Efficacy and safety of ticagrelor monotherapy following a brief DAPT vs. prolonged 12-month DAPT in ACS patients post-PCI: a meta-analysis of RCTs

Ibáñez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio AL, Crea F, Goudevenos J, Halvorsen S, Hindricks G, Kastrati A, Lenzen M, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimský P, Gale CP (2017) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 39(2):119–177. https://doi.org/10.1093/eurheartj/ehx393

Article  Google Scholar 

Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, Granger CB, Lange RA, Mack MJ, Mauri L, Mehran R, Mukherjee D, Newby LK, O’Gara PT, Sabatine MS, Smith PK, Smith SC (2016) 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention, 2011 ACCF/AHA guideline for coronary artery bypass graft surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable. Circulation. https://doi.org/10.1161/cir.0000000000000404

Article  PubMed  PubMed Central  Google Scholar 

Valgimigli M, Bueno H, Byrne RA, Collet J, Costa F, Jeppsson A, Jüni P, Kastrati A, Kolh P, Mauri L, Montalescot G, Neumann F, Petričević M, Roffi M, Steg PG, Windecker S, Zamorano JL, Levine GN, Badimon L, Kinnaird T (2017) 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. Eur Heart J 39(3):213–260. https://doi.org/10.1093/eurheartj/ehx419

Article  Google Scholar 

Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Rużyłło W, Gottlieb S, Neumann F, Ardissino D, De Servi S, Murphy SA, Riesmeyer JS, Weerakkody GJ, Gibson CM, Antman EM (2007) Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 357(20):2001–2015. https://doi.org/10.1056/nejmoa0706482

Article  PubMed  Google Scholar 

Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, Horrow J, Husted S, James S, Katus HA, Mahaffey KW, Scirica BM, Skene AM, Steg PG, Storey RF, Harrington RA (2009) Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361(11):1045–1057. https://doi.org/10.1056/nejmoa0904327

Article  PubMed  Google Scholar 

Généreux P, Giustino G, Witzenbichler B, Weisz G, Stuckey T, Rinaldi M, Neumann FJ, Metzger DC, Henry TD, Cox DA, Duffy PL, Mazzaferri EL, Yadav M, Francese DP, Palmerini T, Kirtane AJ, Litherland C, Mehran R, Stone GW (2015) Incidence, predictors, and impact of post-discharge bleeding after percutaneous coronary intervention. J Am Coll Cardiol 66(9):1036–1045. https://doi.org/10.1016/j.jacc.2015.06.1323

Article  PubMed  Google Scholar 

Palmerini T, Reggiani MLB, Della Riva D, Romanello M, Feres F, Abizaid A, Gilard M, Morice MC, Valgimigli M, Hong MK, Kim BK, Jang Y, Kim HS, Park KW, Colombo A, Chieffo A, Ahn JM, Park SJ, Schüpke S, Stone GW (2017) Bleeding-related deaths in relation to the duration of Dual-Antiplatelet therapy after coronary stenting. J Am Coll Cardiol 69(16):2011–2022. https://doi.org/10.1016/j.jacc.2017.02.029

Article  PubMed  Google Scholar 

Alexopoulos D, Mpahara A, Kassimis G (2019) Omitting aspirin in PCI patients: myth or reality? Cardiovasc Drugs Ther 33(6):711–724. https://doi.org/10.1007/s10557-019-06916-7

Article  PubMed  Google Scholar 

Jeżewski MP, Kubisa MJ, Eyileten C, De Rosa S, Christ G, Lesiak M, Indolfi C, Toma A, Siller-Matula JM, Postuła M (2019) Bioresorbable vascular scaffolds—dead end or still a rough diamond? J Clin Med 8(12):2167. https://doi.org/10.3390/jcm8122167

Article  PubMed  PubMed Central  Google Scholar 

Urban P, Meredith IT, Abizaid A, Pocock SJ, Carrié D, Naber C, Lipiecki J, Richardt G, Íñiguez A, Brunel P, Valdés-Chávarri M, Garot P, Talwar S, Berland J, Abdellaoui M, Eberli FR, Oldroyd KG, Zambahari R, Gregson J, Morice M (2015) Polymer-free drug-coated coronary stents in patients at high bleeding risk. N Engl J Med 373(21):2038–2047. https://doi.org/10.1056/nejmoa1503943

Article  PubMed  Google Scholar 

Varenne O, Cook S, Sidéris G, Kedev S, Cuisset T, Carrié D, Hovasse T, Garot P, Mahmoud RE, Spaulding C, Helft G, Fernández JFD, Brugaletta S, Pinar-Bermúdez E, Ferré JM, Commeau P, Teiger E, Bogaerts K, Sabaté M, Sinnaeve P (2018) Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial. The Lancet 391(10115):41–50. https://doi.org/10.1016/s0140-6736(17)32713-7

Article  Google Scholar 

Feng W, Hsieh I, Li Y (2021) P2Y12 inhibitor monotherapy after percutaneous coronary intervention: is it safe to abandon aspirin? Acta Cardiologica Sinica 37(1):1–8. https://doi.org/10.6515/acs.202101_37(1).20200806a

Article  PubMed  PubMed Central  Google Scholar 

Serebruany VL, Steinhubl SR, Berger PB, Malinin AI, Bhatt DL, Topol EJ (2005) Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol 45(2):246–251. https://doi.org/10.1016/j.jacc.2004.09.067

Article  PubMed  Google Scholar 

Roden DM, Shuldiner AR (2010) Responding to the clopidogrel warning by the US food and drug administration: real life is complicated. Circulation. https://doi.org/10.1161/circulationaha.110.973362

