Activation of GPR30 Ameliorates Cerebral Ischemia–Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway

Chen, J., Yang, L., Geng, L., He, J., Chen, L., Sun, Q., Zhao, J., & Wang, X. (2021). Inhibition of Acyl-CoA synthetase long-chain family member 4 facilitates neurological recovery after stroke by regulation ferroptosis. Frontiers in Cellular Neuroscience, 15, 632354.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan, C., Wang, L., Zhang, J., Xiang, X., Wu, Y., Zhang, Z., Li, Q., Tian, K., Xue, M., Liu, L., et al. (2020). Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity. Redox Biology, 37, 101706.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadjimarkou, M. M., & Vasudevan, N. (2018). GPER1/GPR30 in the brain: Crosstalk with classical estrogen receptors and implications for behavior. The Journal of Steroid Biochemistry and Molecular Biology, 176, 57–64.

Article  CAS  PubMed  Google Scholar 

Han, X., Zhang, J., Liu, J., Wang, H., Du, F., Zeng, X., & Guo, C. (2022). Targeting ferroptosis: A novel insight against myocardial infarction and ischemia–reperfusion injuries. Apoptosis, 28(1–2), 108–123.

PubMed  Google Scholar 

Hazell, G. G. J., Yao, S. T., Roper, J. A., Prossnitz, E. R., O’Carroll, A.-M., & Lolait, S. J. (2009). Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. Journal of Endocrinology, 202(2), 223–236.

Article  CAS  PubMed  Google Scholar 

Jiang, X., Stockwell, B. R., & Conrad, M. (2021). Ferroptosis: Mechanisms, biology and role in disease. Nature Reviews Molecular Cell Biology, 22(4), 266–282.

Article  PubMed  PubMed Central  Google Scholar 

Jurcau, A., & Simion, A. (2021). Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: From pathophysiology to therapeutic strategies. International Journal of Molecular Sciences, 23(1), 78.

Article  Google Scholar 

Li, C., Wu, Y., Chen, Q., Luo, Y., Liu, P., Zhou, Z., Zhao, Z., Zhang, T., Su, B., Sun, T., et al. (2023). Pleiotropic microenvironment remodeling micelles for cerebral ischemia-reperfusion injury therapy by inhibiting neuronal ferroptosis and glial overactivation. ACS Nano, 17(18), 18164–18177.

Article  CAS  PubMed  Google Scholar 

Li, Y., Chopp, M., Chen, J., Wang, L., Gautam, S. C., Xu, Y. X., Zhang, Z., et al. (2000). Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. Journal of Cerebral Blood Flow and Metabolism, 20(9), 1311–1319.

Article  CAS  PubMed  Google Scholar 

Liu S-b, Zhang N, Guo Y-y, Zhao R, Shi T-y, Feng S-f, Wang S-q, Yang Q, Li X-q, Wu Y-m et al: G-Protein-Coupled Receptor 30 Mediates Rapid Neuroprotective Effects of Estrogen via Depression of NR2B-Containing NMDA Receptors. The Journal of Neuroscience 2012, 32(14):4887–4900.

Liu, T., Li, X., Cui, Y., Meng, P., Zeng, G., Wang, Q., & Wang, Y. (2021). Bioinformatics analysis identifies potential ferroptosis key genes in the pathogenesis of intracerebral hemorrhage. Frontiers in Neuroscience, 15, 661663.

Article  PubMed  PubMed Central  Google Scholar 

Murata, T., Dietrich, H. H., Xiang, C., & Dacey, R. G. (2013). G protein-coupled estrogen receptor agonist improves cerebral microvascular function after hypoxia/reoxygenation injury in male and female rats. Stroke, 44(3), 779–785.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Olde, B., & Leeb-Lundberg, L. M. F. (2009). GPR30/GPER1: Searching for a role in estrogen physiology. Trends in Endocrinology & Metabolism, 20(8), 409–416.

Article  CAS  Google Scholar 

Roque, C., Mendes-Oliveira, J., Duarte-Chendo, C., & Baltazar, G. (2019). The role of G protein-coupled estrogen receptor 1 on neurological disorders. Frontiers in Neuroendocrinology, 55, 100786.

Article  CAS  PubMed  Google Scholar 

Stockwell, B. R. (2022). Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell, 185(14), 2401–2421.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017). Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell, 171(2), 273–285.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tuo, Q. Z., Lei, P., Jackman, K. A., Li, X., Xiong, H., Li, X., Liuyang, Z. Y., Roisman, L., Zhang, S. T., Ayton, S., et al. (2017). Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Molecular Psychiatry, 22(11), 1520–1530.

Article  CAS  PubMed  Google Scholar 

Wang, L., Zhang, X., Xiong, X., Zhu, H., Chen, R., Zhang, S., Chen, G., & Jian, Z. (2022). Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke. Antioxidants, 11(12), 78.

Article  Google Scholar 

Wang, X. S., Yue, J., Hu, L. N., Tian, Z., Zhang, K., Yang, L., Zhang, H. N., Guo, Y. Y., Feng, B., Liu, H. Y., et al. (2019). Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes. Glia, 68(1), 27–43.

Article  PubMed  Google Scholar 

Wu, S., Wu, B., Liu, M., Chen, Z., Wang, W., Anderson, C. S., Sandercock, P., Wang, Y., Huang, Y., Cui, L., et al. (2019). Stroke in China: Advances and challenges in epidemiology, prevention, and management. The Lancet Neurology, 18(4), 394–405.

Article  PubMed  Google Scholar 

Xu, Y., Li, K., Zhao, Y., Zhou, L., Liu, Y., & Zhao, J. (2022). Role of ferroptosis in stroke. Cellular and Molecular Neurobiology, 43(1), 205–222.

Article  PubMed  Google Scholar 

Yang, S., Wang, H., Yang, Y., Wang, R., Wang, Y., Wu, C., & Du, G. (2019). Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage. Biomedicine & Pharmacotherapy, 117, 109102.

Article  CAS  Google Scholar 

Zhang, Y., Lu, X., Tai, B., Li, W., & Li, T. (2021). Ferroptosis and Its multifaceted roles in cerebral stroke. Frontiers in Cellular Neuroscience, 15, 615372.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, Y., Ye, P., Zhu, H., Gu, L., Li, Y., Feng, S., Zeng, Z., Chen, Q., Zhou, B., & Xiong, X. (2024). Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia–reperfusion injury by inhibiting ferroptosis-mediated neuroinflammation via the NRF2/HO-1 signaling pathway. CNS Neuroscience & Therapeutics, 30(3), e14456.

Article  CAS  Google Scholar 

Zhang, Z., Qin, P., Deng, Y., Ma, Z., Guo, H., Guo, H., Hou, Y., Wang, S., Zou, W., Sun, Y., et al. (2018). The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation. Journal of Neuroinflammation, 15(1), 78.

Article  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif