Monzel AS, Enríquez JA, Picard M. Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction. Nat Metab. 2023;5(4):546–62.

Article  PubMed  PubMed Central  Google Scholar 

Spinelli JB, Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nat Cell Biol. 2018;20(7):745–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martínez-Reyes I, Chandel NS. Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun. 2020;11(1):102.

Article  PubMed  PubMed Central  Google Scholar 

Boardman NT, Trani G, Scalabrin M, Romanello V, Wüst RCI. Intracellular to interorgan mitochondrial communication in striated muscle in health and disease. Endocr Rev. 2023;44(4):668–92.

Article  PubMed  PubMed Central  Google Scholar 

Guo J, Huang X, Dou L, Yan M, Shen T, Tang W, et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Ther. 2022;7(1):391.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019;571(7764):183–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guarente L, Sinclair DA, Kroemer G. Human trials exploring anti-aging medicines. Cell Metab. 2024;36(2):354–76.

Article  CAS  PubMed  Google Scholar 

Salvioli S, Basile MS, Bencivenga L, Carrino S, Conte M, Damanti S, et al. Biomarkers of aging in frailty and age-associated disorders: state of the art and future perspective. Ageing Res Rev. 2023;91: 102044.

Article  CAS  PubMed  Google Scholar 

Son JM, Lee C. Aging: all roads lead to mitochondria. Semin Cell Dev Biol. 2021;116:160–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Copeland DE, Dalton AJ. An association between mitochondria and the endoplasmic reticulum in cells of the pseudobranch gland of a teleost. J Biophys Biochem Cytol. 1959;5(3):393–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vance JE. Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem. 1990;265(13):7248–56.

Article  CAS  PubMed  Google Scholar 

Csordás G, Renken C, Várnai P, Walter L, Weaver D, Buttle KF, et al. Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol. 2006;174(7):915–21.

Article  PubMed  PubMed Central  Google Scholar 

Ding Y, Liu N, Zhang D, Guo L, Shang Q, Liu Y, et al. Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases. Front Pharmacol. 2024;15:1398381.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Q, Qu M, Shen T, Su J, Xu Y, Xu C, et al. Control of mitochondria-associated endoplasmic reticulum membranes by protein S-palmitoylation: novel therapeutic targets for neurodegenerative diseases. Ageing Res Rev. 2023;87: 101920.

Article  CAS  PubMed  Google Scholar 

Janikiewicz J, Szymański J, Malinska D, Patalas-Krawczyk P, Michalska B, Duszyński J, et al. Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. Cell Death Dis. 2018;9(3):332.

Article  PubMed  PubMed Central  Google Scholar 

Jin C, Kumar P, Gracia-Sancho J, Dufour JF. Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases. FEBS Lett. 2021;595(10):1411–21.

Article  CAS  PubMed  Google Scholar 

D’Eletto M, Rossin F, Occhigrossi L, Farrace MG, Faccenda D, Desai R, et al. Transglutaminase type 2 regulates ER-mitochondria contact sites by interacting with GRP75. Cell Rep. 2018;25(13):3573-3581.e4.

Article  PubMed  Google Scholar 

Yuan M, Gong M, He J, Xie B, Zhang Z, Meng L, et al. IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling. Redox Biol. 2022;52: 102289.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, et al. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nat Commun. 2014;5:3996.

Article  CAS  PubMed  Google Scholar 

Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, et al. The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med. 2011;3(88):88ra55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan DC. Mitochondrial dynamics and its involvement in disease. Annu Rev Pathol. 2020;15:235–59.

Article  CAS  PubMed  Google Scholar 

de Brito OM, Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. 2008;456(7222):605–10.

Article  PubMed  Google Scholar 

Filadi R, Greotti E, Turacchio G, Luini A, Pozzan T, Pizzo P. Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling. Proc Natl Acad Sci USA. 2015;112(17):E2174–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yedida G, Milani M, Cohen GM, Varadarajan S. Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis. Cell Death Dis. 2019;10(7):521.

Article  PubMed  PubMed Central  Google Scholar 

Stone SJ, Vance JE. Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. J Biol Chem. 2000;275(44):34534–40.

Article  CAS  PubMed  Google Scholar 

Hernández-Alvarez MI, Sebastián D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, et al. Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease. Cell. 2019;177(4):881-895.e17.

Article  PubMed  Google Scholar 

Barazzuol L, Giamogante F, Brini M, Calì T. PINK1/Parkin mediated mitophagy, Ca(2+) signalling, and ER-mitochondria contacts in Parkinson’s disease. Int J Mol Sci. 2020;21(5):1772.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gelmetti V, De Rosa P, Torosantucci L, Marini ES, Romagnoli A, Di Rienzo M, et al. PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation. Autophagy. 2017;13(4):654–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Z, Yang L, Zhang M, Tang H, Huang Y, Su Y, et al. A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development. Cell Metab. 2024;36(7):1586-1597.e7.

Article  CAS  PubMed  Google Scholar 

Zhu D, Li X, Tian Y. Mitochondrial-to-nuclear communication in aging: an epigenetic perspective. Trends Biochem Sci. 2022;47(8):645–59.

Article