Abdel-Salam OM, Hamdy SM, Seadawy SAM, Galal AF, Abouelfadl DM, Atrees SS (2016) Effect of piracetam, vincamine, vinpocetine, and donepezil on oxidative stress and neurodegeneration induced by aluminum chloride in rats. Comp Clin Pathol. 25:305–18

Article  CAS  Google Scholar 

Abd-Rabou AA, Ahmed HH, Kishta MS et al (2022a) Selective viramidine-loaded aptamer-nanoparticles trigger cell cycle arrest in nucleolin-expressed hepatoma cells through modulation of CDC25A/p53/PI3k pathway. J Clust Sci. 34:335–345

Article  Google Scholar 

Abd-Rabou AA, Ahmed HH, Kishta MS (2022b) Implication of extrinsic and intrinsic apoptotic pathways in the targeted therapy of hepatocellular carcinoma using aptamer-labeled viramidine nanoparticles. BMC Cancer 22(1):1106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abd-Rabou AA, Ahmed HH, Mohamed SH (2022c) Nanotherapy: new approach for impeding hepatic cancer microenvironment via targeting multiple molecular pathways. Asian Pac J Cancer Prev 23(12):4261

Abd-Rabou AA, Kishta MS, Yakout SM et al (2024) Copper/Tin nanocomposites‐loaded exosomes induce apoptosis and cell cycle arrest at G0/G1 phase in skin cancer cell line. Chem Biodivers 21(8):e202400486

Aglan HA, Ahmed HH, Beherei HH et al (2024) Generation of cardiomyocytes from stem cells cultured on nanofibrous scaffold: experimental approach for attenuation of myocardial infarction. Tissue Cell 89:102461

Article  CAS  PubMed  Google Scholar 

Agwupuye AJ, Gber TE, Edet HO et al (2023) Molecular modeling, DFT studies and biological evaluation of methyl 2,8-dichloro-1,2-dihydroquinoline-3-carboxylate. Chem Phys Impact 6:100146

Bach-Rojecky L, Lacković Z (2005) Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain. Croat Med J. 46(2):201–8

PubMed  Google Scholar 

Bach-Rojecky L, Lacković Z (2005) Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain. Croatian medical journal. 46(2):201–8

PubMed  Google Scholar 

Beura SK, Dhapola R, Panigrahi AR, Yadav P, Kumar R, Reddy DH et al (2023) Antiplatelet drugs: potential therapeutic options for the management of neurodegenerative diseases. Med Res Rev. 43(6):1835–77

Article  CAS  PubMed  Google Scholar 

Bilici D, Akpinar E, Kiziltunc A (2002) Protective effect of melatonin in carrageenan-induced acute local inflammation. Pharmacol Res. 46(2):133–9

Article  CAS  PubMed  Google Scholar 

Bindu S, Mazumder S, Bandyopadhyay U (2020) Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem Pharmacol. 180:114147

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borozdenko DA, Shmigol TA, Ezdoglian AA, Gonchar DI, Karpechenko NY, Lyakhmun DN et al (2022) The effect of a new N-hetero cycle derivative on behavior and inflammation against the background of ischemic stroke. Molecules. 27(17):5488

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buritova J, Honoré P, Besson J-M (1995) Indomethacin reduces both Krox-24 expression in the rat lumbar spinal cord and inflammatory signs following intraplantar carrageenan. Brain Res. 674(2):211–20

Article  CAS  PubMed  Google Scholar 

Caruso R, Rocchiccioli S, Gori AM, Cecchettini A, Giusti B, Parodi G et al (2015) Inflammatory and antioxidant pattern unbalance in “clopidogrel-resistant” patients during acute coronary syndrome. Mediat Inflamm. 2015(1):710123

Article  Google Scholar 

Cheong M-H, Lee S-R, Yoo H-S et al (2011) Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-κB activation in lipopolysaccharide-induced BV2 microglial cells. J Ethnopharmacol. 137(3):1402–1408

Article  PubMed  Google Scholar 

Dong H, Zhang X, Dai X et al (2014) Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway. J Neuroinflammation. 11:140

Article  PubMed  PubMed Central  Google Scholar 

Elimadi A, Bouillot L, Sapena R, Tillement J-P, Morin D (1998) Dose-related inversion of cinnarizine and flunarizine effects on mitochondrial permeability transition. Eur J Pharmacol. 348(1):115–21

