DNA fragmentation factor 40-based therapeutic approaches for cancer: a review article

Sánchez-Tilló E, Liu Y, de Barrios O, Siles L, Fanlo L, Cuatrecasas M, et al. EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness. Cell Mol Life Sci. 2012;69:3429–56.

Article  PubMed  PubMed Central  Google Scholar 

Kulbay M, Paimboeuf A, Ozdemir D, Bernier J. Review of cancer cell resistance mechanisms to apoptosis and actual targeted therapies. J Cell Biochem. 2022;123(11):1736–61.

Article  PubMed  Google Scholar 

Widłak P. The DFF40/CAD endonuclease and its role in apoptosis. Acta Biochim Pol. 2000;47(4):1037–44.

Article  PubMed  Google Scholar 

Bock FJ, Tait SW. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. 2020;21(2):85–100.

Article  PubMed  Google Scholar 

Wyllie AH. Cell death. In: Cytology and cell physiology. Elsevier; 1987. p. 755–85.

Google Scholar 

Nagata S. Apoptosis by death factor. Cell. 1997;88(3):355–65.

Article  PubMed  Google Scholar 

Evan G, Littlewood T. A matter of life and cell death. Science. 1998;281(5381):1317–22.

Article  PubMed  Google Scholar 

Zhivotovsky B, Wade D, Nicotera P, Orrenius S. Role of nucleases in apoptosis. Int Arch Allergy Immunol. 1994;105(4):333–8.

Article  PubMed  Google Scholar 

Montague J, Cidlowski J. Cellular catabolism in apoptosis: DNA degradation and endonuclease activation. Experientia. 1996;52(10–11):957–62.

Article  PubMed  Google Scholar 

Khodarev IA, Sokolova ATM, Vaughan N. Review mechanisms of induction of apoptotic DNA fragmentation. Int J Radiat Biol. 1998;73(5):455–67.

Article  PubMed  Google Scholar 

Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 1997;89(2):175–84.

Article  PubMed  Google Scholar 

Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 1998;391(6662):43–50.

Article  PubMed  Google Scholar 

Halenbeck R, MacDonald H, Roulston A, Chen TT, Conroy L, Williams LT. CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45. Curr Biol. 1998;8(9):S1.

Article  Google Scholar 

Liu X, Li P, Widlak P, Zou H, Luo X, Garrard WT, Wang X. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci. 1998;95(15):8461–6.

Article  PubMed  PubMed Central  Google Scholar 

Gu J, Dong R-P, Zhang C, McLaughlin DF, Wu MX, Schlossman SF. Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40. J Biol Chem. 1999;274(30):20759–62.

Article  PubMed  Google Scholar 

Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G. Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Cell. 1999;99(7):747–55.

Article  PubMed  Google Scholar 

Otomo T, Sakahira H, Uegaki K, Nagata S, Yamazaki T. Structure of the heterodimeric complex between CAD domains of CAD and ICAD. Nat Struct Biol. 2000;7(8):658–62.

Article  PubMed  Google Scholar 

Liu X, Zou H, Widlak P, Garrard W, Wang X. Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease): oligomerization and direct interaction with histone H1. J Biol Chem. 1999;274(20):13836–40.

Article  PubMed  Google Scholar 

Widlak P, Li P, Wang X, Garrard WT. Cleavage preferences of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease) on naked DNA and chromatin substrates. J Biol Chem. 2000;275(11):8226–32.

Article  PubMed  Google Scholar 

Sakahira H, Enari M, Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature. 1998;391(6662):96–9.

Article  PubMed  Google Scholar 

Charrier L, Jarry A, Toquet C, Bou-Hanna C, Chedorge M, Denis M, et al. Growth phase-dependent expression of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer cells. Can Res. 2002;62(7):2169–74.

Google Scholar 

Hsieh S, Liaw S, Lee S, Hsieh P, Lin K, Chu C, Liaw Y. Aberrant caspase-activated DNase (CAD) transcripts in human hepatoma cells. Br J Cancer. 2003;88(2):210–6.

Article  PubMed  PubMed Central  Google Scholar 

Hsieh S-Y, Chen W-Y, Yeh T-S, Sheen I, Huang S-F. High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma. Oncogene. 2005;24(43):6584–9.

