McIntyre RS, Berk M, Brietzke E, Goldstein BI, López-Jaramillo C, Kessing LV, et al. Bipolar disorders. Lancet. 2020;396:1841–56.

Article  CAS  PubMed  Google Scholar 

Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet. 2013;382:1575–86.

Article  PubMed  Google Scholar 

Burdick KE, Russo M, Frangou S, Mahon K, Braga RJ, Shanahan M, et al. Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications. Psychol Med. 2014;44:3083–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Solé B, Bonnin CM, Jiménez E, Torrent C, Torres I, Varo C, et al. Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster-analytic approach. Acta Psychiatr Scand. 2018;137:516–27.

Article  PubMed  Google Scholar 

Bora E. Neurocognitive features in clinical subgroups of bipolar disorder: a meta-analysis. J Affect Disord. 2018;229:125–34.

Article  PubMed  Google Scholar 

Martino DJ, Marengo E, Igoa A, Strejilevich SA. Neurocognitive heterogeneity in older adults with bipolar disorders. Psychiatry Res. 2018;262:510–2.

Article  PubMed  Google Scholar 

Savitz JB, Rauch SL, Drevets WC. Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play. Mol Psychiatry. 2013;18:528–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abi-Dargham A, Horga G. The search for imaging biomarkers in psychiatric disorders. Nat Med. 2016;22:1248–55.

Article  CAS  PubMed  Google Scholar 

Zarp Petersen J, Varo C, Skovsen CF, Ott CV, Kjærstad HL, Vieta E, et al. Neuronal underpinnings of cognitive impairment in bipolar disorder: a large data-driven functional magnetic resonance imaging study. Bipolar Disord. 2022;24:69–81.

Article  PubMed  Google Scholar 

Alonso-Lana S, Goikolea JM, Bonnin CM, Sarró S, Segura B, Amann BL, et al. Structural and functional brain correlates of cognitive impairment in euthymic patients with bipolar disorder. PLoS One. 2016;11:1–17.

Article  Google Scholar 

Kollmann B, Yuen K, Scholz V, Wessa M. Cognitive variability in bipolar I disorder: a cluster-analytic approach informed by resting-state data. Neuropharmacology. 2019;156:107585.

Article  CAS  PubMed  Google Scholar 

Chakrabarty T, Torres IJ, Su WW, Sawatzky R, Keramatian K, Yatham LN. Cognitive subgroups in first episode bipolar I disorder: relation to clinical and brain volumetric variables. Acta Psychiatr Scand. 2021;143:151–61.

Article  PubMed  Google Scholar 

Njau S, Townsend J, Wade B, Hellemann G, Bookheimer S, Narr K, et al. Neural subtypes of euthymic bipolar I disorder characterized by emotion regulation circuitry. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5:591–600.

PubMed  Google Scholar 

Kjærstad HL, Damgaard V, Knudsen GM, Vinberg M, Vedel L, Macoveanu J, et al. Neural underpinnings of emotion regulation subgroups in remitted patients with recently diagnosed bipolar disorder. Eur Neuropsychopharmacol. 2022;60:7–18.

Article  PubMed  Google Scholar 

Zhuang X, Yang Z, Cordes D. A technical review of canonical correlation analysis for neuroscience applications. Hum Brain Mapp. 2020;41:3807–33.

Article  PubMed  PubMed Central  Google Scholar 

McIntosh AR, Mišić B. Multivariate statistical analyses for neuroimaging data. Annu Rev Psychol. 2013;64:499–525.

Article  PubMed  Google Scholar 

Wang HT, Smallwood J, Mourao-Miranda J, Xia CH, Satterthwaite TD, Bassett DS, et al. Finding the needle in a high-dimensional haystack: canonical correlation analysis for neuroscientists. Neuroimage. 2020;216:116745.

Article  PubMed  Google Scholar 

Little B, Flowers C, Blamire A, Thelwall P, Taylor JP, Gallagher P, et al. Multivariate brain-cognition associations in euthymic bipolar disorder. Bipolar Disord. 2024:26;604–16.

Moser DA, Doucet GE, Lee WH, Rasgon A, Krinsky H, Leibu E, et al. Multivariate associations among behavioral, clinical, and multimodal imaging phenotypes in patients with psychosis. JAMA Psychiatry. 2018;75:386–95.