Article  CAS  PubMed  Google Scholar 

Faes S, Dormond O (2015) PI3K and AKT: unfaithful partners in cancer. Int J Mol Sci. 16(9):21138–52

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fagone P, Caltabiano R, Russo A, Lupo G, Anfuso CD, Basile MS et al (2017) Identification of novel chemotherapeutic strategies for metastatic uveal melanoma. Sci Rep. 7(1):44564

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frisch M, Trucks G, Schlegel H et al (2016) Gaussian, Inc. Wallingford, CT

Glaviano A, Foo AS, Lam HY, Yap KC, Jacot W, Jones RH et al (2023) PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Mol Cancer. 22(1):138

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gouhie FA, Barbosa KO, Amanda Borges Rufino Cruz AB (2024) Cognitive effects of piracetam in adults with memory impairment: a systematic review and meta-analysis. Clin Neurol Neurosurge 243:108358

Gross ME, Agus DB, Dorff TB, Pinski JK, Quinn DI, Castellanos O et al (2021) Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer. Prostate Cancer Prost Dis. 24(1):61–8

Article  CAS  Google Scholar 

Haddadi R, Rashtiani R (2020) Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress. Inflammopharmacology. 28:903–13

Article  CAS  PubMed  Google Scholar 

Hammody LE, Matloub SY, Shihab SS (2015) Pregabalin versus amitriptyline in the treatment of fibromyalgia patients (a double blind comparative study). Iraqi Postgrad Med J. 14(1):39–45

Google Scholar 

Heitzer T, Rudolph V, Schwedhelm E, Karstens M, Sydow K, Ortak M et al (2006) Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effects. Arterioscleros Thromb Vasc Biol. 26(7):1648–52

Article  CAS  Google Scholar 

Hickey AL, Rowley CN (2014) Benchmarking quantum chemical methods for the calculation of molecular dipole moments and polarizabilities. J Phys Chem A 118(20):3678–3687

Article  CAS  PubMed  Google Scholar 

Horvath B, Marton Z, Halmosi R, Alexy T, Szapary L, Vekasi J et al (2002) In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine. Clin Neuropharmacol. 25(1):37–42

Article  CAS  PubMed  Google Scholar 

Hosseini A, Abdollahi M (2013) Diabetic neuropathy and oxidative stress: therapeutic perspectives. Oxid Med Cell Long. 1:168039

Google Scholar 

Hwang H-J, Lee H-J, Kim C-J, Shim I-S, Hahm D-H (2008) Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-$\alpha $ and IL-l $\beta $ mRNA expression and carrageenan-induced rat arthritis. J Microbiol Biotechnol. 18(10):1641–7

CAS  PubMed  Google Scholar 

Hwang S-J, Park KW, Kwon D-A, Kang H-J, Koo B-K, Chae I-H et al (2011) High plasma interleukin-6 is associated with drug-eluting stent thrombosis–possible role of inflammatory cytokines in the development of stent thrombosis from the Korea Stent Thrombosis Registry–. Circ J. 75(6):1350–7

Article  CAS  PubMed  Google Scholar 

Iwano T, Toda H, Nakamura K, Shimizu K, Ejiri K, Naito Y et al (2021) Preventative effects of bisoprolol transdermal patches on postoperative atrial fibrillation in high-risk patients undergoing non-cardiac surgery: a subanalysis of the MAMACARI study. J Cardiol. 78(5):349–54

Article  PubMed  Google Scholar 

Ju Z, Li M, Xu J, Howell DC, Li Z, Chen FE (2022) Recent development on COX-2 inhibitors as promising anti-inflammatory agents: the past 10 years. Acta Pharm Sin B. 12(6):2790–2807

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keil U, Scherping I, Hauptmann S, Schuessel K, Eckert A, Müller WE (2006) Piracetam improves mitochondrial dysfunction following oxidative stress. Br J Pharmacol. 147(2):199–208

Article  CAS  PubMed  Google Scholar 

Kenouche S, Sandoval-Yañez C, Martínez-Araya JI (2022) The antioxidant capacity of myricetin A molecular electrostatic potential analysis based on DFT calculations. Chem Phys Lett 801:139708

Article  CAS  Google Scholar 

Khattab MM (2006) TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite-and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. Eur J Pharmacol. 548(1–3):167–73

Article  CAS  PubMed