Hybrid derivatives containing dimethyl fumarate and benzothiazole scaffolds for the potential treatment of multiple sclerosis; in silico & in vivo study

Aliomrani M, Sahraian MA, Shirkhanloo H, Sharifzadeh M, Khoshayand M, Ghahremani MH. Correlation between heavy metal exposure and GSTM1 polymorphism in Iranian multiple sclerosis patients. Neurol Sci. 2017;38(7):1271.

Article  PubMed  Google Scholar 

Aliomrani M, Sahraian MA, Shirkhanloo H, Sharifzadeh M, Khoshayand MR, Ghahremani MH. Blood concentrations of cadmium and lead in multiple sclerosis patients from Iran. Iran J Pharm Res: IJPR. 2016;15(4):825.

CAS  PubMed  PubMed Central  Google Scholar 

Vollmer T, Signorovitch J, Huynh L, Galebach P, Kelley C, DiBernardo A, et al. The natural history of brain volume loss among patients with multiple sclerosis: a systematic literature review and meta-analysis. J Neurol Sci. 2015;357(1–2):8–18.

Article  PubMed  Google Scholar 

Eskandarieh S, Allahabadi NS, Sadeghi M, Sahraian MA. Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015. BMC Neurol. 2018;18(1):15.

Article  PubMed  PubMed Central  Google Scholar 

Ransohoff RM, Hafler DA, Lucchinetti CF. Multiple sclerosis—a quiet revolution. Nat Rev Neurol. 2015;11(3):134.

Article  PubMed  PubMed Central  Google Scholar 

Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol. 2005;23:683–747.

Article  CAS  PubMed  Google Scholar 

Crayton HJ, Rossman HS. Managing the symptoms of multiple sclerosis: a multimodal approach. Clin Ther. 2006;28(4):445–60.

Article  PubMed  Google Scholar 

Motl RW, Suh Y, Weikert M. Symptom cluster and quality of life in multiple sclerosis. J Pain Symptom Manage. 2010;39(6):1025–32.

Article  PubMed  Google Scholar 

Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, et al. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010;62(3):405–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F. Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. Lancet Neurol. 2016;15(10):1089–102.

Article  CAS  PubMed  Google Scholar 

Kuzmina US, Zainullina L, Vakhitov V, Bakhtiyarova K, Vakhitova YV. The Role of Glutamate in the Pathogenesis of Multiple Sclerosis. Neurosci Behav Physiol. 2020;50(6):669–75.

Article  CAS  Google Scholar 

Bissaro M, Moro S. Rethinking to riluzole mechanism of action: the molecular link among protein kinase CK1δ activity, TDP-43 phosphorylation, and amyotrophic lateral sclerosis pharmacological treatment. Neural Regen Res. 2019;14(12):2083.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheah B, Vucic S, Krishnan A, Kiernan M. Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr Med Chem. 2010;17(18):1942–59.

Article  CAS  PubMed  Google Scholar 

Nagoshi N, Nakashima H, Fehlings M. Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside. Molecules. 2015;20(5):7775–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doble A. The pharmacology and mechanism of action of riluzole. Neurology. 1996;47(6 Suppl 4):233S-S241.

Google Scholar 

Nourbakhsh B, Revirajan N, Waubant E. Association between glutamate blockade and fatigue in patients with multiple sclerosis. JAMA Neurol. 2015;72(11):1374–5.

Article  PubMed  Google Scholar 

Mills EA, Ogrodnik MA, Plave A, Mao-Draayer Y. Emerging understanding of the mechanism of action for dimethyl fumarate in the treatment of multiple sclerosis. Front Neurol. 2018;9:5.

Article  PubMed  PubMed Central  Google Scholar 

Gold R, Linker R, Stangel M. Fumaric acid and its esters: an emerging treatment for multiple sclerosis with antioxidative mechanism of action. Clin Immunol. 2012;142(1):44–8.

Article  CAS  PubMed  Google Scholar 

Huang H, Taraboletti A, Shriver LP. Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytes. Redox Biol. 2015;5:169–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao X, Sun G, Zhang J, Ting S-M, Gonzales N, Aronowski J. Dimethyl fumarate protects brain from damage produced by intracerebral hemorrhage by mechanism involving Nrf2. Stroke. 2015;46(7):1923–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Longbrake EE, Ramsbottom MJ, Cantoni C, Ghezzi L, Cross AH, Piccio L. Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients. Mult Scler J. 2016;22(8):1061–70.

Article  CAS  Google Scholar 

Yadav SK, Soin D, Ito K, Dhib-Jalbut S. Insight into the mechanism of action of dimethyl fumarate in multiple sclerosis. J Mol Med. 2019;97(4):463–72.

Article  CAS  PubMed  Google Scholar 

Liu Y, Yang T, Li H, Li MH, Liu J, Wang YT, et al. BD 750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK 3/STAT 5 signalling pathway. Br J Pharmacol. 2013;168(3):632–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hur W, Rosen H, Gray NS. A benzo [b] thiophene-based selective type 4 S1P receptor agonist. Bioorg Med Chem Lett. 2017;27(1):1–5.

Article  CAS  PubMed  Google Scholar 

Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, et al. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem. 1998;19(14):1639–62.

Article  CAS  Google Scholar 

Biovia DS. Discovery studio visualizer. San Diego, CA, USA. 2017.

Morris GM, Huey R, Olson AJ. Using autodock for ligand-receptor docking. Curr Protocol Bioinforma. 2008;24(1):8–14.

Article  Google Scholar 

Hyperchem H. Molecular modeling system. Hyper Cube: Inc and Auto Desk, Inc; 2002.

Google Scholar 

Gasteiger J, Marsili M. Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges. Tetrahedron. 1980;36(22):3219–28.

Article  CAS  Google Scholar 

Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem. 2009;30(16):2785–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Li J, Chen H, Zhang Y, Huang D. Synthesis and crystal structure of charge transfer complex (CTC) of 2-aminobenzothiazole with its Schiff Base. J Chem Crystallogr. 2011;41(12):1844–9.

Article  CAS  Google Scholar 

de Santana Nunes AK, Rapôso C, de Almeida Luna RL, da Cruz-Höfling MA, Peixoto CA. Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model. Cytokine. 2012;60(2):540–51.

Article  Google Scholar 

Mazloumfard F, Mirian M, Eftekhari S-M, Aliomrani M. Hydroxychloroquine effects on miR-155-3p and miR-219 expression changes in animal model of multiple sclerosis. Metab Brain Dis. 2020;35(8):1299–307.

Article  CAS  PubMed  Google Scholar 

Paknejad B, Shirkhanloo H, Aliomrani M. Is There Any Relevance Between Serum Heavy Metal Concentration and BBB Leakage in Multiple Sclerosis Patients? Biol Trace Elem Res. 2019;190(2):289–94.

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