Abbracchio, M. P., Burnstock, G., Verkhratsky, A., & Zimmermann, H. (2009). Purinergic signalling in the nervous system: An overview. Trends in Neurosciences, 32(1), 19–29. https://doi.org/10.1016/j.tins.2008.10.001

Article  PubMed  Google Scholar 

Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., Gehn, E., Loresto, M., Mitchell, J., Atwood, S., Barnhouse, S., & Lee, W. (2011). Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition & Metabolism (London), 8(1), 34. https://doi.org/10.1186/1743-7075-8-34

Article  Google Scholar 

Adzic, M., & Nedeljkovic, N. (2018). Unveiling the role of ecto-5′-nucleotidase/CD73 in astrocyte migration by using pharmacological tools. Frontiers in Pharmacology, 9, 153. https://doi.org/10.3389/fphar.2018.00153

Article  PubMed  PubMed Central  Google Scholar 

Alpert, A. J. (1990). Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. Journal of Chromatography A, 499, 177–196. https://doi.org/10.1016/S0021-9673(00)96972-3

Article  Google Scholar 

Barker, A. J., & Ullian, E. M. (2008). New roles for astrocytes in developing synaptic circuits. Communicative & Integrative Biology, 1(2), 207–211. https://doi.org/10.4161/cib.1.2.7284.PMID:19513261;PMCID:PMC2686024

Article  Google Scholar 

Cheng, C., Lau, S. K. M., & Doering, L. C. (2016). Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model. Molecular Brain, 9, 74. https://doi.org/10.1186/s13041-016-0256-9

Article  PubMed  PubMed Central  Google Scholar 

D’Antoni, S., de Bari, L., Valenti, D., Borro, M., Bonaccorso, C. M., Simmaco, M., Vacca, R. A., & Catania, M. V. (2020). Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome. Biological Chemistry, 401(4), 497–503. https://doi.org/10.1515/hsz-2019-0221

Article  PubMed  Google Scholar 

Dobolyi, A., Juhasz, G., Kovacs, Z., & Kardos, J. (2011). Uridine function in the central nervous system. Current Topics in Medicinal Chemistry, 11(8), 1058–1067. https://doi.org/10.2174/156802611795347618

Article  PubMed  Google Scholar 

Farzin, F., Perry, H., Hessl, D., Loesch, D., Cohen, J., Bacalman, S., Gane, L., Tassone, F., Hagerman, P., & Hagerman, R. (2006). Autism spectrum disorders and attention-deficit/hyperactivity disorder in boys with the fragile X premutation. Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S137-144. https://doi.org/10.1097/00004703-200604002-00012

Article  PubMed  Google Scholar 

Galeano Garcia, P., Zimmermann, B. H., & Carazzone, C. (2019). hydrophilic interaction liquid chromatography coupled to mass spectrometry and multivariate analysis of the de novo pyrimidine pathway metabolites. Biomolecules. https://doi.org/10.3390/biom9080328

Article  PubMed  PubMed Central  Google Scholar 

Gradisnik, L., & Velnar, T. (2023). Astrocytes in the central nervous system and their functions in health and disease: A review. World Journal of Clinical Cases, 11(15), 3385–3394. https://doi.org/10.12998/wjcc.v11.i15.3385. PMID: 37383914; PMCID: PMC10294192.

Article  PubMed  PubMed Central  Google Scholar 

Guang, S., Pang, N., Deng, X., Yang, L., He, F., Wu, L., Chen, C., Yin, F., & Peng, J. (2018). Synaptopathology involved in autism spectrum disorder. Frontiers in Cellular Neuroscience, 21(12), 470. https://doi.org/10.3389/fncel.2018.00470.PMID:30627085;PMCID:PMC6309163

Article  Google Scholar 

Hemström, P., & Irgum, K. (2006). Hydrophilic interaction chromatography. Journal of Separation Science, 29(12), 1784–1821. https://doi.org/10.1002/jssc.200600199

Article  PubMed  Google Scholar 

Higashimori, H., Schin, C. S., Chiang, M. S., Morel, L., Shoneye, T. A., Nelson, D. L., & Yang, Y. (2016). Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo. Journal of Neuroscience, 36(27), 7079–7094. https://doi.org/10.1523/jneurosci.1069-16.2016

Article  PubMed  Google Scholar 

Hodges, J. L., Yu, X., Gilmore, A., Bennett, H., Tjia, M., Perna, J. F., Chen, C. C., Li, X., Lu, J., & Zuo, Y. (2017). Astrocytic contributions to synaptic and learning abnormalities in a mouse model of fragile X syndrome. Biological Psychiatry, 82(2), 139–149. https://doi.org/10.1016/j.biopsych.2016.08.036

Article  PubMed  Google Scholar 

Huang, Z., Xie, N., Illes, P., Di Virgilio, F., Ulrich, H., Semyanov, A., Verkhratsky, A., Sperlagh, B., Yu, S. G., Huang, C., & Tang, Y. (2021). From purines to purinergic signalling: molecular functions and human diseases. Signal Transduction and Targeted Therapy, 6, 162. https://doi.org/10.1038/s41392-021-00553-z

Article  PubMed  PubMed Central  Google Scholar 

Jacobs, S., & Doering, L. C. (2009). Primary dissociated astrocyte and neuron co-culture. In L. C. Doering (Ed.), Protocols for neural cell culture (4th ed., pp. 269–284). Humana.

