Carr ZJ et al (2023) Perioperative Pulmonary complications in the Elderly: the Forgotten System. Anesthesiol Clin 41(3):531–548. https://doi.org/10.1016/j.anclin.2023.02.005

Article  PubMed  Google Scholar 

Bai R et al (2023) Projections of future life expectancy in China up to 2035: a modelling study. Lancet Public Health 8(12):e915–e922. https://doi.org/10.1016/s2468-2667(22)00338-3

Article  PubMed  Google Scholar 

H OB, et al. (2017) Mind over Matter? The hidden epidemic of cognitive dysfunction in the older Surgical patient. Ann Surg 265 (4): 677–691

Ho IS et al (2022) Variation in the estimated prevalence of multimorbidity: systematic review and meta-analysis of 193 international studies. BMJ Open 12(4):e057017. https://doi.org/10.1136/bmjopen-2021-057017

Article  PubMed  PubMed Central  Google Scholar 

Kim DK (2020) Nonoperating room anaesthesia for elderly patients. Curr Opin Anaesthesiol 33(4):589–593. https://doi.org/10.1097/aco.0000000000000883

Article  PubMed  Google Scholar 

Derwall M, Coburn M (2021) Safety and quality of perioperative anesthesia care-ensuring safe care for older people living with frailty. Best Pract Res Clin Anaesthesiol 35(1):3–9. https://doi.org/10.1016/j.bpa.2020.04.007

Article  PubMed  Google Scholar 

Wu H et al (2021) Study protocol for a randomised controlled clinical trial comparing desflurane-based versus propofol-based anaesthesia on postanaesthesia respiratory depression in patients with obstructive sleep apnoea after major abdominal surgery. BMJ Open 11(10):e051892. https://doi.org/10.1136/bmjopen-2021-051892

Article  PubMed  PubMed Central  Google Scholar 

Sneyd JR et al (2022) Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis. Br J Anaesth 128(4):610–622. https://doi.org/10.1016/j.bja.2021.10.044

Article  CAS  PubMed  Google Scholar 

Jalota L et al (2011) Prevention of pain on injection of propofol: systematic review and meta-analysis. BMJ 342:d1110. https://doi.org/10.1136/bmj.d1110

Article  CAS  PubMed  Google Scholar 

Zhong Y et al (2023) Evaluating efficacy and safety of sub-anesthetic dose esketamine as an adjuvant to propofol/remifentanil analgosedation and spontaneous respiration for children flexible fibreoptic bronchoscopy: a prospective, double-blinded, randomized, and placebo-controlled clinical trial. Front Pharmacol 14:1184663. https://doi.org/10.3389/fphar.2023.1184663

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao J et al (2022) Pharmacodynamics and Pharmacokinetics of HSK3486, a novel 2,6-Disubstituted Phenol Derivative as a General Anesthetic. Front Pharmacol 13:830791. https://doi.org/10.3389/fphar.2022.830791

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei Y et al (2017) Oral delivery of Propofol with Methoxymethylphosphonic Acid as the delivery vehicle. J Med Chem 60(20):8580–8590. https://doi.org/10.1021/acs.jmedchem.7b01133

Article  CAS  PubMed  Google Scholar 

Tao J et al (2023) Pharmacokinetics, pharmacodynamics, and safety of ciprofol emulsion in Chinese subjects with normal or impaired renal function. Front Pharmacol 14:1260599. https://doi.org/10.3389/fphar.2023.1260599

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen BZ et al (2022) The efficacy and safety of ciprofol use for the induction of general anesthesia in patients undergoing gynecological surgery: a prospective randomized controlled study. BMC Anesthesiol 22(1):245. https://doi.org/10.1186/s12871-022-01782-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J et al (2022) Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: a multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial. Basic Clin Pharmacol Toxicol 131(2):138–148. https://doi.org/10.1111/bcpt.13761

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yi QL et al (2022) Comparison of ciprofol and propofol in elderly patients undergoing painless gastroscopy. J Clin Anesthesiol 38:712–715

