Braet F, Wisse E. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. Comp Hepatol. 2002. https://doi.org/10.1186/1476-5926-1-1.

Article  PubMed  PubMed Central  Google Scholar 

Szafranska K, Holte CF, Kruse LD, McCourt P, Zapotoczny B. The wHole story about fenestrations in liver sinusoidal endothelial cells. Front Physiol. 2021. https://doi.org/10.3389/fphys.2021.735573.

Article  PubMed  PubMed Central  Google Scholar 

Gracia-Sancho J, Caparrós E, Fernández-Iglesias A, Francés R. Role of liver sinusoidal endothelial cells in liver diseases. Nat Rev Gastroenterol Hepatol. 2021;18:411–31.

Article  PubMed  Google Scholar 

Hunt NJ, McCourt PAG, Le Couteur DG, Cogger VC. Novel targets for delaying aging: the importance of the liver and advances in drug delivery. Adv Drug Deliv Rev. 2018;135:39–49.

Article  PubMed  CAS  Google Scholar 

Cogger VC, Hilmer SN, Sullivan D, Muller M, Fraser R, Le Couteur DG. Hyperlipidemia and surfactants: the liver sieve is a link. Atherosclerosis. 2006;189:273–81.

Article  PubMed  CAS  Google Scholar 

Herrnberger L, Hennig R, Kremer W, Hellerbrand C, Goepferich A, Kalbitzer HR, et al. Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage. PLoS ONE. 2014;9:1–26.

Article  Google Scholar 

Fraser R, Dobbs BR, Rogers GWT. Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis. Hepatology. 1995;21:863–74.

PubMed  CAS  Google Scholar 

Fraser R, Cogger VC, Dobbs B, Jamieson H, Warren A, Hilmer SN, et al. The liver sieve and atherosclerosis. Pathology. 2012;44:181–6.

Article  PubMed  CAS  Google Scholar 

Jamieson HA, Cogger VC, Twigg SM, McLennan SV, Warren A, Cheluvappa R, et al. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia. 2007;50:1969–76.

Article  PubMed  CAS  Google Scholar 

Wojnar-Lason K, Tyrankiewicz U, Kij A, Kurpinska A, Kaczara P, Kwiatkowski G, et al. Chronic heart failure induces early defenestration of liver sinusoidal endothelial cells (LSECs) in mice. Acta Physiol. 2024;1:21.

Google Scholar 

Cheluvappa R, Cogger VC, Kwun SY, O’Reilly JN, Le Couteur DG, Hilmer SN. Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. Int J Exp Pathol. 2008;89:410–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheluvappa R, Denning GM, Lau GW, Grimm MC, Hilmer SN, Le Couteur DG. Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. Int J Infect Dis. 2010;14:e857–67.

Article  PubMed  CAS  Google Scholar 

Le Couteur DG, Warren A, Cogger VC, Smedsrød B, Sørensen KK, De Cabo R, et al. Old age and the hepatic sinusoid. Anat Rec. 2008;291:672–83.

Article  Google Scholar 

Le Couteur DG, Cogger VC, Markus AMA, Harvey PJ, Yin ZL, Ansselin AD, et al. Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology. 2001;33:537–43.

Article  PubMed  Google Scholar 

Fernández-Iglesias A, Gracia-Sancho J. Chapter 23 - Role of liver sinusoidal endothelial cells in the diagnosis and treatment of liver diseases. In: Gracia-Sancho J, editor. Sinusoidal Cells in Liver Diseases. Academic Press: Cambridge; 2024. p. 467–81.

Chapter  Google Scholar 

Furrer K, Rickenbacher A, Tian Y, Jochum W, Bittermann AG, Kach A, et al. Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway. Proc Natl Acad Sci. 2011;108:2945–50.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gracia-Sancho J. Chapter 4—Liver sinusoidal cells in aging. In: Gracia-Sancho J, editor. Sinusoidal Cells in Liver Diseases. Academic Press: Cambridge; 2024. p. 77–87.

