Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women

Bissell MCS, Kerlikowske K, Sprague BL, Tice JA, Gard CC, Tossas KY, et al. Breast cancer population attributable risk proportions associated with body mass index and breast density by race/ethnicity and menopausal status. Cancer Epidemiol Biomarkers Prev. 2020;29:2048–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alimujiang A, Imm KR, Appleton CM, Colditz GA, Berkey CS, Toriola AT. Adiposity at age 10 and mammographic density among premenopausal women. Cancer Prev Res. 2018;11:287–94.

Article  Google Scholar 

Alimujiang A, Appleton C, Colditz GA, Toriola AT. Adiposity during early adulthood, changes in adiposity during adulthood, attained adiposity, and mammographic density among premenopausal women. Breast Cancer Res Treat. 2017;166:197–206. https://doi.org/10.1007/s10549-017-4384-4.

Article  PubMed  Google Scholar 

Moore JX, Han Y, Appleton C, Colditz G, Toriola AT. Determinants of mammographic breast density by race among a large screening population. JNCI Cancer Spectr. 2020. https://doi.org/10.1093/jncics/pkaa010/5758266.

Article  PubMed  PubMed Central  Google Scholar 

Dettmer K, Aronov PA, Hammock BD. Mass spectrometry-based metabolomics. Mass Spectrom Rev. 2007;26:51–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mcclain KM, Friedenreich CM, Matthews CE, Sampson JN, Check DP, Brenner DR, et al. Body composition and metabolomics in the Alberta physical activity and breast cancer prevention trial. J Nutr. 2022;152:419–28. https://doi.org/10.1093/jn/nxab388.

Article  CAS  PubMed  Google Scholar 

Stevens VL, Carter BD, McCullough ML, Campbell PT, Wang Y. Metabolomic profiles associated with BMI, waist circumference, and diabetes and inflammation biomarkers in women. Obesity. 2020;28:187–96.

Article  CAS  PubMed  Google Scholar 

Carayol M, Leitzmann MF, Ferrari P, Zamora-Ros R, Achaintre D, Stepien M, et al. Blood metabolic signatures of body mass index: a targeted metabolomics study in the EPIC cohort. J Proteome Res. 2017;16:3137–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quehenberger O, Dennis EA. The human plasma lipidome. N Engl J Med. 2011;365:1812–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerl MJ, Klose C, Surma MA, Fernandez C, Melander O, Männistö S, et al. Machine learning of human plasma lipidomes for obesity estimation in a large population cohort. PLoS Biol. 2019;17:1–25.

Article  Google Scholar 

Rauschert S, Uhl O, Koletzko B, Kirchberg F, Mori TA, Huang RC, et al. Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults. J Clin Endocrinol Metab. 2016;101:871–9.

Article  CAS  PubMed  Google Scholar 

Yin R, Wang X, Li K, Yu K, Yang L. Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students. BMC Endocr Disord. 2021;21:1–10.

Article  Google Scholar 

Wang Y, Jiang CT, Song JY, Song QY, Ma J, Wang HJ. Lipidomic profile revealed the association of plasma lysophosphatidylcholines with adolescent obesity. Biomed Res Int. 2019;2019:1–9.

CAS  Google Scholar 

Beyene HB, Olshansky G, Smith AAT, Giles C, Huynh K, Cinel M, et al. High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: evidence from two large population cohort studies. PLoS Biol. 2020. https://doi.org/10.1371/journal.pbio.3000870.

Article  PubMed  PubMed Central  Google Scholar 

Matthew KA, Getz KR, Jeon MS, Luo C, Luo J, Toriola AT. Associations of vitamins and related cofactor metabolites with mammographic breast density in premenopausal women. J Nutr. 2024;154:424–34.

Article  CAS  PubMed  Google Scholar 

Jung S, Silva S, Dallal CM, LeBlanc E, Paris K, Shepherd J, et al. Untargeted serum metabolomic profiles and breast density in young women. Cancer Causes Control. 2024;35:323–34. https://doi.org/10.1007/s10552-023-01793-w.