Google Scholar 

Xu MWY, Song DD (2023) Comparison of sedative effect of ciprofol and propofol in elder patients undergoing fibrocolonoscopy treatment. J Clin Anesthesiol 39:705–708

Google Scholar 

Jun Chen et al (2023) Efficacy and safety of ciprofol in the induction of general anesthesia in elderly patients undergoing urological surgery. Chin J Clin Ration Drug Use 16(24):103–106. https://doi.org/10.15887/j.cnki.13-1389/r.2023.24.030

Article  Google Scholar 

Chao Wang et al (2023) Effectiveness of ciprofol combined with alfentanil for colonoscopy in elderly patients with asthenia. J Clin Anesthesiology 39:550–552. https://doi.org/10.12089/jca.2023.05.021

Article  Google Scholar 

Wenting Sun et al (2023) Effect of ciprofol and propofol on postoperative cognitive function in elderly patients undergoing laparoscopic cholecystectomy. Chin J Drug Application Monit 20:295–298. https://doi.org/10.3969/j.issn.1672-8157.2023.05.002

Article  Google Scholar 

Xiang Zhang, Zhu T (2023) The effect of cyclosporine on respiratory function during painless gastroscopy in elderly patients. J Clin Anesthesiology 39(3):330–332. https://doi.org/10.12089/jca.2023.03.023

Article  Google Scholar 

Wantong Zhao et al (2023) Efficacy of ciprofol in elderly patients undergoing endoscopic retrograde cholangiopancreatography. J Clin Anesthesiology 39(6):610–613. https://doi.org/10.12089/jca.2023.06.010

Article  Google Scholar 

Yingji Shen et al (2024) Study on the safety of ciprofol combined with alfentanil for ERCP anesthesia in eld-erly patients. Practical Pharm Clin Remedies 27(1):22–25. https://doi.org/10.14053/j.cnki.ppcr.202401005

Article  CAS  Google Scholar 

Gao Z et al (2023) Applicability of ciprofol combined with nalbuphine in painless gastroenteroscopy on elder-ly patients. Med J Chin People’s Armed Police Forces 34(4):330–334. https://doi.org/10.3969/j.issn.1004-3594.2023.04.012

Article  Google Scholar 

Dan Wang et al (2024) Effect of cyclophenol on hemodynamics and postoperative quality of recovery in elderly patients undergoing thoracoscopic radical resection for lung cancer. China J Mod Med 34(2):18–22. https://doi.org/10.3969/j.issn.1005-8982.2024.02.004

Article  Google Scholar 

Liu Z et al (2024) The Effect of Ciprofol on Postoperative Delirium in Elderly patients undergoing thoracoscopic surgery for Lung Cancer: a prospective, randomized, controlled trial. Drug Des Devel Ther 18:325–339. https://doi.org/10.2147/dddt.S441950

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sterne JAC et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https://doi.org/10.1136/bmj.l4898

Article  PubMed  Google Scholar 

Egger M et al (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634. https://doi.org/10.1136/bmj.315.7109.629

Article  CAS  PubMed  PubMed Central  Google Scholar 

Page MJ et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Med 18(3):e1003583. https://doi.org/10.1371/journal.pmed.1003583

Article  PubMed  PubMed Central  Google Scholar 

Yang D et al (2023) Drug-drug interaction study of ciprofol and sodium divalproex: pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects. Clin Transl Sci 16(10):1972–1981. https://doi.org/10.1111/cts.13605

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu M et al (2023) Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia? Biomed Res Int 2023: 7443226 https://doi.org/10.1155/2023/7443226

Qin L et al (2017) Design, synthesis, and evaluation of Novel 2,6-Disubstituted phenol derivatives as general anesthetics. J Med Chem 60(9):3606–3617. https://doi.org/10.1021/acs.jmedchem.7b00254

Article  CAS  PubMed  Google Scholar 

Park S et al (2020) Intraoperative Anesthetic Management of patients with chronic obstructive pulmonary disease to decrease the risk of postoperative pulmonary complications after abdominal surgery. J Clin Med 9(1).