Chapter  Google Scholar 

Jacobs, S., & Doering, L. C. (2010). Astrocytes prevent abnormal neuronal development in the fragile X mouse. The Journal of Neuroscience, 30(12), 4508–4514. https://doi.org/10.1523/jneurosci.5027-09.2010

Article  PubMed  PubMed Central  Google Scholar 

Kong, Z., Jia, S., Chabes, A. L., Appelblad, P., Lundmark, R., Moritz, T., & Chabes, A. (2018). Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry. Nucleic Acids Research, 46(11), e66–e66. https://doi.org/10.1093/nar/gky203

Article  PubMed  PubMed Central  Google Scholar 

Li, Y. X., Schaffner, A. E., & Barker, J. L. (1999). Astrocytes regulate the developmental appearance of GABAergic and glutamatergic postsynaptic currents in cultured embryonic rat spinal neurons. European Journal of Neuroscience, 11(7), 2537–51.

Article  PubMed  Google Scholar 

Lie, A. A., Blümcke, I., Beck, H., Wiestler, O. D., Elger, C. E., & Schoen, S. W. (1999). 5’-Nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain. Journal of Neuropathology and Experimental Neurology, 58(5), 451–458. https://doi.org/10.1097/00005072-199905000-00004

Article  PubMed  Google Scholar 

Liu, Q. Y., Schaffner, A. E., Li, Y. X., Dunlap, V., & Barker, J. L. (1996). Upregulation of GABAA current by astrocytes in cultured embryonic rat hippocampal neurons. Journal of Neuroscience, 16(9), 2912–23.

Article  PubMed  Google Scholar 

Musumeci, S. A., Hagerman, R. J., Ferri, R., Bosco, P., Bernardina, B. D., Tassinari, C. A., De Sarro, G. B., & Elia, M. (1999). Epilepsy and EEG findings in males with fragile X syndrome. Epilepsia, 40(8), 1092–1099. https://doi.org/10.1111/j.1528-1157.1999.tb00824.x

Article  PubMed  Google Scholar 

Napier, M., Reynolds, K., & Scott, A. L. (2023). Glial-mediated dysregulation of neurodevelopment in fragile X syndrome. International Review of Neurobiology, 173, 187–215. https://doi.org/10.1016/bs.irn.2023.08.005. Epub 2023 Sep 16 PMID: 37993178.

Article  PubMed  Google Scholar 

Narayan, V. (2017). HPLC analysis of nucleotides (Master of Applied Science (Research)). Queensland University of Technology

Pfrieger, F. W., & Barres, B. A. (1997). Synaptic efficacy enhanced by glial cells in vitro. Science, 277(5332), 1684–7.

Article  PubMed  Google Scholar 

Pieretti, M., Zhang, F. P., Fu, Y. H., Warren, S. T., Oostra, B. A., Caskey, C. T., & Nelson, D. L. (1991). Absence of expression of the FMR-1 gene in fragile X syndrome. Cell, 66(4), 817–822. https://doi.org/10.1016/0092-8674(91)90125-i

Article  PubMed  Google Scholar 

Ren, B., Burkovetskaya, M., Jung, Y., Bergdolt, L., Totusek, S., Martinez-Cerdeno, V., Stauch, K., Korade, Z., & Dunaevsky, A. (2023). Dysregulated cholesterol metabolism, aberrant excitability and altered cell cycle of astrocytes in fragile X syndrome. Glia, 71(5), 1176–1196. https://doi.org/10.1002/glia.24331. Epub 2023 Jan 3. PMID: 36594399; PMCID: PMC10023374.

Article  PubMed  PubMed Central  Google Scholar 

Reynolds, K. E., Huang, E., Sabbineni, M., et al. (2024). Purinergic signalling mediates aberrant excitability of developing neuronal circuits in the Fmr1 knockout mouse model. Molecular Neurobiology. https://doi.org/10.1007/s12035-024-04181-w. PMID: 38652351.

Article  PubMed  Google Scholar 

Reynolds, K. E., Wong, C. R., & Scott, A. L. (2021). Astrocyte-mediated purinergic signaling is upregulated in a mouse model of fragile X syndrome. Glia, 69(7), 1816–1832. https://doi.org/10.1002/glia.23997

Article  PubMed  Google Scholar 

Shen, M., Sirois, C. L., Guo, Y., Li, M., Dong, Q., Méndez-Albelo, N. M., Gao, Y., Khullar, S., Kissel, L., Sandoval, S. O., Wolkoff, N. E., Huang, S. X., Xu, Z., Bryan, J. E., Contractor, A. M., Korabelnikov, T., Glass, I. A., Doherty, D., Birth Defects Research Laboratory, … Zhao, X. (2023). Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development. Neuron, 111(24), 3988–4005. https://doi.org/10.1016/j.neuron.2023.09.014. Epub 2023 Oct 10. PMID: 37820724; PMCID: PMC10841112.

Article