Article  PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Rev Esp Cardiol 74(9):790–799. https://doi.org/10.1016/j.rec.2021.07.01

Article  PubMed  Google Scholar 

Hong SJ, Lee S, Suh Y, Yun KH, Kang T, Shin S, Kwon SW, Lee J, Cho D, Park JK, Bae J, Kang WC, Kim SE, Lee Y, Ahn C, Kim JS, Kim BK, Ko YG, Choi D, Hong MK (2023) Stopping aspirin within 1 month after stenting for ticagrelor monotherapy in acute coronary syndrome: the T-PASS randomized noninferiority trial. Circulation. https://doi.org/10.1161/circulationaha.123.066943

Article  PubMed  PubMed Central  Google Scholar 

Baber U, Dangas G, Angiolillo DJ, Cohen DJ, Sharma SK, Nicolas J, Briguori C, Yu J, Collier T, Dudek D, Džavík V, Escaned J, Gil R, Gurbel PA, Hamm CW, Henry TD, Huber K, Kastrati A, Kaul U, Mehran R (2020) Ticagrelor alone vs. ticagrelor plus aspirin following percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes: TWILIGHT-ACS. Eur Heart J 41(37):3533–3545

Article  PubMed  Google Scholar 

Ge Z, Kan J, Gao X, Raza A, Zhang J-J, Mohydin BS, Gao F, Shao Y, Wang Y, Zeng H, Li F, Khan HS, Mengal N, Cong H, Wang M, Chen L, Wei Y, Chen F, Stone GW, Chen SL, ULTIMATE-DAPT investigators (2024) Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial. Lancet (London, England) 403(10439):1866–1878. https://doi.org/10.1016/S0140-6736(24)00473-2

Article  PubMed  Google Scholar 

Min P-K, Kang TS, Cho Y-H, Cheong S-S, Kim B-K, Kwon SW, Park WJ, Lee J-H, Kim W, Lee W-S, Yoon YW, Lee BK, Kwon HM, Hong B-K (2024) P2Y12 inhibitor monotherapy vs dual antiplatelet therapy after deployment of a drug-eluting stent. JAMA Netw Open 7(3):e240877. https://doi.org/10.1001/jamanetworkopen.2024.0877

Article  PubMed  PubMed Central  Google Scholar 

Kim BK, Hong S, Cho Y, Yun KH, Kim YH, Suh Y, Cho J, Her A, Cho S, Jeon DW, Yoo S, Cho D, Hong B, Kwon HM, Ahn C, Shin DH, Nam CM, Kim J, Ko YG, Investigators T (2020) Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular events in patients with acute coronary syndrome. JAMA 323(23):2407. https://doi.org/10.1001/jama.2020.7580

Article  PubMed  PubMed Central  Google Scholar 

Tomaniak M, Chichareon P, Onuma Y, Deliargyris EN, Takahashi K, Kogame N, Modolo R, Chang CC, Rademaker-Havinga T, Storey RF, Dangas G, Bhatt DL, Angiolillo DJ, Hamm CW, Valgimigli M, Windecker S, Steg PG, Vranckx P, Serruys PW (2019) Benefit and risks of aspirin in addition to ticagrelor in acute coronary syndromes. JAMA Cardiology 4(11):1092. https://doi.org/10.1001/jamacardio.2019.3355

Article  PubMed  PubMed Central  Google Scholar 

Feng W-H, Chang Y-C, Lin Y-H, Chen H-L, Chen C-Y, Lin T-H, Lin T-C, Chang C-T, Kuo H-F, Chang H-M, Chu C-S (2023) P2Y12 Inhibitor monotherapy versus conventional dual antiplatelet therapy in patients with acute coronary syndrome after percutaneous coronary intervention: a meta-analysis. Pharmaceuticals 16(2):232. https://doi.org/10.3390/ph16020232

Article  PubMed  PubMed Central  Google Scholar 

Gelbenegger G, Schoergenhofer C, Jilma B, Gager GM, Dizdarevic AM, Mamas MA, Parapid B, Velagapudi P, Siller-Matula JM (2021) Efficacy and safety of ticagrelor monotherapy in patients undergoing percutaneous coronary intervention: a meta-analysis. Clin Pharmacol Ther 110(2):424–431. https://doi.org/10.1002/cpt.2226

Article  PubMed  PubMed Central  Google Scholar 

Valgimigli M, Gragnano F, Branca M, Franzone A, Da Costa BR, Baber U, Kimura T, Jang Y, Hahn J-Y, Zhao Q, Windecker S, Gibson CM, Watanabe H, Kim B-K, Song YB, Zhu Y, Vranckx P, Mehta S, Ando K, Hong SJ, Gwon H-C, Serruys PW, Dangas GD, McFadden EP, Angiolillo DJ, Heg D, Calabrò P, Jüni P, Mehran R, Single Versus Dual Antiplatelet Therapy (Sidney-3) Collaboration (2024) Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis. JAMA Cardiol 9(5):437–448. https://doi.org/10.1001/jamacardio.2024.0133

Article  PubMed  Google Scholar 

Condello F, Sturla M, Terzi R, Polimeni A, Stefanini GG (2021) Walking the line with ticagrelor: meta-analysis comparing the safety and efficacy of ticagrelor monotherapy after a short course of ticagrelor-based dual antiplatelet therapy versus standard therapy in complex percutaneous coronary intervention. J Clin Med 10(23):5506. https://doi.org/10.3390/jcm10235506

Article  PubMed  PubMed Central 

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