Morozova E., Kulikova V., Rodionov A., Revtovich S., Anufrieva N., Demidkina T. 2016. Engineered Citrobacter freundii methionine γ-lyase effectively produces antimicrobial thiosulfinates. Biochimie. 128‒129, 92‒98.

Article  PubMed  Google Scholar 

Iciek M., Kwiecień I., Włodek L. 2009. Biological properties of garlic and garlic-derived organosulfur compounds. Environ. Mol. Mutagenesis. 50, 247−265.

Article  CAS  Google Scholar 

Jacob C. 2006. A scent of therapy: Pharmacological implications of natural products containing redox-active sulfur atoms. Nat. Prod. Rep. 23, 851−863.

Article  CAS  PubMed  Google Scholar 

Kim S., Kubec R., Musah R.A. 2006. Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L. J. Ethnopharmacol. 104, 188−192.

Article  CAS  PubMed  Google Scholar 

Kulikova V.V., Anufrieva N.V., Revtovich S.V., Chernov A.S., Telegin G.B., Morozova E.A., Demidkina T.V. 2016. Mutant form C115H of Clostridium sporogenes methionine γ-lyase efficiently cleaves S-alk(en)yl-L-cysteine sulfoxides to antibacterial thiosulfinates. IUBMB Life. 68, 830–835.

Article  CAS  PubMed  Google Scholar 

Leontiev R., Hohaus N., Jacob C., Gruhlke M.C.H., Slusarenko A.J. 2018. A comparison of the antibacterial and antifungal activities of thiosulfinate analogues of allicin. Sci. Rep. 8, 6763.

Article  PubMed  PubMed Central  Google Scholar 

Revtovich S., Lyfenko A., Tkachev Y., Kulikova V., Koval V., Puchkov V., Anufrieva N., Solyev P., Morozova E. 2023. Anticandidal activity of in situ methionine γ-lyase-based thiosulfinate generation system vs. synthetic thiosulfinates. Pharmaceuticals (Basel). 16(12), 1695.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Small L.D., Bailey J.H., Cavallito C.J. 1947. Alkyl thiolsulfinates. J. Am. Chem. Soc. 69, 1710−1717.

Article  CAS  PubMed  Google Scholar 

Kulikova V.V., Chernukha M.Y., Morozova E.A., Revtovich S.V., Rodionov A.N., Koval V.S., Avetisyan L.R., Kuliastova D.G., Shaginyan I.A. 2018. Antibacterial effect of thiosulfinates on multiresistant strains of bacteria isolated from patients with cystic fibrosis. Acta Naturae. 10, 77−80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anraku Y., Kishimura A., Kamiya M., Tanaka S., Nomoto T., Toh K., Matsumoto Y., Fukushima S., Sueyoshi D., Kano M.R., Urano Y., Nishiyama N., Kataoka K. 2016. Systemically injectable enzyme-loa-ded polyion complex vesicles as in vivo nanoreactors functioning in tumors. Angew. Chem. Int. Ed. Engl. 55, 560‒565.

Article  CAS  PubMed  Google Scholar 

Kulikova V.V., Morozova E.A., Anufrieva N.V., Koval V.S., Lyfenko A.D., Lesnova E.I., Kushch A.A., Revtovich S.V., Demidkina T.V. 2022. Kinetic and pharmacokinetic characteristics of therapeutic methionine γ-lyase encapsulated in polyion complex vesicles. Biochemie. 194, 13‒18.

Article  CAS  Google Scholar 

Morozova E., Kulikova V., Koval V., Anufrieva N., Chernukha M., Avetisyan L., Lebedeva L., Med-vedeva O., Burmistrov E., Shaginyan I., Revtovich S., Demidkina T. 2020. Encapsulated methionine γ-lyase: Application in enzyme prodrug therapy of Pseudomonas aeruginosa infection. ACS Omega. 5, 7782−7786.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morozova E., Koval V., Revtovich S., Lyfenko A., Minakov A., Chernov A., Telegin G., Kirilenko D., Chobanian A., Anufrieva N., Kulikova V., Demidkina T. 2023. Phytoestrogens decorated nanocapsules for the-rapeutic methionine γ-lyase targeted delivery. Biochimie. 209, 1‒9.

Article  CAS  PubMed  Google Scholar 

Mironov A.N. 2012. Rukovodstvo po provedeniyu do-klinicheskikh issledovanii lekarstvennykh sredstv. (Guidelines for Preclinical Trials of Medicinal Products). Part 1. Moscow: Grif i K.

Miron T., Rabinkov A., Mirelman D., Weiner L., Wilchek M. 1998. A spectrophotometric assay for allicin and alliinase (alliin lyase) activity: Reaction of 2-nitro-5-thiobenzoate with thiosulfinates. Anal. Biochem. 265, 317‒325.

Article  CAS  PubMed  Google Scholar 

Koval V., Morozova E., Revtovich S., Lyfenko A., Chobanian A., Timofeeva V., Solovieva A., Anufrieva N., Kulikova V., Demidkina T. 2022. Characteristics and stability assessment of therapeutic methionine γ-lyase-loaded polyionic vesicles. ACS Omega. 7, 959‒967.

Article  CAS  PubMed  Google Scholar 

Laemmli U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227, 680‒685.

Article  CAS  PubMed  Google Scholar 

Morozova E.A., Bazhulina N.P., Anufrieva N.V., Mamaeva D.V., Tkachev Y.V., Streltsov S.A., Timofeev V.P., Faleev N.G., Demidkina T.V. 2010. K-inetic and spectral parameters of interaction of Citrobacter freundii methionine γ-lyase with amino acids. Biochemistry (Moscow). 75, 1272–1280.

CAS  PubMed  Google Scholar 

Organization for Economic Cooperation and Development (OECD). 2008. Guidelines for the Testing of Che-micals and Food Ingredients. Section 4 (Part 407). Paris, France.

Mennecozzi M., Landesmann B., Palosaari T., Harris G., Whelan M. 2015. Sex differences in liver to-xicity—do female and male human primary hepatocytes react differently to toxicants in vitro? PLoS One. 10 (4), e0122786.

Article  PubMed  PubMed Central  Google Scholar 

American Veterinary Medical Association, 2020. AVMA Guidelines for the Euthanasia of Animals. Sc-haumburg (IL), USA. ISBN 978-1-882691-09-8

Google Scholar 

Mann P.C., Vahle J., Keenan C.M., Baker J.F., Bradley A.E., Goodman D.G., Harada T., Herbert R., Kaufmann W., Kellner R., Nolte T., Rittinghausen S., Tanaka T. 2012. International harmonization of toxicologic pathology: Nomenclature: an overview and review of basic principles. Toxicol. Pathol. 40, 7S‒13S.

Article  PubMed  Google Scholar 

Kyung K.H., Fleming H.P. 1994. S-Methyl-L-cysteine sulfoxide as the precursor of methyl methanethiolsulfinate, the principal antibacterial compound in cabbage. J. Food Sci. 59, 350–355.

Article  CAS  Google Scholar