KM Rossow is supported by the National Institutes of Health's National Institute of General Medical Sciences Clinical Pharmacology Training Program 5T32 GM007569 and the Thrasher Research Fund. JR Strawn has received research support from the National Institutes of Health (NIMH/NIEHS/NICHD) as well as PCORI, Allergan and Otsuka. He has received material support from and provided consultation to Myriad Genetics. He also consulted to the Food and Drug Administration and Intracellular Therapeutics and receives royalties from the publication of two texts (Springer). He has provided CME presentations for Neuroscience Education Institute, CMEology, MedScape and Psych Congress and Genomind. LB Ramsey has received research funding from the National Institutes of Health (NICHD HD104223), and BTG International, and has served as a consultant for OncLive, Nuventra Pharma Sciences and BTG International. SL Van Driest has received research funding from the National Institutes of Health (NIGMS and NHGRI), the Doris Duke Foundation and the Burroughs Wellcome Fund. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.