Macedo, F. et al. Bone metastases: an overview. Oncol. Rev. 11, 321 (2017).
PubMed PubMed Central Google Scholar
Zhang, W. et al. The bone microenvironment invigorates metastatic seeds for further dissemination. Cell 184, 2471–2486 (2021).
Article CAS PubMed PubMed Central Google Scholar
Huang, Y., Wang, H., Yue, X. & Li, X. Bone serves as a transfer station for secondary dissemination of breast cancer. Bone Res. 11, 21 (2023).
Article PubMed PubMed Central Google Scholar
Engblom, C. et al. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science 358, eaal5081 (2017).
Article PubMed PubMed Central Google Scholar
Giles, A. J. et al. Activation of hematopoietic stem/progenitor cells promotes immunosuppression within the pre-metastatic niche. Cancer Res. 76, 1335–1347 (2016).
Article CAS PubMed Google Scholar
Kaplan, R. N., Psaila, B. & Lyden, D. Bone marrow cells in the ‘pre-metastatic niche’: within bone and beyond. Cancer Metastasis Rev. 25, 521–529 (2006).
Giles, A. J. et al. The functional interplay between systemic cancer and the hematopoietic stem cell niche. Pharmacol. Ther. 168, 53–60 (2016).
Article CAS PubMed PubMed Central Google Scholar
Zacharia, B., Joy, J., Subramaniam, D. & Pai, P. K. Factors affecting life expectancy after bone metastasis in adults — results of a 5-year prospective study. Indian J. Surg. Oncol. 12, 759–769 (2021).
Article PubMed PubMed Central Google Scholar
LaMarche, N. M. et al. An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature 625, 166–174 (2024).
Article CAS PubMed Google Scholar
Akkiraju, H. & Nohe, A. Current challenges in bone biology. Adv. Tech. Biol. Med. 3, 132 (2015).
Article PubMed PubMed Central Google Scholar
Safi, S. et al. Bone marrow expands the repertoire of functional T cells targeting tumor-associated antigens in patients with resectable non-small-cell lung cancer. Oncoimmunology 8, e1671762 (2019).
Article PubMed PubMed Central Google Scholar
Chen, J. Z. & Alt, F. W. Gene rearrangement and B-cell development. Curr. Opin. Immunol. 5, 194–200 (1993).
Article CAS PubMed Google Scholar
Geerman, S., Hickson, S., Brasser, G., Pascutti, M. F. & Nolte, M. A. Quantitative and qualitative analysis of bone marrow CD8+ T cells from different bones uncovers a major contribution of the bone marrow in the vertebrae. Front. Immunol. 6, 660 (2015).
Fornetti, J., Welm, A. L. & Stewart, S. A. Understanding the bone in cancer metastasis. J. Bone Miner. Res. 33, 2099–2113 (2018).
Article CAS PubMed Google Scholar
Lazic, D. et al. Landscape of bone marrow metastasis in human neuroblastoma unraveled by transcriptomics and deep multiplex imaging. Cancers 13, 4311 (2021).
Article CAS PubMed PubMed Central Google Scholar
Lim, W. et al. Real-time in vivo imaging of metastatic bone tumors with a targeted near-infrared fluorophore. Oncotarget 8, 65770–65777 (2017).
Article PubMed PubMed Central Google Scholar
Lecomte, J. et al. Bone marrow-derived myofibroblasts are the providers of pro-invasive matrix metalloproteinase 13 in primary tumor. Neoplasia 14, 943–951 (2012).
Article CAS PubMed PubMed Central Google Scholar
Pittenger, M. F. et al. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen. Med. 4, 22 (2019).
Article PubMed PubMed Central Google Scholar
Pinho, S. & Frenette, P. S. Haematopoietic stem cell activity and interactions with the niche. Nat. Rev. Mol. Cell Biol. 20, 303–320 (2019).
Article CAS PubMed PubMed Central Google Scholar
Sivaraj, K. K. & Adams, R. H. Blood vessel formation and function in bone. Development 143, 2706–2715 (2016).
Article CAS PubMed Google Scholar
Kusumbe, A. P., Ramasamy, S. K. & Adams, R. H. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507, 323–328 (2014).
Article CAS PubMed PubMed Central Google Scholar
Kusumbe, A. P., Ramasamy, S. K., Starsichova, A. & Adams, R. H. Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue. Nat. Protoc. 10, 1904–1914 (2015).
Article CAS PubMed Google Scholar
Stucker, S., Chen, J., Watt, F. E. & Kusumbe, A. P. Bone angiogenesis and vascular niche remodeling in stress, aging, and diseases. Front. Cell Dev. Biol. 8, 602269 (2020).
Article PubMed PubMed Central Google Scholar
Peng, Y., Wu, S., Li, Y. & Crane, J. L. Type H blood vessels in bone modeling and remodeling. Theranostics 10, 426–436 (2020).
Article CAS PubMed PubMed Central Google Scholar
Chen, M. et al. Skeleton–vasculature chain reaction: a novel insight into the mystery of homeostasis. Bone Res. 9, 21 (2021).
Article PubMed PubMed Central Google Scholar
Biswas, L. et al. Lymphatic vessels in bone support regeneration after injury. Cell 186, 382–397 (2023).
Article CAS PubMed Google Scholar
Marrella, A. et al. Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration. Mater. Today 21, 362–376 (2018).
Qin, Q. et al. Neurovascular coupling in bone regeneration. Exp. Mol. Med. 54, 1844–1849 (2022).
Article CAS PubMed PubMed Central Google Scholar
Brazill, J. M., Beeve, A. T., Craft, C. S., Ivanusic, J. J. & Scheller, E. L. Nerves in bone: evolving concepts in pain and anabolism. J. Bone Miner. Res. 34, 1393–1406 (2019).
Wolock, S. L. et al. Mapping distinct bone marrow niche populations and their differentiation paths. Cell Rep. 28, 302–311 (2019).
Article CAS PubMed PubMed Central Google Scholar
Tikhonova, A. N. et al. The bone marrow microenvironment at single-cell resolution. Nature 569, 222–228 (2019).
Article CAS PubMed PubMed Central Google Scholar
Baccin, C. et al. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nat. Cell Biol. 22, 38–48 (2020).
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