Biostatistics Unit, The Cyprus Institute of Neurology and Genetics, 6 Iroon Avenue, 2371 Ayios Dometios, Nicosia, Cyprus

Kristia Yiangou, Maria Zanti & Kyriaki Michailidou

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK

Nasim Mavaddat, Joe Dennis, Qin Wang, Manjeet K. Bolla, Michael Lush, Antonis C. Antoniou, Douglas F. Easton & Kyriaki Michailidou

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Mustapha Abubakar, Thomas U. Ahearn & Stella Koutros

Fred A, Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada

Irene L. Andrulis

Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

Irene L. Andrulis

Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA

Hoda Anton-Culver

NN Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus

Natalia N. Antonenkova & Natalia V. Bogdanova

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

Volker Arndt & Hermann Brenner

Department of Public Health Sciences, and Cancer Research Institute, Queen’s University, Kingston, ON, Canada

Kristan J. Aronson

Oncology, Clinical Sciences in Lund, Lund University, Lund, Sweden

Annelie Augustinsson & Helena Jernström

Department of Oncology, Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium

Adinda Baten

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Sabine Behrens, Jenny Chang-Claude & Rudolf Kaaks

Institute of Biochemistry and Genetics of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia

Marina Bermisheva & Elza K. Khusnutdinova

Petersburg State University, St. Petersburg, Russia

Marina Bermisheva

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK

Amy Berrington de Gonzalez

Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

Katarzyna Białkowska & Anna Jakubowska

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA

Nicholas Boddicker & Christopher G. Scott

Department of Population Science, American Cancer Society, Atlanta, GA, USA

Clara Bodelon, James Hodge, Alpa V. Patel & Lauren R. Teras

Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

Natalia V. Bogdanova

Gynaecology Research Unit, Hannover Medical School, Hannover, Germany

Natalia V. Bogdanova, Thilo Dörk & Tjoung-Won Park-Simon

Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

Stig E. Bojesen

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

Stig E. Bojesen

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Stig E. Bojesen

Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA

Kristen D. Brantley, A. Heather Eliassen & Walter Willett

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany

Hiltrud Brauch & Reiner Hoppe

iFIT-Cluster of Excellence, University of Tübingen, Tübingen, Germany

Hiltrud Brauch

German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Partner Site Tübingen, Tübingen, Germany

Hiltrud Brauch

German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

Hermann Brenner

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA

Nicola J. Camp & Sarah V. Colonna

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

Federico Canzian

Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur-Vigo-Spain, Vigo, Spain

Jose E. Castelao

Department of Pathology, Intermountain Healthcare, Salt Lake City, UT, USA

Melissa H. Cessna

Intermountain Biorepository, Intermountain Healthcare, Salt Lake City, UT, USA

Melissa H. Cessna

Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Jenny Chang-Claude

Cancer Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

Georgia Chenevix-Trench

Department of Pediatrics, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA

Wendy K. Chung

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

Vessela N. Kristensen

Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway

Vessela N. Kristensen

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

Fergus J. Couch

Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK

Angela Cox

Division of Neuroscience, School of Medicine and Population Health, University of Sheffield, Sheffield, UK

Simon S. Cross

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Kamila Czene, Mikael Eriksson, Juan Rodriguez & Per Hall

Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA

Mary B. Daly

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

Peter Devilee

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

Peter Devilee

Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK

Alison M. Dunning & Douglas F. Easton

Faculty of Medicine, University of Southampton, Southampton, UK

Diana M. Eccles

Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

A. Heather Eliassen, Cheng Peng & Walter Willett

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA

A. Heather Eliassen & Walter Willett

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

Christoph Engel

LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany

Christoph Engel

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

D. Gareth Evans

North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

D. Gareth Evans

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany

Peter A. Fasching

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK

Olivia Fletcher & Nichola Johnson

Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

Henrik Flyger

School of Population Health, Curtin University, Perth, WA, Australia

Lin Fritschi

Cancer Genetics and Epidemiology Group, Genomic Medicine Group, Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain

Manuela Gago-Dominguez

MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK

Aleksandra Gentry-Maharaj & Usha Menon

Department of Women’s Cancer, Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, UK

Aleksandra Gentry-Maharaj

Human Genotyping Unit-CeGen, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Anna González-Neira & Guillermo Pita

Spanish Network on Rare Diseases (CIBERER), Madrid, Spain

Anna González-Neira

Team ‘Exposome and Heredity’, CESP, Gustave Roussy, INSERM, University Paris-Saclay, UVSQ, Villejuif, France

Pascal Guénel

Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

Eric Hahnen & Rita K. Schmutzler

Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

Eric Hahnen & Rita K. Schmutzler

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Christopher A. Haiman

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

Ute Hamann & Muhammad U. Rashid

Cancer RC, University of Eastern Finland, Kuopio, Finland

Jaana M. Hartikainen

Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland

Jaana M. Hartikainen & Arto Mannermaa

Health Innovation and Evaluation Hub, Université de Montréal Hospital Research Centre (CRCHUM), Montréal, QC, Canada

Vikki Ho

Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 GD, Rotterdam, The Netherlands

