharmacol. 2013;27(4):396–400. Epub 2013 Feb 20.

Article  CAS  PubMed  Google Scholar 

Broadly KJ, Kelly DR. Muscarinic receptor agonists and antagonists. Molecules. 2001;6(3):142–93. https://doi.org/10.3390/60300142.

Article  Google Scholar 

Abbott FV, Hellemans KGC. Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects. Behav Brain Res. 2000;112(1–2):177–86. https://doi.org/10.1016/s0166-4328(00)00179-0.

Article  CAS  PubMed  Google Scholar 

Otero R, Seoane S, Sigueiro R, Belorusova AY, Maestro MA, Perez-Fernandez R. Carborane-based design of a potent vitamin D receptor agonist. Chem Sci. 2016;7(2):1033–7. https://doi.org/10.1039/c5sc03084f.

Article  CAS  PubMed  Google Scholar 

Rajpal RK, Ross B, Rajpal SD, Hoang K. Bromfenac ophthalmic solution for the treatment of postoperative ocular pain and inflammation: safety, efficacy, and patient adherence. Patient Prefer Adherence. 2014;8:925–31. https://doi.org/10.2147/PPA.S46667.

Article  PubMed  PubMed Central  Google Scholar 

Ma L, Zhou Y, Yang D, Wang M-W, Lu W, Jin J. Synthesis of hydantoin androgen receptor antagonists and study on their antagonistic activity. Molecules. 2022;27(18):5867. https://doi.org/10.3390/molecules27185867.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Pearce RA. Effects of halothane on GABA(A) receptor kinetics: evidence for slowed agonist unbinding. J Neurosci. 2000;20(3):899–907. https://doi.org/10.1523/JNEUROSCI.20-03-00899.2000.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giovannitti JA, Thoms SM, Crawford JJ. Alpha-2 adrenergic receptor agonists: a review of current clinical applications. Anesth Prog. 2015;62(1):31–8. https://doi.org/10.2344/0003-3006-62.1.31.

Article  PubMed  PubMed Central  Google Scholar 

Scholler-Gyure M, Kakuda TN, De Smedt G, Vanaken H, Bouche MP, Peeters M, et al. A pharmacokinetic study of etravirine (TMC125) co-administered with ranitidine and omeprazole in HIV-negative volunteers. Br J Clin Pharmacol. 2008;66(4):508–16. https://doi.org/10.1111/j.1365-2125.2008.03214.x. Epub 2008 Apr 25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nielsen ST. Binding of [3H]ICIA 5165, an H2-receptor antagonist to guinea pig gastric mucosa. Agent Act. 1986;18(5–6):524–31. https://doi.org/10.1007/BF01964958.

Article  CAS  Google Scholar 

Asra R, Jones AM. Green electrosynthesis of drug metabolites. Toxicol Res (Camb). 2023;12(2):150–77. https://doi.org/10.1093/toxres/tfad009.

Article  PubMed  Google Scholar 

Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S. Paracetamol: new vistas of an old drug. CNS Drug Rev. 2006;12(3–4):250–75. https://doi.org/10.1111/j.1527-3458.2006.00250.x.

Article  CAS  PubMed  Google Scholar 

`Roca-Vinardell A, Berrocoso E, Llorca-Torralb M, Garcia-Partida JA, Gibert-Rahola J, Mico JA. Involvement of 5-HT1A/1B receptor in the antinociceptive effect of Paracetamol in the rat formalin test. Neurobiol Pain. 2018;3:15–21. https://doi.org/10.1016/j.ynpai.2018.01.004.

Article  CAS  PubMed  Google Scholar 

Wang M, Peng B, Wang GY, Zhao N, Xiong Z. Multiresidue analysis of tetracycline and β-receptor agonists in chicken by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry: comparison with QuE ChERS extraction method and ultrasound assisted extraction. J Food Comp Analys. 2019;85:103339. https://doi.org/10.1016/j.jfca.2019.103339.

Article