Collaborators GCRF. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the global burden of disease study 2019. Lancet. 2022;400(10352):563–91.

Article  Google Scholar 

Ganesh K. Uncoupling Metastasis from Tumorigenesis. N Engl J Med. 2023;388(7):657–9.

Article  PubMed  PubMed Central  Google Scholar 

Li R, Liu X, Huang X, Zhang D, Chen Z, Zhang J, et al. Single-cell transcriptomic analysis deciphers heterogenous cancer stem-like cells in colorectal cancer and their organ-specific metastasis. Gut. 2024;73(3):470–84.

CAS  PubMed  Google Scholar 

Chiang AC, Massagué J. Molecular basis of metastasis. N Engl J Med. 2008;359(26):2814–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu Y, Lyu C, Li X, Yang L, Wang J, Li H, et al. Remodeling of tumor microenvironment by extracellular matrix protein 1a differentially regulates ovarian cancer metastasis. Cancer Lett. 2024;596: 217022.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Donaher JL, Das S, Li X, Reinhardt F, Krall JA, et al. Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Nat Cell Biol. 2022;24(4):554–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ebrahimi N, Manavi MS, Faghihkhorasani F, Fakhr SS, Baei FJ, Khorasani FF, et al. Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response. Cancer Metastasis Rev. 2024;43(1):457–79.

Article  CAS  PubMed  Google Scholar 

Dongre A, Weinberg RA. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol. 2019;20(2):69–84.

Article  CAS  PubMed  Google Scholar 

Yang S, Zhang D, Sun Q, Nie H, Zhang Y, Wang X, et al. Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer. Cancer Res. 2024.

Thiery JP, Acloque H, Huang RYJ, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139(5):871–90.

Article  CAS  PubMed  Google Scholar 

Dongre A, Weinberg RA. New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol. 2019;20(2):69–84.

Article  CAS  PubMed  Google Scholar 

Pastushenko I, Blanpain C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29(3):212–26.

Article  CAS  PubMed  Google Scholar 

Nilsson MB, Yang Y, Heeke S, Patel SA, Poteete A, Udagawa H, et al. CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance. Cancer Cell. 2023;41(2):340-55.e6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Broghammer F, Korovina I, Gouda M, Celotti M, van Es J, Lange I, et al. Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome. Mol Cancer. 2024;23(1):39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faheem MM, Seligson ND, Ahmad SM, Rasool RU, Gandhi SG, Bhagat M, et al. Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives. Cell Death Discov. 2020;6:51.

Article  PubMed  PubMed Central  Google Scholar 

Peyre L, Meyer M, Hofman P, Roux J. TRAIL receptor-induced features of epithelial-to-mesenchymal transition increase tumour phenotypic heterogeneity: potential cell survival mechanisms. Br J Cancer. 2021;124(1):91–101.

Article  CAS  PubMed  Google Scholar 

Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3):178–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mladinich M, Ruan D, Chan CH. Tackling cancer stem cells via inhibition of EMT transcription factors. Stem Cells Int. 2016;2016:5285892.

Article  PubMed  PubMed Central  Google Scholar 

Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene. 2010;29(34):4741–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan AQ, Hasan A, Mir SS, Rashid K, Uddin S, Steinhoff M. Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy. Semin Cancer Biol. 2024;100:1–16.

Article  CAS  PubMed  Google Scholar 

Heerboth S, Housman G, Leary M, Longacre M, Byler S, Lapinska K, et al. EMT and tumor metastasis. Clin Transl Med. 2015;4:6.

Article  PubMed  PubMed Central  Google Scholar 

Pietilä M, Ivaska J, Mani SA. Whom to blame for metastasis, the epithelial–mesenchymal transition or the tumor microenvironment? Cancer Lett. 2016;380(1):359–68.

Article  PubMed  Google Scholar 

Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell. 2012;22(6):725–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ocaña OH, Córcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S, et al. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell. 2012;22(6):709–24.

Article  PubMed  Google Scholar 

Terragno M, Vetrova A, Semenov O, Sayan AE, Kriajevska M, Tulchinsky E. Mesenchymal-epithelial transition and AXL inhibitor TP-0903 sensitise triple-negative breast cancer cells to the antimalarial compound, artesunate. Sci Rep. 2024;14(1):425.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horny K, Sproll C, Peiffer L, Furtmann F, Gerhardt P, Gravemeyer J, et al. Mesenchymal-epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression. J Transl Med. 2023;21(1):267.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang L, Kaufmann AM. The significance of cancer stem cells and epithelial-mesenchymal transition in metastasis and anti-cancer therapy. Int J Mol Sci. 2023;24(3):2555.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aiello NM, Kang Y. Context-dependent EMT programs in cancer metastasis. J Exp Med. 2019;216(5):1016–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lüönd F, Sugiyama N, Bill R, Bornes L, Hager C, Tang F, et al. Distinct contributions of partial and full EMT to breast cancer malignancy. Dev Cell. 2021;56(23):3203-21.e11.

Article  PubMed  Google Scholar 

Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, et al. EMT subtype influences epithelial plasticity and mode of cell migration. Dev Cell. 2018;45(6):681-95.e4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dardare J, Witz A, Merlin JL, Bochnakian A, Toussaint P, Gilson P, et al. Epithelial to mesenchymal transition in patients with pancreatic ductal adenocarcinoma: state-of-the-art and therapeutic opportunities. Pharmaceuticals (Basel). 2021;14(8):740.

Article