Antoinette Hollestelle & Maartje J. Hooning

Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany

Ellen Honisch

University of Tübingen, Tübingen, Germany

Reiner Hoppe

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia

John L. Hopper, Jennifer Stone, Robert J. MacInnis & Roger L. Milne

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

Sacha Howell & Eleanor Roberts

Nightingale/Prevent Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK

Sacha Howell

Manchester Breast Centre, Manchester Cancer Research Centre, The Christie Hospital, Manchester, UK

Sacha Howell

Division of Cancer Sciences, University of Manchester, Manchester, UK

Anthony Howell

Research Centre for Genetic Engineering and Biotechnology ‘Georgi D. Efremov’, MASA, Skopje, Republic of North Macedonia

Simona Jakovchevska & Dijana Plaseska-Karanfilska

Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland

Anna Jakubowska

Department of Genetics and Fundamental Medicine, Ufa University of Science and Technology, Ufa, Russia

Elza K. Khusnutdinova

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA

Cari M. Kitahara

Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA

James V. Lacey

City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA

James V. Lacey

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium

Diether Lambrechts

VIB Center for Cancer Biology, VIB, Leuven, Belgium

Diether Lambrechts

Carmel Medical Center, Haifa, Israel

Flavio Lejbkowicz

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Annika Lindblom

Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden

Annika Lindblom

Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland

Arto Mannermaa

Biobank of Eastern Finland, Kuopio University Hospital, Kuopio, Finland

Arto Mannermaa

Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece

Dimitrios Mavroudis

School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada

Rachel A. Murphy

Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada

Rachel A. Murphy

Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

Heli Nevanlinna

Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Nadia Obi

Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Nadia Obi

Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Kenneth Offit

Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Kenneth Offit

Genome Diagnostics Program, IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy

Paolo Peterlongo

Laboratory of Cancer Genetics and Tumor Biology, Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland

Katri Pylkäs & Robert Winqvist

Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland

Katri Pylkäs & Robert Winqvist

Unit of Predictive Medicine, Molecular Bases of Genetic Risk, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori (INT), Milan, Italy

Paolo Radice

Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan

Muhammad U. Rashid

Technion, Faculty of Medicine and Association for Promotion of Research in Precision Medicine, Haifa, Israel

Gad Rennert

Medical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain

Atocha Romero

Department of Pathology, The Netherlands Cancer Institute - Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Efraim H. Rosenberg

Department of Oncology, University Hospital of Larissa, Larissa, Greece

Emmanouil Saloustros

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA

Dale P. Sandler & Jack A. Taylor

School of Cancer and Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy’s Campus, King’s College London, London, UK

Elinor J. Sawyer

Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

Rita K. Schmutzler

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA

Xiao-Ou Shu & Wei Zheng

Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia

Melissa C. Southey & Roger L. Milne

Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia

Melissa C. Southey

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia

Melissa C. Southey, Robert J. MacInnis & Roger L. Milne

Genetic Epidemiology Group, School of Population and Global Health, University of Western Australia, Perth, WA, Australia

Jennifer Stone

Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA

Jack A. Taylor

Department of Clinical Genetics, The Netherlands Cancer Institute - Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Irma van de Beek

Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA

Celine M. Vachon

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Marjanka K. Schmidt

Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Marjanka K. Schmidt

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands

Marjanka K. Schmidt

Department of Oncology, Södersjukhuset, Stockholm, Sweden

Per Hall

Department of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, CA, USA

Paul D. P. Pharoah

Genomics Center, Centre Hospitalier Universitaire de Québec – Université Laval Research Center, Québec City, QC, Canada

Jacques Simard

Writing Group: KY, KMi, DFE, ACA, NMa, and JSi; Study design: KMi, DFE, ACA, NMa, JSi, and KY; Data management: MKB, QW; Statistical Analysis: KY, NMa, JD, MZ, DFE, KMi; Provided data: MA, TUA, ILA, HA-C, NNA, VA, KJA, AAu, ABat, SBe, MBerm, ABer, KBia, NB, CBo, NVB, SEB, KBr, HBra, HBre, NJC, FC, JEC, JC-C, GC-T, WKC, NBCS Collaborators, SVC, FJC, ACox, SSC, KCz, MBD, PD, TD, AMD, DME, AHE, CEn, ME, DGE, PAF, OF, HF, MG-D, AG-M, AG-N, PGu, EHah, CAH, PHall, UH, JMH, VH, JH, AHol, EHon, MJH, RH, JLHo, SH, AHow, ABCTB Investigators, kConFab Investigators, SJ, AJak, HJ, NJ, RKa, EKK, CMKi, SKou, VNK, JVL, DLa, FLej, ALin, MLus, RJM, AMan, DM, UM, RLM, RAM, HNe, NOb, KOf, T-WP-S, AVP, CP, PPe, PDPP, GPi, DPK, KPy, PRa, MUR, GR, ER, JR, ARo, EHR, ES, DPS, EJS, MKS, RKS, CSc, X-OS, MCS, JSt, JAT, LRT, CMV, IVDB, WW, RWi, WZ, JSi, ACA, DFE. All authors read and approved the final version of the manuscript.