Article  PubMed  Google Scholar 

Brustmann H. Poly (ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. Pathol—Res Practice. 2007;203(2):65–72.

Article  Google Scholar 

Banas T, Pitynski K, Okon K, Czerw A. DNA fragmentation factors 40 and 45 (DFF40/DFF45) and B-cell lymphoma 2 (Bcl-2) protein are underexpressed in uterine leiomyosarcomas and may predict survival. OncoTargets Therap. 2017;10:4579–89.

Article  Google Scholar 

Banas T, Pitynski K, Okon K, Winiarska A. Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression. BMC Cancer. 2018;18:1–11.

Article  Google Scholar 

Mukae N, Enari M, Sakahira H, Fukuda Y, Inazawa J, Toh H, Nagata S. Molecular cloning and characterization of human caspase-activated DNase. Proc Natl Acad Sci. 1998;95(16):9123–8.

Article  PubMed  PubMed Central  Google Scholar 

Yamaguchi K, Uzzo R, Dulin N, Finke JH, Kolenko V. Renal carcinoma cells undergo apoptosis without oligonucleosomal DNA fragmentation. Biochem Biophys Res Commun. 2004;318(3):710–3.

Article  PubMed  Google Scholar 

Kulbay M, Johnson B, Fiola S, Diaz RJ, Bernier J. DFF40 deficiency in cancerous T cells is implicated in chemotherapy drug sensitivity and resistance through the regulation of the apoptotic pathway. Biochem Pharmacol. 2021;194:114801.

Article  PubMed  Google Scholar 

Sanchez-Osuna M, Martinez-Escardo L, Granados-Colomina C, Martinez-Soler F, Pascual-Guiral S, Iglesias-Guimarais V, et al. An intrinsic DFF40/CAD endonuclease deficiency impairs oligonucleosomal DNA hydrolysis during caspase-dependent cell death: a common trait in human glioblastoma cells. Neuro Oncol. 2016;18(7):950–61.

Article  PubMed  PubMed Central  Google Scholar 

Bagheri F, Safarian S, Eslaminejad MB, Sheibani N. Stable overexpression of DNA fragmentation factor in T-47D cells: sensitization of breast cancer cells to apoptosis in response to acetazolamide and sulfabenzamide. Mol Biol Rep. 2014;41:7387–94.

Article  PubMed  PubMed Central  Google Scholar 

Ben-Yehudah A, Aqeilan R, Robashkevich D, Lorberboum-Galski H. Using apoptosis for targeted cancer therapy by a new gonadotropin releasing hormone-DNA fragmentation factor 40 chimeric protein. Clin Cancer Res. 2003;9(3):1179–90.

PubMed  Google Scholar 

Barazesh M, Mohammadi S, Jalili S, Kavousipour S, Faraji SN, Mokarram P, Pirhadi S. Design and characterization of a recombinant immunotoxin for targeted therapy of breast cancer cells: in vitro and in silico analyses. Life Sci. 2021;265:118866.

Article  PubMed  Google Scholar 

Lu D, Guo Y, Hu Y, Wang M, Li C, Gangrade A, et al. Fusion of apoptosis-related protein Cytochrome C with anti-HER-2 single-chain antibody targets the suppression of HER-2+ breast cancer. J Cell Mol Med. 2021;25(22):10638–49.

Article  PubMed  PubMed Central  Google Scholar 

Mathew M, Zaineb K, Verma RS. GM-CSF-DFF40: a novel humanized immunotoxin induces apoptosis in acute myeloid leukemia cells. Apoptosis. 2013;18:882–95.

Article  PubMed  Google Scholar 

Amrollahi-Nia R, Akbari V, Shafiee F. DFF40-iRGD, a novel chimeric protein with efficient cytotoxic and apoptotic effects against triple-negative breast cancer cells. Biotech Lett. 2021;43:1967–76.

Article  Google Scholar 

Tan L, Bai L, Wang L, He L, Li G, Du W, et al. Antifungal activity of spider venom-derived peptide lycosin-I against Candida tropicalis. Microbiol Res. 2018;216:120–8.

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