Abdi, S., Alghamdi, A. A., AlGhunaim, N. N. A., Almutairi, R. M., Ataya, F. S., Ansari, M. G. A., et al. (2022). Association of Alzheimer’s disease with genetic variants of apolipoprotein E, clusterin, TNF-α, and IL-6 among elderly Saudis. Current Pharmaceutical Biotechnology. https://doi.org/10.2174/1389201023666220208093919

Article  PubMed  Google Scholar 

Aflatoonian, M., Sivandzadeh, G., Morovati-Sharifabad, M., Mirjalili, S. R., Akbarian-Bafghi, M. J., & Neamatzadeh, H. (2019). Associations of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with susceptibility to celiac disease: Evidence from a meta-analysis and literature review. Arquivos De Gastroenterologia. https://doi.org/10.1590/s0004-2803.201900000-60

Article  PubMed  Google Scholar 

Akbulut, U., Çebi, A. H., Saǧ, E., Ikbal, M., & Çakir, M. (2017). Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children. Turkish Journal of Gastroenterology. https://doi.org/10.5152/tjg.2017.17092

Article  Google Scholar 

Anderson, T. W., & Darling, D. A. (1954). A test of goodness of fit. Journal of the American Statistical Association, 49(268), 765–769. https://doi.org/10.1080/01621459.1954.10501232

Article  Google Scholar 

Arosio, B., Trabattoni, D., Galimberti, L., Bucciarelli, P., Fasano, F., Calabresi, C., et al. (2004). Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer’s disease. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2003.10.009

Article  PubMed  Google Scholar 

Babić Leko, M., Nikolac Perković, M., Klepac, N., Štrac, D. Š, Borovečki, F., Pivac, N., et al. (2020). IL-1β, IL-6, IL-10, and TNFα single nucleotide polymorphisms in human influence the susceptibility to Alzheimer’s disease pathology. Journal of Alzheimer’s Disease. https://doi.org/10.3233/JAD-200056

Article  PubMed  PubMed Central  Google Scholar 

Bagli, M., Papassotiropoulos, A., Knapp, M., Jessen, F., Luise Rao, M., Maier, W., & Heun, R. (2000). Association between an interleukin-6 promoter and 3’ flanking region haplotype and reduced Alzheimer’s disease risk in a German population. Neuroscience Letters. https://doi.org/10.1016/S0304-3940(00)00917-4

Article  PubMed  Google Scholar 

Barartabar, Z., Nikzamir, A., Sirati-Sabet, M., Aghamohammadi, E., Chaleshi, V., Rostami Nejad, M., et al. (2018). The relationship between 174 G/C and -572 G/C of IL-6 gene polymorphisms and susceptibility of celiac disease in the Iranian population. Przeglad Gastroenterologiczny. https://doi.org/10.5114/pg.2018.79808

Article  PubMed  PubMed Central  Google Scholar 

Barisani, D., Ceroni, S., Meneveri, R., Cesana, B. M., & Bardella, M. T. (2006). IL-10 polymorphisms are associated with early-onset celiac disease and severe mucosal damage in patients of Caucasian origin. Genetics in Medicine. https://doi.org/10.1097/01.gim.0000204464.87540.39

Article  PubMed  Google Scholar 

Begg, C. B., & Mazumdar, M. (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50(4), 1088. https://doi.org/10.2307/2533446

Article  CAS  PubMed  Google Scholar 

Bhojak, T. J., Dekosky, S. T., Ganguli, M., & Kamboh, M. I. (2000). Genetic polymorphisms in the cathespin D and interleukin-6 genes and the risk of Alzheimer’s disease. Neuroscience Letters. https://doi.org/10.1016/S0304-3940(00)01185-X

Article  PubMed  Google Scholar 

Capurso, C., Solfrizzi, V., Colacicco, A. M., D’Introno, A., Frisardi, V., Imbimbo, B. P., et al. (2010). Interleukin 6–174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer’s disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/j.pnpbp.2009.10.022

Article  PubMed  Google Scholar 

Chen, S. Y., Chen, T. F., Lai, L. C., Chen, J. H., Sun, Y., Wen, L. L., et al. (2012). Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer’s disease. Journal of Neuroinflammation. https://doi.org/10.1186/1742-2094-9-21

Article  PubMed  PubMed Central  Google Scholar 

Chen, Z., Zhang, G., & Li, J. (2015). Goodness-of-fit test for meta-analysis. Scientific Reports, 5, 1–8. https://doi.org/10.1038/srep16983

Article  CAS  Google Scholar 

Child, A., & Foundation, N. (n.d.). 1 in 5 children will live with a neurologic condition, 1–8.

