Freret, M. E. & Boire, A. The anatomic basis of leptomeningeal metastasis. J. Exp. Med. 221, e20212121 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robert, S. M. et al. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 186, 764–785 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iram, T. et al. Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17. Nature 605, 509–515 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rustenhoven, J. et al. Functional characterization of the dural sinuses as a neuroimmune interface. Cell 184, 1000–1016 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piehl, N. et al. Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment. Cell 185, 5028–5039 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merlini, A. et al. Distinct roles of the meningeal layers in CNS autoimmunity. Nat. Neurosci. 25, 887–899 (2022).

Article  CAS  PubMed  Google Scholar 

Boire, A. et al. Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis. Cell 168, 1101–1113 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chamberlain, M. C. Leptomeningeal metastasis. Curr. Opin. Oncol. 22, 627–635 (2010).

Article  PubMed  Google Scholar 

Martirosian, V. et al. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 35, 109302 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chi, Y. et al. Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369, 276–282 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilcox, J. A. & Boire, A. A. Leveraging molecular and immune-based therapies in leptomeningeal metastases. CNS Drugs 37, 45–67 (2023).

Article  CAS  PubMed  Google Scholar 

Castellani, G., Croese, T., Peralta Ramos, J. M. & Schwartz, M. Transforming the understanding of brain immunity. Science 380, eabo7649 (2023).

Article  CAS  PubMed  Google Scholar 

Rebejac, J. et al. Meningeal macrophages protect against viral neuroinfection. Immunity 55, 2103–2117 (2022).

Article  CAS  PubMed  Google Scholar 

Pinho-Ribeiro, F. A. et al. Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion. Nature 615, 472–481 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kierdorf, K., Masuda, T., Jordao, M. J. C. & Prinz, M. Macrophages at CNS interfaces: ontogeny and function in health and disease. Nat. Rev. Neurosci. 20, 547–562 (2019).

Article  CAS  PubMed  Google Scholar 

Drieu, A. et al. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature 611, 585–593 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smalley, I. et al. Single-cell characterization of the immune microenvironment of melanoma brain and leptomeningeal metastases. Clin. Cancer Res. 27, 4109–4125 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldmann, T. et al. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat. Immunol. 17, 797–805 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rua, R. et al. Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity. Nat. Immunol. 20, 407–419 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung, S. et al. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106–4114 (2000).

Article  CAS  PubMed  PubMed Central  Google Scholar 

DeNardo, D. G. & Ruffell, B. Macrophages as regulators of tumour immunity and immunotherapy. Nat. Rev. Immunol. 19, 369–382 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Vlaminck, K. et al. Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation. Immunity 55, 2085–2102 (2022).

Article  PubMed  Google Scholar 

Yona, S. et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38, 79–91 (2013).

Article  CAS  PubMed  Google Scholar 

Goldmann, T. et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat. Neurosci. 16, 1618–1626 (2013).

Article  CAS  PubMed  Google Scholar 

Masuda, T. et al. Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature 604, 740–748 (2022).

Article  CAS  PubMed  Google Scholar 

Santisteban, M. M. et al. Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension. Nat. Neurosci. 27, 63–77 (2024).

Article  CAS  PubMed  Google Scholar 

Remsik, J. et al. Leptomeningeal anti-tumor immunity follows unique signaling principles. Preprint at bioRxiv https://doi.org/10.1101/2023.03.17.533041 (2023).

Van Hove, H. et al. A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Nat. Neurosci. 22, 1021–1035 (2019).

Article  PubMed  Google Scholar 

Jordao, M. J. C. et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science 363, eaat7554 (2019).

Article  CAS  PubMed  Google Scholar 

Ochocka, N. et al. Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages. Nat. Commun. 12, 1151 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munro, D. A. D., Movahedi, K. & Priller, J. Macrophage compartmentalization in the brain and cerebrospinal fluid system. Sci. Immunol. 7, eabk0391 (2022).

Article  CAS  PubMed  Google Scholar