N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential

Jassim A, Rahrmann EP, Simons BD, et al. Cancers make their own luck: theories of cancer origins. Nat Rev Cancer. 2023;23(10):710–24.

Article  CAS  PubMed  Google Scholar 

Steeg PS. Targeting metastasis. Nat Rev Cancer. 2016;16(4):201–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ring A, Nguyen-Strauli BD, Wicki A, et al. Biology, vulnerabilities and clinical applications of circulating tumour cells. Nat Rev Cancer. 2023;23(2):95–111.

Article  CAS  PubMed  Google Scholar 

Rong D, Sun G, Wu F, et al. Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers. Mol Ther Nucleic Acids. 2021;25:67–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li YJ, Qiu YL, Li MR, et al. New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma. Acta Pharmacol Sin. 2024;45(6):1130–41.

Article  CAS  PubMed  Google Scholar 

Boccaletto P, Stefaniak F, Ray A, et al. MODOMICS: a database of RNA modification pathways. 2021 update. Nucleic Acids Res. 2022, 50(D1):D231-D235.

Schaefer MR. The Regulation of RNA modification systems: the next frontier in epitranscriptomics? Genes (Basel). 2021;12(3):345.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Zhang S, Xia T, et al. RNA Modifications Meet Tumors. Cancer Manag Res. 2022;14:3223–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wiener D, Schwartz S. The epitranscriptome beyond m(6)A. Nat Rev Genet. 2021;22(2):119–31.

Article  CAS  PubMed  Google Scholar 

Xie S, Chen W, Chen K, et al. Emerging roles of RNA methylation in gastrointestinal cancers. Cancer Cell Int. 2020;20(1):585.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adler M, Weissmann B, Gutman AB. Occurrence of methylated purine bases in yeast ribonucleic acid. J Biol Chem. 1958;230(2):717–23.

Article  CAS  PubMed  Google Scholar 

Zhao BS, Roundtree IA, He C. Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 2017;18(1):31–42.

Article  CAS  PubMed  Google Scholar 

Zhao LY, Song J, Liu Y, et al. Mapping the epigenetic modifications of DNA and RNA. Protein Cell. 2020;11(11):792–808.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Jin H, Li Q, et al. The role of RNA methylation in tumor immunity and its potential in immunotherapy. Mol Cancer. 2024;23(1):130.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang D, Han Y, Peng L, et al. Crosstalk between N6-methyladenosine (m6A) modification and noncoding RNA in tumor microenvironment. Int J Biol Sci. 2023;19(7):2198–219.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Furuichi Y. Discovery of m(7)G-cap in eukaryotic mRNAs. Proc Jpn Acad Ser B Phys Biol Sci. 2015;91(8):394–409.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tomikawa C. 7-Methylguanosine modifications in transfer RNA (tRNA). Int J Mol Sci. 2018;19(12):4080.

Article  PubMed  PubMed Central  Google Scholar 

Ramanathan A, Robb GB, Chan SH. mRNA capping: biological functions and applications. Nucleic Acids Res. 2016;44(16):7511–26.

Article  PubMed  PubMed Central  Google Scholar 

Cowling VH. Regulation of mRNA cap methylation. Biochem J. 2009;425(2):295–302.

Article  PubMed  Google Scholar 

Furuichi Y, LaFiandra A, Shatkin AJ. 5’-Terminal structure and mRNA stability. Nature. 1977;266(5599):235–9.

Article  CAS  PubMed  Google Scholar 

Shimotohno K, Kodama Y, Hashimoto J, et al. Importance of 5’-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis. Proc Natl Acad Sci U S A. 1977;74(7):2734–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murthy KG, Park P, Manley JL. A nuclear micrococcal-sensitive, ATP-dependent exoribonuclease degrades uncapped but not capped RNA substrates. Nucleic Acids Res. 1991;19(10):2685–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Wang H, Zhang S, et al. Identification and validation of an m7G-related lncRNAs signature for predicting prognosis, immune response and therapy landscapes in ovarian cancer. Front Genet. 2024;15:1466422.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang LS, Liu C, Ma H, et al. Transcriptome-wide mapping of internal N(7)-methylguanosine methylome in mammalian mRNA. Mol Cell. 2019;74(6):1304-1316 e1308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexandrov A, Martzen MR, Phizicky EM. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. RNA. 2002;8(10):1253–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossi A. Incorporation of uridine by the perfused rabbit heart. Life Sci. 1975;16(7):1121–32.

Article  CAS  PubMed  Google Scholar 

Yang X, Gokulnath P, Lehmann HI, et al. RNA modifications in aging-associated cardiovascular diseases. Aging (Albany NY). 2022;14(19):8110–36.

Article  PubMed  Google Scholar 

Chen Z, Zhu W, Zhu S, et al. METTL1 promotes hepatocarcinogenesis via m(7) G tRNA modification-dependent translation control. Clin Transl Med. 2021;11(12):e661.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma J, Han H, Huang Y, et al. METTL1/WDR4-mediated m(7)G tRNA modifications and m(7)G codon usage promote mRNA translation and lung cancer progression. Mol Ther. 2021;29(12):3422–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ying X, Liu B, Yuan Z, et al. METTL1-m(7) G-EGFR/EFEMP1 axis promotes the bladder cancer development. Clin Transl Med. 2021;11(12):e675.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katsara O, Schneider RJ. m(7)G tRNA modification reveals new secrets in the translational regulation of cancer development. Mol Cell. 2021;81(16):3243–5.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif