Collisson E.A., Bailey P., Chang D.K., Biankin A.V. 2019. Molecular subtypes of pancreatic cancer. Nat. Rev. Gastroenterol. Hepatol. 16, 207–220.
Rawla P., Sunkara T., Gaduputi V. 2019. Epidemiology of pancreatic cancer: Global trends, etiology and risk factors. World J. Oncol. 10, 10–27.
Article PubMed Central PubMed Google Scholar
Kung H.C., Yu J. 2023. Targeted therapy for pancreatic ductal adenocarcinoma: Mechanisms and clinical study. MedComm. 4, e216.
Article CAS PubMed Central PubMed Google Scholar
Pandey S., Gupta V.K., Lavania S.P. 2023. Role of epigenetics in pancreatic ductal adenocarcinoma. Epigenomics. 15, 89–110.
Article CAS PubMed Google Scholar
Hafner A., Boettiger A. 2023. The spatial organization of transcriptional control. Nat. Rev. Genet. 24, 53–68.
Article CAS PubMed Google Scholar
van Roey R., Brabletz T., Stemmler M.P., Armstark I. 2021. Deregulation of transcription factor networks driving cell plasticity and metastasis in pancreatic cancer. Front. Cell Dev. Biol. 9, 753456.
Article PubMed Central PubMed Google Scholar
Diaferia G.R., Balestrieri C., Prosperini E., Nicoli P., Spaggiari P., Zerbi A., Natoli G. 2016. Dissection of transcriptional and cis-regulatory control of differentiation in human pancreatic cancer. EMBO J. 35, 595–617.
Article CAS PubMed Central PubMed Google Scholar
Abjalimov I.R., Zinovyeva M.V., Nikolaev L.G., Kopantzeva M.R., Kopantzev E.P., Sverdlov E.D. 2017. Expression of transcription factor genes in cell lines corresponding to different stages of pancreatic cancer progression. Dokl. Biochem. Biophys. 475, 267–270.
Article CAS PubMed Google Scholar
Luo Y., Chen C. 2021. The roles and regulation of the KLF5 transcription factor in cancers. Cancer Sci. 112, 2097–2117.
Article CAS PubMed Central PubMed Google Scholar
Zinovyeva M.V., Kostina M.B., Chernov I.P., Kondratyeva L.G., Sverdlov E.D. 2016. KLF5, a new player and new target in the permanently changing set of pancreatic cancer molecular drivers. Russ. J. Bioorg. Chem. 42, 606‒611.
Hoskins J.W., Ibrahim A., Emmanuel M.A., Manmiller S.M., Wu Y., O’Neill M., Jia J., Collins I., Zhang M., Thomas J.V., Rost L.M., Das S., Parikh H., Haake J.M., Matters G.L., Kurtz R.C., Bamlet W.R., Klein A., Stolzenberg-Solomon R., Wolpin B.M., Yarden R., Wang Z., Smith J., Olson S.H., Andresson T., Petersen G.M., Amundadottir L.T. 2016. Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression. Hum. Mol. Genet. 25, 4726–4738.
CAS PubMed Central PubMed Google Scholar
Wolpin B.M., Rizzato C., Kraft P., Kooperberg C., Petersen G.M., Wang Z., Arslan A.A., Beane-Freeman L., Bracci P.M., Buring J., Canzian F., Duell E.J., Gallinger S., Giles G.G., Goodman G.E., Goodman P.J., Jacobs E.J., Kamineni A., Klein A.P., Kolonel L.N., Kulke M.H., Li D., Malats N., Olson S.H., Risch H.A., Sesso H.D., Visvanathan K., White E., Zheng W., Abnet C.C., Albanes D., Andreotti G., Austin M.A., Barfield R., Basso D., Berndt S.I., Boutron-Ruault M.C., Brotzman M., Buchler M.W., Bueno-de-Mesquita H.B., Bugert P., Burdette L., Campa D., Caporaso N.E., Capurso G., Chung C., Cotterchio M., Costello E., Elena J., Funel N., Gaziano J.M., Giese N.A., Giovannucci E.L., Goggins M., Gorman M.J., Gross M., Haiman C.A., Hassan M., Helzlsouer K.J., Henderson B.E., Holly E.A., Hu N., Hunter D.J., Innocenti F., Jenab M., Kaaks R., Key T.J., Khaw K.T., Klein E.A., Kogevinas M., Krogh V., Kupcinskas J., Kurtz R.C., LaCroix A., Landi M.T., Landi S., Le Marchand L., Mambrini A., Mannisto S., Milne R.L., Nakamura Y., Oberg A.L., Owzar K., Patel A.V., Peeters P.H., Peters U., Pezzilli R., Piepoli A., Porta M., Real F.X., Riboli E., Rothman N., Scarpa A., Shu X.O., Silverman D.T., Soucek P., Sund M., Talar-Wojnarowska R., Taylor P.R., Theodoropoulos G.E., Thornquist M., Tjonneland A., Tobias G.S., Trichopoulos D., Vodicka P., Wactawski-Wende J., Wentzensen N., Wu C., Yu H., Yu K., Zeleniuch-Jacquotte A., Hoover R., Hartge P., Fuchs C., Chanock S.J., Stolzenberg-Solomon R.S., Amundadottir L.T. 2014. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat. Genet. 46, 994–1000.
