ETV7 limits the antiviral and antitumor efficacy of CD8+ T cells by diverting their fate toward exhaustion

Zhang, N. & Bevan, M. J. CD8+ T cells: foot soldiers of the immune system. Immunity 35, 161–168 (2011).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chang, J. T., Wherry, E. J. & Goldrath, A. W. Molecular regulation of effector and memory T cell differentiation. Nat. Immunol. 15, 1104–1115 (2014).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hellstrom, I., Hellstrom, K. E., Pierce, G. E. & Yang, J. P. Cellular and humoral immunity to different types of human neoplasms. Nature 220, 1352–1354 (1968).

Article  PubMed  CAS  Google Scholar 

Hellstrom, K. E. & Hellstrom, I. From the Hellstrom paradox toward cancer cure. Prog. Mol. Biol. Transl. Sci. 164, 1–24 (2019).

Article  PubMed  CAS  Google Scholar 

McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. Rev. Immunol. 37, 457–495 (2019).

Article  PubMed  CAS  Google Scholar 

Philip, M. & Schietinger, A. CD8+ T cell differentiation and dysfunction in cancer. Nat. Rev. Immunol. 22, 209–223 (2022).

Article  PubMed  CAS  Google Scholar 

Schietinger, A. et al. Tumor-specific T cell dysfunction is a dynamic antigen-driven differentiation program initiated early during tumorigenesis. Immunity 45, 389–401 (2016).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Anderson, K. G., Stromnes, I. M. & Greenberg, P. D. Obstacles posed by the tumor microenvironment to T cell activity: a case for synergistic therapies. Cancer Cell 31, 311–325 (2017).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Thommen, D. S. & Schumacher, T. N. T cell dysfunction in cancer. Cancer Cell 33, 547–562 (2018).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sade-Feldman, M. et al. Defining T cell states associated with response to checkpoint immunotherapy in melanoma. Cell 175, 998–1013 (2018).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Im, S. J. et al. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature 537, 417–421 (2016).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Siddiqui, I. et al. Intratumoral TCF1+PD-1+CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy. Immunity 50, 195–211 (2019).

Article  PubMed  CAS  Google Scholar 

Krishna, S. et al. Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer. Science 370, 1328–1334 (2020).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kraehenbuehl, L., Weng, C. H., Eghbali, S., Wolchok, J. D. & Merghoub, T. Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways. Nat. Rev. Clin. Oncol. 19, 37–50 (2022).

Article  PubMed  CAS  Google Scholar 

Chow, A., Perica, K., Klebanoff, C. A. & Wolchok, J. D. Clinical implications of T cell exhaustion for cancer immunotherapy. Nat. Rev. Clin. Oncol. 19, 775–790 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Hou, A. J., Chen, L. C. & Chen, Y. Y. Navigating CAR-T cells through the solid-tumour microenvironment. Nat. Rev. Drug Discov. 20, 531–550 (2021).

Article  PubMed  CAS  Google Scholar 

D’Aloia, M. M., Zizzari, I. G., Sacchetti, B., Pierelli, L. & Alimandi, M. CAR-T cells: the long and winding road to solid tumors. Cell Death Dis. 9, 282 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Newick, K., O’Brien, S., Moon, E. & Albelda, S. M. CAR T cell therapy for solid tumors. Annu. Rev. Med. 68, 139–152 (2017).

Article  PubMed  CAS  Google Scholar 

Zheng, L. et al. Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science 374, abe6474 (2021).

Article  PubMed  Google Scholar 

Kourtis, N. et al. A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma. Nat. Cancer 3, 885–898 (2022).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Satpathy, A. T. et al. Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion. Nat. Biotechnol. 37, 925–936 (2019).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vardhana, S. A. et al. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Nat. Immunol. 21, 1022–1033 (2020).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Balkhi, M. Y., Wittmann, G., Xiong, F. & Junghans, R. P. YY1 upregulates checkpoint receptors and downregulates type I cytokines in exhausted, chronically stimulated human T cells. iScience 2, 105–122 (2018).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Blank, C. U. et al. Defining T cell exhaustion. Nat. Rev. Immunol. 19, 665–674 (2019).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen, Y. et al. BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection. Nat. Immunol. 22, 996–1007 (2021).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Romero, F., Martinez, A. C., Camonis, J. & Rebollo, A. Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. EMBO J. 18, 3419–3430 (1999).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Philip, M. et al. Chromatin states define tumour-specific T cell dysfunction and reprogramming. Nature 545, 452–456 (2017).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Minutti, C. M. et al. Surfactant protein a prevents IFN-γ/IFN-γ receptor interaction and attenuates classical activation of human alveolar macrophages. J Immunol 197, 590–598 (2016).

Article  PubMed  CAS  Google Scholar 

Matz, M. et al. The regulation of interferon type I pathway-related genes RSAD2 and ETV7 specifically indicates antibody-mediated rejection after kidney transplantation. Clin. Transplant 32, e13429 (2018).

Article  PubMed  Google Scholar 

Wang, Y. et al. Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection. Cell Host Microbe 11, 631–642 (2012).

Article  PubMed 

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