Chapter  Google Scholar 

Wisse E. An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids. J Ultrasructure Res. 1970;31:125–50.

Article  CAS  Google Scholar 

Yokomori H, Yoshimura K, Funakoshi S, Nagai T, Fujimaki K, Nomura M, et al. Rho modulates hepatic sinusoidal endothelial fenestrae via regulation of the actin cytoskeleton in rat endothelial cells. Lab Investig. 2004;84:857–64.

Article  PubMed  CAS  Google Scholar 

Zapotoczny B, Szafranska K, Lekka M, Ahluwalia BS, McCourt P. Tuning of liver sieve : the interplay between actin and myosin regulatory light chain regulates fenestration size and number in murine liver sinusoidal endothelial cells. Int J Mol Sci. 2022;23:1–21.

Article  Google Scholar 

Svistounov D, Warren A, Mcnerney GP, Owen DM, Zencak D, Le DG, et al. The relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells. PLoS ONE. 2012;7:1–9.

Article  Google Scholar 

Di Martino J, Mascalchi P, Legros P, Lacomme S, Gontier E, Bioulac-Sage P, et al. Actin depolymerization in dedifferentiated liver sinusoidal endothelial cells promotes fenestrae re-formation. Hepatol Commun. 2019;3:213–9.

Article  PubMed  Google Scholar 

Mao H, Szafranska K, Kruse L, Holte C, Wolfson DL, Ahluwalia BS, et al. Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure. Sci Rep. 2023;13:1–13.

Article  Google Scholar 

Hunt NJ, Lockwood G, Warren A, Mao H, McCourt P, Le Couteur DG, et al. Manipulating fenestrations in young and old liver sinusoidal endothelial cells. Am J Physiol Gastrointest Liver Physiol. 2018;144:54.

Google Scholar 

Braet F, De Zanger R, Kalle W, Raap A, Tanke H, Wisse E. Comparative scanning, transmission and atomic force microscopy of the microtubular cytoskeleton in fenestrated liver endothelial cells. Scanning Microsc Suppl. 1996;10:225–35.

PubMed  CAS  Google Scholar 

Mizgalska D, Wgrzyn P, Murzyn K, Kasza A, Koj A, Jura J, et al. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1β mRNA. FEBS J. 2009;276:7386–99.

Article  PubMed  CAS  Google Scholar 

Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, et al. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature. 2009;458:1185–90.

Article  PubMed  CAS  Google Scholar 

Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q, et al. MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling. J Exp Med. 2010;207:2959–73.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Żurawek D, Pydyn N, Major P, Szade K, Trzos K, Kus E, et al. Diosmetin alleviates liver inflammation by improving liver sinusoidal endothelial cell dysfunction. bioRxiv. 2023;20:95.

Google Scholar 

Dobosz E, Lorenz G, Ribeiro A, Wurf V, Wadowska M, Kotlinowski J, et al. Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation. DMM Dis Model Mech. 2021. https://doi.org/10.1242/dmm.047589.

Article  PubMed  Google Scholar 

Szukala W, Pilarczyk-Zurek M, Folkert J, Kotlinowski J, Koziel J, Jura J. Depletion of Mcpip1 in murine myeloid cells results in intestinal dysbiosis followed by allergic inflammation. Biochim Biophys Acta Mol Basis Dis. 2023;1869: 166764.

Article  PubMed  CAS  Google Scholar 

Pydyn N, Żurawek D, Kozieł J, Kus E, Wojnar-Lason K, Jasztal A, et al. Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts. FEBS J. 2021;288:6563–80.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li Y, Huang X, Huang S, He H, Lei T, Saaoud F, et al. Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury. Signal Transduct Target Ther. 2017. https://doi.org/10.1038/sigtrans.2017.66.

Article  PubMed  PubMed Central  Google Scholar 

Wadowska M, Dobosz E, Golda A, Bryzek D, Lech M, Fu M, et al. MCP-induced protein 1 participates in macrophage-dependent endotoxin tolerance. J Immunol. 2022;209:1348–58.

Article  PubMed