Article  PubMed  Google Scholar 

Getz KR, Jeon MS, Luo C, Luo J, Toriola AT. Lipidome of mammographic breast density in premenopausal women. Breast Cancer Res. 2023;25:1–13. https://doi.org/10.1186/s13058-023-01725-1.

Article  CAS  Google Scholar 

Dorgan JF, Baer HJ, Bertrand KA, LeBlanc ES, Jung S, Magder LS, et al. Childhood adiposity, serum metabolites and breast density in young women. Breast Cancer Res. 2022;24:1–11. https://doi.org/10.1186/s13058-022-01588-y.

Article  CAS  Google Scholar 

Toriola AT, Appleton CM, Zong X, Luo J, Weilbaecher K, Tamimi RM, et al. Circulating receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), and mammographic density in premenopausal women. Cancer Prev Res. 2018;11:789–96.

Article  CAS  Google Scholar 

Berkey CS, Rockett HRH, Field AE, Gillman MW, Frazier AL, Camargo CA, et al. Activity, dietary intake, and weight changes in a longitudinal study of preadolescent and adolescent boys and girls. Pediatrics. 2000;105:e56–e56.

Article  CAS  PubMed  Google Scholar 

Metabolon. Complex Lipids Targeted Panel. [cited 2023 May 18]. Available from: https://www.metabolon.com/lp/complex-lipid-panel/

Hastie T, Tibshirani R, Narasimhan B, Chu G. Impute: impute: imputation for microarray data_.R package version 1.70.0. 2022.

Collet TH, Sonoyama T, Henning E, Keogh JM, Ingram B, Kelway S, et al. A metabolomic signature of acute caloric restriction. J Clin Endocrinol Metab. 2017;102:4486–95.

Article  PubMed  PubMed Central  Google Scholar 

Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, Tibshirani R, et al. Missing value estimation methods for DNA microarrays. Bioinformatics. 2001;17:520–5.

Article  CAS  PubMed  Google Scholar 

Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 2007;8:118–27.

Article  PubMed  Google Scholar 

van Buuren S, Groothuis-Oudshoorn K. Mice: multivariate imputation by chained equations in R. J Stat Softw. 2011. https://doi.org/10.18637/jss.v045.i03.

Article  Google Scholar 

Zhang H, Zheng Y, Zhang Z, Gao T, Joyce B, Yoon G, et al. Estimating and testing high-dimensional mediation effects in epigenetic studies. Bioinformatics. 2016;32:3150–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moore SC, Matthews CE, Sampson JN, Stolzenberg-Solomon RZ, Zheng W, Cai Q, et al. Human metabolic correlates of body mass index. Metabolomics. 2014;10:259–69.

Article  CAS  PubMed  Google Scholar 

Butte NF, Liu Y, Zakeri IF, Mohney RP, Mehta N, Voruganti VS, et al. Global metabolomic profiling targeting childhood obesity in the Hispanic population. Am J Clin Nutr. 2015;102:256–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Müllner E, Röhnisch HE, von Brömssen C, Moazzami AA. Metabolomics analysis reveals altered metabolites in lean compared with obese adolescents and additional metabolic shifts associated with hyperinsulinaemia and insulin resistance in obese adolescents: a cross-sectional study. Metabolomics. 2021;17:1–13.

Article  Google Scholar 

Maltais-Payette I, Boulet M-M, Prehn C, Adamski J, Tchernof A. Circulating glutamate concentration as a biomarker of visceral obesity and associated metabolic alterations. Nutr Metab. 2018;15:78.

Article  CAS  Google Scholar 

Maltais-Payette I, Allam-Ndoul B, Pérusse L, Vohl M-C, Tchernof A. Circulating glutamate level as a potential biomarker for abdominal obesity and metabolic risk. Nutr Metab Cardiovasc Dis. 2019;29:1353–60.

Article  CAS  PubMed  Google Scholar 

Nagao H, Nishizawa H, Bamba T, Nakayama Y, Isozumi N, Nagamori S, et al. Increased dynamics of tricarboxylic acid cycle and glutamate synthesis in obese adipose tissue: in vivo metabolic turnover analysis. J Biol Chem. 2017;292:4469–83.

Article  CAS  PubMed 

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