June CH, O’Connor RS, Kawalekar OU, Ghassemi S, Milone MC. CAR T cell immunotherapy for human cancer. Science. 2018;359(6382):1361–5.
Article CAS PubMed Google Scholar
Wei J, Guo Y, Wang Y, Wu Z, Bo J, Zhang B, et al. Clinical development of CAR T cell therapy in China: 2020 update. Cell Mol Immunol. 2021;18(4):792–804.
Article CAS PubMed Google Scholar
Labanieh L, Mackall CL. CAR immune cells: design principles, resistance and the next generation. Nature. 2023;614(7949):635–48.
Article CAS PubMed Google Scholar
Luo Y, Gao L, Liu J, Yang L, Wang L, Lai X, et al. Donor-derived Anti-CD19 CAR T cells GC007g for relapsed or refractory B-cell acute lymphoblastic leukemia after allogeneic HSCT: a phase 1 trial. EClinicalMedicine. 2024;67:102377.
Sun W, Liang A-B, Huang H, Huang X-J. Strategies to optimize chimeric antigen receptor T-cell therapy in hematologic malignancies: Chinese experience. Haematologica. 2023;108(8):2011–28.
Article CAS PubMed PubMed Central Google Scholar
Mullard A. FDA approves fourth CAR-T cell therapy. Nat Rev Drug Discov. 2021;20(3):166.
Hu Y, Feng J, Gu T, Wang L, Wang Y, Zhou L, et al. CAR T-cell therapies in China: rapid evolution and a bright future. Lancet Haematol. 2022;9(12):e930–41.
Article CAS PubMed Google Scholar
Chavez JC, Bachmeier C, Kharfan-Dabaja MA. CAR T-cell therapy for B-cell lymphomas: clinical trial results of available products. Ther Adv Hematol. 2019;10:2040620719841581.
Article CAS PubMed PubMed Central Google Scholar
Mei H, Hari P, Hu Y. Exercise CALM and make CAR-T therapy work better. Sci Bull (Beijing). 2022;67(19):1925–8.
Fajgenbaum DC, June CH. Cytokine storm. N Engl J Med. 2020;383(23):2255–73.
Article CAS PubMed PubMed Central Google Scholar
Gust J, Hay KA, Hanafi L-A, Li D, Myerson D, Gonzalez-Cuyar LF, et al. Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells. Cancer Discov. 2017;7(12):1404–19.
Article CAS PubMed PubMed Central Google Scholar
Huang Y, Si X, Shao M, Teng X, Xiao G, Huang H. Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells. J Hematol Oncol. 2022;15(1):38.
Article CAS PubMed PubMed Central Google Scholar
Liu Y, An L, Huang R, Xiong J, Yang H, Wang X, et al. Strategies to enhance CAR-T persistence. Biomark Res. 2022;10(1):86.
Article PubMed PubMed Central Google Scholar
Bulliard Y, Andersson BS, Baysal MA, Damiano J, Tsimberidou AM. Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy. J Hematol Oncol. 2023;16(1):108.
Article CAS PubMed PubMed Central Google Scholar
Lai P, Chen X, Wang Y, Wang J, Zhang Y, Geng S, et al. C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction. J Hematol Oncol. 2022;15(1):68.
Article CAS PubMed PubMed Central Google Scholar
Mazinani M, Rahbarizadeh F. CAR-T cell potency: from structural elements to vector backbone components. Biomark Res. 2022;10(1):70.
Article PubMed PubMed Central Google Scholar
Shimabukuro-Vornhagen A, Böll B, Schellongowski P, Valade S, Metaxa V, Azoulay E, et al. Critical care management of chimeric antigen receptor T-cell therapy recipients. CA Cancer J Clin. 2022;72(1):78–93.
Westin JR, Oluwole OO, Kersten MJ, Miklos DB, Perales M-A, Ghobadi A, et al. Survival with Axicabtagene Ciloleucel in large B-Cell lymphoma. N Engl J Med. 2023;389(2):148–57.
Article CAS PubMed Google Scholar
Locke FL, Miklos DB, Jacobson CA, Perales M-A, Kersten M-J, Oluwole OO, et al. Axicabtagene Ciloleucel as Second-Line therapy for large B-Cell lymphoma. N Engl J Med. 2022;386(7):640–54.
Article CAS PubMed Google Scholar
Ajina A, Maher J. Strategies to address chimeric Antigen receptor Tonic Signaling. Mol Cancer Ther. 2018;17(9):1795–815.
Article CAS PubMed PubMed Central Google Scholar
Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, et al. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med. 2015;21(6):581–90.
Article CAS PubMed PubMed Central Google Scholar
Chen J, Qiu S, Li W, Wang K, Zhang Y, Yang H, et al. Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness. Cell Res. 2023;33(5):341–54.
Article CAS PubMed PubMed Central Google Scholar
Teng F, Cui T, Zhou L, Gao Q, Zhou Q, Li W. Programmable synthetic receptors: the next-generation of cell and gene therapies. Signal Transduct Target Ther. 2024;9(1):7.
Article CAS PubMed PubMed Central Google Scholar
Di Stasi A, Tey S-K, Dotti G, Fujita Y, Kennedy-Nasser A, Martinez C, et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med. 2011;365(18):1673–83.
Article PubMed PubMed Central Google Scholar
Diaconu I, Ballard B, Zhang M, Chen Y, West J, Dotti G, et al. Inducible Caspase-9 selectively modulates the toxicities of CD19-Specific chimeric Antigen receptor-modified T cells. Mol Ther. 2017;25(3):580–92.
Article CAS PubMed PubMed Central Google Scholar
Mestermann K, Giavridis T, Weber J, Rydzek J, Frenz S, Nerreter T et al. The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells. Sci Transl Med. 2019; 11(499).
Cao W, Geng ZZ, Wang N, Pan Q, Guo S, Xu S, et al. A reversible Chemogenetic switch for Chimeric Antigen Receptor T Cells. Angew Chem Int Ed Engl. 2022;61(10):e202109550.
Article CAS PubMed Google Scholar
Wu Y, Liu Y, Huang Z, Wang X, Jin Z, Li J, et al. Control of the activity of CAR-T cells within tumours via focused ultrasound. Nat Biomed Eng. 2021;5(11):1336–47.
Article CAS PubMed PubMed Central Google Scholar
Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B et al. Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Cancer Cell. 2022; 40(12).
Huang Z, Wu Y, Allen ME, Pan Y, Kyriakakis P, Lu S, et al. Engineering light-controllable CAR T cells for cancer immunotherapy. Sci Adv. 2020;6(8):eaay9209.
Article CAS PubMed PubMed Central Google Scholar
Li H-S, Wong NM, Tague E, Ngo JT, Khalil AS, Wong WW. High-performance multiplex drug-gated CAR circuits. Cancer Cell. 2022; 40(11).
Qi J, Tsuji K, Hymel D, Burke TR, Hudecek M, Rader C, et al. Chemically programmable and switchable CAR-T therapy. Angew Chem Int Ed Engl. 2020;59(29):12178–85.
留言 (0)