Chu, K., Zhou, X., & Luo, B. Y. (2012). Cytokine gene polymorphisms and Parkinson’s disease: a meta-analysis. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. https://doi.org/10.1017/s0317167100012695

Article  PubMed  Google Scholar 

Cochran, W. G. (1954). The combination of estimates from different experiments. Biometrics. https://doi.org/10.2307/3001666

Article  Google Scholar 

Cojocaru, I. M., Cojocaru, M., Miu, G., & Sapira, V. (2011). Study of interleukin-6 production in Alzheimer’s disease. Romanian Journal of Internal Medicine = Revue Roumaine de Médecine Interne, 49(1), 55.

CAS  PubMed  Google Scholar 

Combarros, O., Warden, D. R., Hammond, N., Cortina-Borja, M., Belbin, O., Lehmann, M. G., et al. (2010). The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer’s disease in the Epistasis Project. BMC Medical Genetics. https://doi.org/10.1186/1471-2350-11-162

Article  PubMed  PubMed Central  Google Scholar 

Cousin, E., Macé, S., Rocher, C., Dib, C., Muzard, G., Hannequin, D., et al. (2011). No replication of genetic association between candidate polymorphisms and Alzheimer’s disease. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2009.09.004

Article  PubMed  Google Scholar 

Cramer, H. (1930). On some classes of series used in mathematical statistics. On the composition of elementary errors. First paper: Mathematical deductions. Second paper: Statistical applications. Journal of the Royal Statistical Society. https://doi.org/10.2307/2342071

Article  Google Scholar 

de Albuquerque Maranhão, R. M., Martins Esteves, F. A., Crovella, S., Segat, L., & Eleutério Souza, P. R. (2015). Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in italian patients. Genetics and Molecular Research. https://doi.org/10.4238/2015.December.9.2

Article  PubMed  Google Scholar 

Debnath, M., Mitra, B., Bera, N. K., Chaudhuri, T. K., Zhang, Y., & ping. (2013). Lack of association of IL-6 (-174 G>C) and TNF-α (-238 G>A) variants with paranoid schizophrenia in Indian Bengalee population. Cytokine. https://doi.org/10.1016/j.cyto.2012.10.028

Article  PubMed  Google Scholar 

Dema, B., Martínez, A., Fernández-Arquero, M., Maluenda, C., Polanco, I., Figueredo, M. Á., et al. (2009). The IL6 -174G/C polymorphism is associated with celiac disease susceptibility in girls. Human Immunology. https://doi.org/10.1016/j.humimm.2009.01.010

Article  PubMed  Google Scholar 

Depboylu, C., Lohmüller, F., Gocke, P., Du, Y., Zimmer, R., Gasser, T., et al. (2004). An interleukin-6 promoter variant is not associated with an increased risk for Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders. https://doi.org/10.1159/000076352

Article  PubMed  Google Scholar 

Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. British Medical Journal, 315(7109), 629–634. https://doi.org/10.1136/bmj.315.7109.629

Article  CAS  PubMed  PubMed Central  Google Scholar 

Engel, L. S., Taioli, E., Pfeiffer, R., Garcia-Closas, M., Marcus, P. M., Lan, Q., et al. (2002). Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: A HuGE review. American Journal of Epidemiology. https://doi.org/10.1093/aje/kwf018

Article  PubMed  Google Scholar 

Eriksson, U. K., Pedersen, N. L., Reynolds, C. A., Hong, M. G., Prince, J. A., Gatz, M., et al. (2011). Associations of gene sequence variation and serum levels of C-Reactive protein and interleukin-6 with Alzheimer’s disease and dementia. Journal of Alzheimer’s Disease. https://doi.org/10.3233/JAD-2010-101671

Article  PubMed  Google Scholar 

Erta, M., Quintana, A., & Hidalgo, J. (2012). Interleukin-6, a major cytokine in the central nervous system. International Journal of Biological Sciences. https://doi.org/10.7150/ijbs.4679

Article  PubMed  PubMed Central  Google Scholar 

Faltraco, F., Bürger, K., Zill, P., Teipel, S. J., Möller, H. J., Hampel, H., et al. (2003). Interleukin-6-174 G/C promoter gene polymorphism C allele reduces Alzheimer’s disease risk [6]. Journal of the American Geriatrics Society. https://doi.org/10.1046/j.1532-5415.2003.51177.x

Article  PubMed  Google Scholar 

Feigin, V. L., Nichols, E., Alam, T., Bannick, M. S., Beghi, E., Blake, N., et al. (2019). Global, regional, and national burden of neurological disorders, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 18(5), 459–480. https://doi.org/10.1016/S1474-4422(18)30499-X

Article  Google Scholar 

Flex, A., Giovannini, S., Biscetti, F., Liperoti, R., Spalletta, G., Straface, G., et al. (2014). Effect of proinflammatory gene polymorphisms on the risk of Alzheimer’s disease. Neurodegenerative Diseases.