Article  PubMed  PubMed Central  Google Scholar 

Kessing LV, Munkholm K, Faurholt-Jepsen M, Miskowiak KW, Nielsen LB, Frikke-Schmidt R, et al. The Bipolar illness onset study: research protocol for the BIO cohort study. BMJ Open. 2017;7:e015462.

Ott CV, Vinberg M, Kessing LV, Bowie CR, Forman JL, Miskowiak KW. Effect of Action-Based Cognitive Remediation on cognitive impairment in patients with remitted bipolar disorder: a randomized controlled trial. Bipolar Disord. 2021;23:487–99.

Article  PubMed  Google Scholar 

Macoveanu J, Petersen JZ, Mariegaard J, Jespersen AE, Cramer K, Bruun CF, et al. Effects of erythropoietin on cognitive impairment and prefrontal cortex activity across affective disorders: a randomized, double-blinded, placebo-controlled trial. J Psychopharmacol. 2024;38:362–74.

Article  CAS  PubMed  Google Scholar 

Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel R, et al. SCAN. Schedules for clinical assessment in neuropsychiatry. Arch Gen Psychiatry. 1990;47:589–93.

Article  CAS  PubMed  Google Scholar 

Hamilton M. A rating scale for depression. J Neurol, Neurosurg, Psychiatry. 1960;23:56–63.

Article  CAS  PubMed  Google Scholar 

Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133:429–35.

Article  CAS  PubMed  Google Scholar 

Rosa AR, Sánchez-Moreno J, Martínez-Aran A, Salamero M, Torrent C, Reinares M, et al. Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder. Clin Pract Epidemiol Ment Health. 2007;3:1–8.

Article  Google Scholar 

Mundt JC, Marks IM, Shear MK, Greist JH. The Work and Social Adjustment Scale: a simple measure of impairment in functioning. Br J Psychiatry. 2002;180:461–4.

Article  PubMed  Google Scholar 

Lezik MD. Memory I: tests. In: Lezik MD, editor. Neuropsychological assessment. 3rd ed. NY: Oxford University Press; 1995. p. 429-98.

Army Individual Test Battery. Manual of directions and scoring. Washington, DC: War Department, Adjunt General’s Office; 1944.

Randolph C, Tierney MC, Mohr E, Chase TN. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol. 1998;20:310–9.

Article  CAS  PubMed  Google Scholar 

Wechsler D. WAIS-III: administration and scoring manual: Wechsler Adult Intelligence Scale. San Antonio, Texas: Psychological Corporation; 1997.

Borkowski JG, Benton AL, Spreen O. Word fluency and brain damage. Neuropsychologia. 1967;5:135–40.

Article  Google Scholar 

Miskowiak KW, Petersen CS. Neuronal underpinnings of cognitive impairment and - Improvement in mood disorders. CNS Spectr. 2019;24:30–53.

Article  PubMed  Google Scholar 

Saldarini F, Gottlieb N, Stokes PRA. Neural correlates of working memory function in euthymic people with bipolar disorder compared to healthy controls: A systematic review and meta-analysis. J Affect Disord. 2022;297:610–22.

Article  PubMed  Google Scholar 

Woolrich MW, Beckmann TEJBCF, Jenkinson M, Smith SM. Multilevel linear modelling for FMRI group analysis using Bayesian inference. Neuroimage. 2004;21:1732–47.

Article  PubMed  Google Scholar 

Macoveanu J, Petersen JZ, Fisher PM, Kessing LV, Knudsen GM, Miskowiak KW. Associations between aberrant working memory-related neural activity and cognitive impairments in somatically healthy, remitted patients with mood disorders. Psychol Med. 2023;53:7203–13.

Waller L, Erk S, Pozzi E, Toenders YJ, Haswell CC, Büttner M, et al. ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data. Hum Brain Mapp. 2022;43:2727–42.

Article  PubMed  PubMed Central  Google Scholar 

Esteban O, Markiewicz CJ, Blair RW, Moodie CA, Isik AI, Erramuzpe A, et al. fMRIPrep: a robust preprocessing pipeline for functional MRI. Nat Methods. 2019;16:111–6.

Article  CAS  PubMed  Google Scholar 

Behzadi Y, Restom K, Liau J, Liu T. A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Neuroimage. 2007;37:90–101.

Article