Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249 (2021).
Will, M., Liang, J., Metcalfe, C. & Chandarlapaty, S. Therapeutic resistance to anti-oestrogen therapy in breast cancer. Nat. Rev. Cancer 23, 673–685 (2023).
Article PubMed PubMed Central CAS Google Scholar
Mottamal, M., Kang, B., Peng, X. & Wang, G. From pure antagonists to pure degraders of the estrogen receptor: evolving strategies for the same target. ACS Omega 6, 9334–9343 (2021).
Article PubMed PubMed Central CAS Google Scholar
Liang, J. et al. GDC-9545 (giredestrant): a potent and orally bioavailable selective estrogen receptor antagonist and degrader with an exceptional preclinical profile for ER+ breast cancer. J. Med. Chem. 64, 11841–11856 (2021).
Article PubMed CAS Google Scholar
Liang, J. et al. Giredestrant counters a progesterone hypersensitivity program driven by estrogen receptor mutations in breast cancer. Sci. Transl. Med. 14, eabo5959 (2022).
Article PubMed CAS Google Scholar
Martín, M. et al. Giredestrant for estrogen receptor-positive, HER2-negative,previously treated advanced breast cancer: results from the randomized, phase II acelERA Breast Cancer Study. J. Clin. Oncol 42, 2149–2160 (2024).
Toy, W. et al. ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat. Genet. 45, 1439–1445 (2013).
Article PubMed PubMed Central CAS Google Scholar
Robinson, D. R. et al. Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat. Genet. 45, 1446–1451 (2013).
Article PubMed PubMed Central CAS Google Scholar
Jeselsohn, R. et al. Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer. Clin. Cancer Res. 20, 1757–1767 (2014).
Article PubMed PubMed Central CAS Google Scholar
Schiavon, G. et al. Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer. Sci. Transl. Med. 7, 313ra182 (2015).
Article PubMed PubMed Central Google Scholar
Guan, J. et al. Therapeutic ligands antagonize estrogen receptor function by impairing its mobility. Cell 178, 949–963 e918 (2019).
Article PubMed CAS Google Scholar
O’Leary, B. et al. The genetic landscape and clonal evolution of breast cancer resistance to palbociclib plus fulvestrant in the PALOMA-3 trial. Cancer Discov. 8, 1390–1403 (2018).
Article PubMed PubMed Central Google Scholar
Turner, N. C. et al. Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial. Lancet Oncol. 21, 1296–1308 (2020).
Article PubMed PubMed Central CAS Google Scholar
Arnesen, S. et al. Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and secondary effects. Cancer Res. 81, 539–551 (2021).
Article PubMed CAS Google Scholar
Nilsson, M. E. et al. Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry. Endocrinology 156, 2492–2502 (2015).
Article PubMed CAS Google Scholar
Ku, S. Y. et al. Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance. Science 355, 78–83 (2017).
Article PubMed PubMed Central CAS Google Scholar
Bach, K. et al. Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing. Nat. Commun. 8, 2128 (2017).
Article PubMed PubMed Central Google Scholar
Giraddi, R. R. et al. Single-cell transcriptomes distinguish stem cell state changes and lineage specification programs in early mammary gland development. Cell Rep. 24, 1653–1666 (2018).
Article PubMed PubMed Central CAS Google Scholar
Soares, E. & Zhou, H. Master regulatory role of p63 in epidermal development and disease. Cell Mol. Life Sci. 75, 1179–1190 (2018).
Article PubMed CAS Google Scholar
Gatti, V. et al. p63 at the crossroads between stemness and metastasis in breast cancer.Int. J. Mol. Sci. 20, 2683 (2019).
Article PubMed PubMed Central CAS Google Scholar
Visvader, J. E. & Stingl, J. Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev. 28, 1143–1158 (2014).
Article PubMed PubMed Central CAS Google Scholar
Wuidart, A. et al. Early lineage segregation of multipotent embryonic mammary gland progenitors. Nat. Cell Biol. 20, 666–676 (2018).
Article PubMed PubMed Central CAS Google Scholar
Keenan, A. B. et al. ChEA3: transcription factor enrichment analysis by orthogonal omics integration. Nucleic Acids Res. 47, W212–W224 (2019).
Article PubMed PubMed Central CAS Google Scholar
Li, Z. et al. ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation. Nat. Commun 13, 2011 (2022).
Article PubMed PubMed Central CAS Google Scholar
Jhaveri, K. L. et al. Phase Ia/b study of giredestrant ±palbociclib and ±luteinizing hormone-releasing hormone agonists in estrogen receptor-positive, HER2-negative, locally advanced/metastatic breast cancer. Clin. Cancer Res. 30, 754–766 (2024).
Article PubMed CAS Google Scholar
Risom, T. et al. Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma. Cell 185, 299–310 (2022).
Article PubMed PubMed Central CAS Google Scholar
DeRose, Y. S. et al. Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat. Med. 17, 1514–1520 (2011).
Article PubMed PubMed Central CAS Google Scholar
Sikora, M. J. et al. Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response. Cancer Res 74, 1463–1474 (2014).
Article PubMed PubMed Central CAS Google Scholar
Li, S. et al. Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. Cell Rep. 4, 1116–1130 (2013).
Article PubMed CAS Google Scholar
Nguyen, Q. H. et al. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat. Commun. 9, 2028 (2018).
留言 (0)