US Food and Drug Administration (FDA) (2017) HERCEPTIN® (trastuzumab) US Prescribing Information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103792s5337lbl.pdf. Accessed 7 Apr 2023
Boekhout AH, Beijnen JH, Schellens JH (2011) Trastuzumab Oncologist 16(6):800–810
Article CAS PubMed Google Scholar
Diaby V, Tawk R, Sanogo V, Xiao H, Montero AJ (2015) A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer. Breast Cancer Res Treat 151(1):27–40
Article CAS PubMed PubMed Central Google Scholar
Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL (2002) Herceptin-induced inhibition of phosphatidylinositol-3 kinase and akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 62(14):4132–4141
Lane HA, Beuvink I, Motoyama AB, Daly JM, Neve RM, Hynes NE (2000) ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency. Mol Cell Biol 20(9):3210–3223
Article CAS PubMed PubMed Central Google Scholar
Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J (2001) Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res 61(12):4744–4749
Kute T, Stehle JR Jr., Ornelles D, Walker N, Delbono O, Vaughn JP (2012) Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology 1(6):810–821
Article PubMed PubMed Central Google Scholar
Klos KS, Zhou X, Lee S et al (2003) Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of akt than either treatment alone. Cancer 98(7):1377–1385
Article CAS PubMed Google Scholar
Tsao LC, Crosby EJ, Trotter TN et al (2019) CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. JCI Insight. ;4(24)
Quartino AL, Hillenbach C, Li J et al (2016) Population pharmacokinetic and exposure-response analysis for trastuzumab administered using a subcutaneous manual syringe injection or intravenously in women with HER2-positive early breast cancer. Cancer Chemother Pharmacol 77(1):77–88
Article CAS PubMed Google Scholar
Yang J, Zhao H, Garnett C et al (2013) The combination of exposure-response and case-control analyses in regulatory decision making. J Clin Pharmacol 53(2):160–166
Bruno R, Washington CB, Lu JF, Lieberman G, Banken L, Klein P (2005) Population pharmacokinetics of trastuzumab in patients with HER2 + metastatic breast cancer. Cancer Chemother Pharmacol 56(4):361–369
Article CAS PubMed Google Scholar
Levêque D, Gigou L, Bergerat JP (2008) Clinical pharmacology of trastuzumab. Curr Clin Pharmacol 3(1):51–55
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235(4785):177–182
Article CAS PubMed Google Scholar
Nahta R, Esteva FJ (2006) Herceptin: mechanisms of action and resistance. Cancer Lett 232(2):123–138
Article CAS PubMed Google Scholar
Schaller G, Evers K, Papadopoulos S, Ebert A, Bühler H (2001) Current use of HER2 tests.Ann Oncol. 12(Suppl 1):S97–S100
Roche (2023) Apr : Herceptin Product Information: AnnexI.Summary of product characteristics.https://www.ema.europa.eu/en/documents/product-information/herceptin-epar-product-information_en.pdf. Accessed 10
Maadi H, Soheilifar MH, Choi W-S, Moshtaghian A, Wang Z (2021) Trastuzumab Mechanism of Action; 20 years of Research to Unravel a Dilemma. Cancers 13:14
Dubska L, Andera L, Sheard MA (2005) HER2 signaling downregulation by trastuzumaband suppression of the PI3K/Akt pathway: an unexpected effect on TRAIL-induced apoptosis. FEBS Lett 579(19):4149–4158
Article CAS PubMed Google Scholar
Junttila TT, Akita RW, Parsons K et al (2009) Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 15(5):429–440
Article CAS PubMed Google Scholar
Baselga J, Carbonell X, Castaneda-Soto NJ et al (2005) Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 23(10):2162–2171
Article CAS PubMed Google Scholar
Leyland-Jones B, Gelmon K, Ayoub JP et al (2003) Pharmacokinetics, safety, and efficacy of trastuzumab administered every three weeks in combination with paclitaxel. J Clin Oncol 21(21):3965–3971
Article CAS PubMed Google Scholar
Maximiano S, Magalhaes P, Guerreiro MP, Morgado M (2016) Trastuzumab in the treatment of breast Cancer. BioDrugs 30(2):75–86
Article CAS PubMed Google Scholar
Terrell-Hall TB, Nounou MI, El-Amrawy F, Griffith JIG, Lockman PR (2017) Trastuzumab distribution in an in-vivo and in-vitro model of brain metastases of breast cancer. Oncotarget 8(48):83734–83744
Article PubMed PubMed Central Google Scholar
Murthy R, Borges VF, Conlin A et al (2018) Tucatinib with capecitabine and trastuzumab in advanced HER2-positive metastatic breast cancer with and without brain metastases: a non-randomised, open-label, phase 1b study. Lancet Oncol 19(7):880–888
Article CAS PubMed Google Scholar
Mutlu H, Buyukcelik A (2015) The combination of weekly trastuzumab plus vinorelbine may be preferable regimen in HER-2 positive breast cancer patients with brain metastasis. J Oncol Pharm Pract 21(4):310–312
Article CAS PubMed Google Scholar
Lin NU, Pegram M, Sahebjam S et al (2021) Pertuzumab Plus High-Dose Trastuzumab in patients with Progressive Brain metastases and HER2-Positive metastatic breast Cancer: primary analysis of a phase II study. J Clin Oncol 39(24):2667–2675
Article CAS PubMed PubMed Central Google Scholar
Pestalozzi BC, Brignoli S (2000) Trastuzumab in CSF. J Clin Oncol 18(11):2349–2351
Article CAS PubMed Google Scholar
Stemmler HJ, Schmitt M, Willems A, Bernhard H, Harbeck N, Heinemann V (2007) Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anticancer Drugs 18(1):23–28
Article CAS PubMed Google Scholar
Lai R, Dang CT, Malkin MG, Abrey LE (2004) The risk of central nervous system metastases after trastuzumab therapy in patients with breast carcinoma. Cancer 101(4):810–816
Article CAS PubMed Google Scholar
Lencer WI, Blumberg RS (2005) A passionate kiss, then run: exocytosis and recycling of IgG by FcRn. Trends Cell Biol 15(1):5–9
Article CAS PubMed Google Scholar
Tabrizi MA, Tseng CM, Roskos LK (2006) Elimination mechanisms of therapeutic monoclonal antibodies. Drug Discovery Today 11(1–2):81–88
Article CAS PubMed Google Scholar
Keizer RJ, Huitema AD, Schellens JH, Beijnen JH (2010) Clinical pharmacokinetics of therapeutic monoclonal antibodies. Clin Pharmacokinet 49(8):493–507
Article CAS PubMed Google Scholar
Quartino AL, Li H, Kirschbrown WP et al (2019) Population pharmacokinetic and covariate analyses of intravenous trastuzumab (Herceptin®), a HER2-targeted monoclonal antibody, in patients with a variety of solid tumors. Cancer Chemother Pharmacol 83(2):329–340
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