Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan

Abraham R.T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177‒2196.

Article  CAS  PubMed  Google Scholar 

Paull T.T. 2015. Mechanisms of ATM activation. Annu. Rev. Biochem. 84, 711‒738.

Article  CAS  PubMed  Google Scholar 

Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R., 3rd, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. 2007. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 316, 1160‒1166.

Article  CAS  PubMed  Google Scholar 

Shibata A., Jeggo P.A. 2021. ATM’s role in the repair of DNA double-strand breaks. Genes. 12 (9),1370.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X., Wan G., Berger F.G., He X., Lu X. 2011. The ATM kinase induces microRNA biogenesis in the DNA damage response. Mol. Cell. 41, 371‒383.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J., Jin T., Ran L., Zhao Z., Zhu R., Xie G., Bi X. 2022. Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation. Hereditas. 159, 41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rothblum-Oviatt C., Wright J., Lefton-Greif M.A., McGrath-Morrow S.A., Crawford T.O., Lederman H.M. 2016. Ataxia telangiectasia: A review. Orphanet. J. Rare Dis. 11, 159.

Article  PubMed  PubMed Central  Google Scholar 

Chaudhary M.W., Al-Baradie R.S. 2014. Ataxia-telangiectasia: Future prospects. Appl. Clin. Genet. 7, 159–167.

PubMed  PubMed Central  Google Scholar 

Barlow C., Hirotsune S., Paylor R., Liyanage M., Eckhaus M., Collins F., Shiloh Y., Crawley J.N., Ried T., Tagle D., Wynshaw-Boris A. 1996. Atm-deficient mice: A paradigm of ataxia telangiectasia. Cell. 86, 159‒171.

Article  CAS  PubMed  Google Scholar 

Quek H., Luff J., Cheung K., Kozlov S., Gatei M., Lee C.S., Bellingham M.C., Noakes P.G., Lim Y.C., Barnett N.L., Dingwall S., Wolvetang E., Mashimo T., Roberts T.L., Lavin M.F. 2017. A rat model of ataxia-telangiectasia: Evidence for a neurodegenerative phenotype. Hum. Mol. Genet. 26, 109‒123.

CAS  PubMed  Google Scholar 

Chen K., Wang P., Chen J., Ying Y., Chen Y., Gilson E., Lu Y., Ye J. 2022. Loss of atm in zebrafish as a model of ataxia-telangiectasia syndrome. Biomedicines. 10 (2), 392.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petersen A.J., Rimkus S.A., Wassarman D.A. 2012. ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 109, E656‒E664.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petersen A.J., Katzenberger R.J., Wassarman D.A. 2013. The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia. Genetics. 194, 133‒142.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silva E., Tiong S., Pedersen M., Homola E., Royou A., Fasulo B., Siriaco G., Campbell S.D. 2004. ATM is required for telomere maintenance and chromosome stability during Drosophila development. Curr. Biol. 14, 1341‒1347.

Article  CAS  PubMed  Google Scholar 

Chen T., Dong B., Lu Z., Tian B., Zhang J., Zhou J., Wu H., Zhang Y., Wu J., Lin P., Zhang J., Xu H., Mo X. 2010. A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. Mech. Ageing Dev. 131, 636–640.

Article  CAS  PubMed  Google Scholar 

Piaceri I., Bagnoli S., Tedde A., Sorbi S., Nacmias B. 2013. Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians. Neurol. Sci. 34, 573–575.

Article  PubMed  Google Scholar 

Fu S., Hu J., Chen X., Li B., Shun H., Deng J., Zhang Y., Yao Y., Zhao Y. 2021. Mutant single nucleotide polymorphism rs189037 in ataxia-telangiectasia mutated gene is significantly associated with ventricular wall thickness and human lifespan. Front. Cardiovasc. Med. 8, 658908.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ditch S., Paull T.T. 2012. The ATM protein kinase and cellular redox signaling: Beyond the DNA damage response. Trends Biochem. Sci. 37, 15‒22.

Article  CAS  PubMed  Google Scholar 

Amirifar P., Ranjouri M.R., Yazdani R., Abolhassani H., Aghamohammadi A. 2019. Ataxia-telangiectasia: A review of clinical features and molecular pathology. Pediatr. Allergy Immunol. 30, 277‒288.

Article  PubMed  Google Scholar 

Valentin-Vega Y.A., Maclean K.H., Tait-Mulder J., Milasta S., Steeves M., Dorsey F.C., Cleveland J.L., Green D.R., Kastan M.B. 2012. Mitochondrial dysfunction in ataxia-telangiectasia. Blood. 119, 1490‒1500.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirozane T., Tohmonda T., Yoda M., Shimoda M., Kanai Y., Matsumoto M., Morioka H., Nakamura M., Horiuchi K. 2016. Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass. Sci. Rep. 6, 34426.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weitering T.J., Takada S., Weemaes C.M.R., van Schouwenburg P.A., van der Burg M. 2021. ATM: Translating the DNA damage response to adaptive immunity. Trends Immunol. 42, 350‒365.

Article  CAS  PubMed  Google Scholar 

Stagni V., Cirotti C., Barilà D. 2018. Ataxia-telangiectasia mutated kinase in the control of oxidative stress, mitochondria, and autophagy in cancer: A maestro with a large orchestra. Front. Oncol. 8, 73.

Article  PubMed  PubMed Central  Google Scholar 

Stagni V., Ferri A., Cirotti C., Barilà D. 2020. ATM kinase-dependent regulation of autophagy: A key player in senescence? Front. Cell Dev. Biol. 8, 599048.

Article  PubMed  Google Scholar 

Osorio F.G., Barcena C., Soria-Valles C., Ramsay A.J., de Carlos F., Cobo J., Fueyo A., Freije J.M., Lopez-Otin C. 2012. Nuclear lamina defects cause ATM-dependent NF-kappaB activation and link accelerated aging to a systemic inflammatory response. Genes Dev. 26, 2311–2324.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee S.S., Bohrson C., Pike A.M., Wheelan S.J., Greider C.W. 2015. ATM kinase is required for telomere elongation in mouse and human cells. Cell Rep. 13, 1623‒1632.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang H.T., Park J.T., Choi K., Kim Y., Choi H.J.C., Jung C.W., Lee Y.S., Park S.C. 2017. Chemical screening identifies ATM as a target for alleviating senescence. Nat. Chem. Biol. 13, 616–623.

Article  CAS  PubMed  Google Scholar 

Kuk M.U., Kim J.W., Lee Y.S., Cho K.A., Park J.T., Park S.C. 2019. Alleviation of senescence via ATM inhibition in accelerated aging models. Mol. Cells. 42, 210–217.

CAS  PubMed  PubMed Central  Google Scholar 

Hari K.L., Santerre A., Sekelsky J.J., McKim K.S., Boyd J.B., Hawley R.S. 1995. The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell. 82, 815–821.

Article  CAS  PubMed  Google Scholar 

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