Supported by the Taishan Scholars Program of Shandong Province, the National Natural Science Foundation of China (grants 81525021, 81672431, 81672435, 81720108028, 81772633, 81702426, 81702427, 81572618, 81802432, 81802433, 81871968 and 81871978). Key Program of Prevention and Treatment of Chronic Diseases of Tianjin (17ZXMFSY001), the programs of Tianjin Prominent Talents, Tianjin Eminent Scholars and Tianjin Natural Science Fund for Distinguished Young Scholar. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.