Article CAS PubMed Central PubMed Google Scholar
Petersen G.M., Amundadottir L., Fuchs C.S., Kraft P., Stolzenberg-Solomon R.Z., Jacobs K.B., Arslan A.A., Bueno-de-Mesquita H.B., Gallinger S., Gross M., Helzlsouer K., Holly E.A., Jacobs E.J., Klein A.P., LaCroix A., Li D., Mandelson M.T., Olson S.H., Risch H.A., Zheng W., Albanes D., Bamlet W.R., Berg C.D., Boutron-Ruault M.C., Buring J.E., Bracci P.M., Canzian F., Clipp S., Cotterchio M., de Andrade M., Duell E.J., Gaziano J.M., Giovannucci E.L., Goggins M., Hallmans G., Hankinson S.E., Hassan M., Howard B., Hunter D.J., Hutchinson A., Jenab M., Kaaks R., Kooperberg C., Krogh V., Kurtz R.C., Lynch S.M., McWilliams R.R., Mendelsohn J.B., Michaud D.S., Parikh H., Patel A.V., Peeters P.H., Rajkovic A., Riboli E., Rodriguez L., Seminara D., Shu X.O., Thomas G., Tjonneland A., Tobias G.S., Trichopoulos D., Van Den Eeden S.K., Virtamo J., Wactawski-Wende J., Wang Z., Wolpin B.M., Yu H., Yu K., Zeleniuch-Jacquotte A., Fraumeni J.F., Jr., Hoover R.N., Hartge P., Chanock S.J. 2010. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat. Genet. 42, 224–228.
Article CAS PubMed Central PubMed Google Scholar
Zhang Y., Yao C., Ju Z., Jiao D., Hu D., Qi L., Liu S., Wu X., Zhao C. 2023. Kruppel-like factors in tumors: Key regulators and therapeutic avenues. Front. Oncol. 13, 1080720.
Article CAS PubMed Central PubMed Google Scholar
Palioura D., Lazou A., Drosatos K. 2022. Kruppel-like factor (KLF)5: An emerging foe of cardiovascular health. J. Mol. Cell. Cardiol. 163, 56–66.
Article CAS PubMed Google Scholar
Li J., Liu L., Zhou W.Q., Cai L., Xu Z.G., Rane M.J. 2021. Roles of Kruppel-like factor 5 in kidney disease. J. Cell. Mol. Med. 25, 2342–2355.
Article CAS PubMed Central PubMed Google Scholar
He P., Yang J.W., Yang V.W., Bialkowska A.B. 2018. Kruppel-like factor 5, increased in pancreatic ductal adenocarcinoma, promotes proliferation, acinar-to-ductal metaplasia, pancreatic intraepithelial neoplasia, and tumor growth in mice. Gastroenterology. 154, 1494–1508. e1413.
van de Werken H.J., de Vree P.J., Splinter E., Holwerda S.J., Klous P., de Wit E., de Laat W. 2012. 4C technology: Protocols and data analysis. Meth. Enzymol. 513, 89–112.
Mihara N., Chiba T., Yamaguchi K., Sudo H., Yagishita H., Imai K. 2017. Minimal essential region for kruppel-like factor 5 expression and the regulation by specificity protein 3-GC box binding. Gene. 601, 36–43.
Article CAS PubMed Google Scholar
Shen W., Le S., Li Y., Hu F. 2016. SeqKit: A cross-platform and ultrafast toolkit for FASTA/Q file manipulation. PLoS One. 11, e0163962.
Article PubMed Central PubMed Google Scholar
Langmead B., Trapnell C., Pop M., Salzberg S.L. 2009. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25.
Article PubMed Central PubMed Google Scholar
Li H., Handsaker B., Wysoker A., Fennell T., Ruan J., Homer N., Marth G., Abecasis G., Durbin R. 2009. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 25, 2078–2079.
Article PubMed Central PubMed Google Scholar
Thongjuea S., Stadhouders R., Grosveld F.G., Soler E., Lenhard B. 2013. r3Cseq: An R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data. Nucleic Acids Res. 41, e132.
Article CAS PubMed Central PubMed Google Scholar
Klein F.A., Pakozdi T., Anders S., Ghavi-Helm Y., Furlong E.E., Huber W. 2015. FourCSeq: Analysis of 4C sequencing data. Bioinformatics. 31, 3085–3091.
Article CAS PubMed Central PubMed Google Scholar
Geeven G., Teunissen H., de Laat W., de Wit E. 2018. peakC: A flexible, non-parametric peak calling package for 4C and Capture-C data. Nucleic Acids Res. 46, e91.
Article PubMed Central PubMed Google Scholar
Raviram R., Rocha P.P., Muller C.L., Miraldi E.R., Badri S., Fu Y., Swanzey E., Proudhon C., Snetkova V., Bonneau R., Skok J.A. 2016. 4C-ker: A method to reproducibly identify genome-wide interactions captured by 4C-Seq experiments. PLoS Comput. Biol. 12, e1004780.
Article PubMed Central PubMed Google Scholar
Kent W.J., Sugnet C.W., Furey T.S., Roskin K.M., Pringle T.H., Zahler A.M., Haussler D. 2002. The human genome browser at UCSC. Genome Res. 12, 996–1006.
留言 (0)