Robison, L. L. & Hudson, M. M. Survivors of childhood and adolescent cancer: life-long risks and responsibilities. Nat. Rev. Cancer 14, 61–70 (2014).

Article  CAS  PubMed  Google Scholar 

Gibson, T. M. et al. Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970–99: a report from the Childhood Cancer Survivor Study cohort. Lancet Oncol. 19, 1590–1601 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Ehrhardt, M. J. et al. Improving quality and quantity of life for childhood cancer survivors globally in the twenty-first century. Nat. Rev. Clin. Oncol. 20, 678–696 (2023).

Article  PubMed  Google Scholar 

Bhakta, N. et al. The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE). Lancet 390, 2569–2582 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Ehrhardt, M. J. et al. Association of modifiable health conditions and social determinants of health with late mortality in survivors of childhood cancer. JAMA Netw. Open. 6, e2255395 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Dixon, S. B. et al. Specific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort. Lancet 401, 1447–1457 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Lipshultz, S. E. et al. Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. Circulation 128, 1927–1995 (2013).

Article  PubMed  Google Scholar 

Armenian, S. H. et al. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 16, e123–e136 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Mulrooney, D. A. et al. Cardiac outcomes in adult survivors of childhood cancer exposed to cardiotoxic therapy: a cross-sectional study. Ann. Intern. Med. 164, 93–101 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Moskowitz, C. S. et al. Breast cancer after chest radiation therapy for childhood cancer. J. Clin. Oncol. 32, 2217–2223 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Ehrhardt, M. J. et al. Subsequent breast cancer in female childhood cancer survivors in the St Jude Lifetime Cohort Study (SJLIFE). J. Clin. Oncol. 37, 1647–1656 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, Y. et al. Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer. Nat. Med. 29, 2268–2277 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henderson, T. O. et al. Breast cancer risk in childhood cancer survivors without a history of chest radiotherapy: a report from the Childhood Cancer Survivor Study. J. Clin. Oncol. 34, 910–918 (2016).

Article  CAS  PubMed  Google Scholar 

Veiga, L. H. et al. Association of breast cancer risk after childhood cancer with radiation dose to the breast and anthracycline use: a report from the Childhood Cancer Survivor Study. JAMA Pediatr. 173, 1171–1179 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Bashore, L. & Hobbie, W. Emerging and ongoing survivorship challenges among childhood cancer survivors and providing risk-based focused follow-up care. Semin. Oncol. Nurs. 37, 151163 (2021).

Article  PubMed  Google Scholar 

Forster, V. J. What cancer survivors can teach cancer researchers. Nat. Rev. Cancer 22, 431–432 (2022).

Article  CAS  PubMed  Google Scholar 

Qin, N. et al. Pathogenic germline mutations in DNA repair genes in combination with cancer treatment exposures and risk of subsequent neoplasms among long-term survivors of childhood cancer. J. Clin. Oncol. 38, 2728–2740 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song, N. et al. Persistent variations of blood DNA methylation associated with treatment exposures and risk for cardiometabolic outcomes in long-term survivors of childhood cancer in the St. Jude Lifetime Cohort. Genome Med. 13, 53 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hagiwara, K. et al. Dynamics of age- versus therapy-related clonal hematopoiesis in long-term survivors of pediatric cancer. Cancer Discov. 13, 844–857 (2023). This work is the first large-scale study of CH in long-term survivors of childhood cancer.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morton, L. M. et al. Genome-wide association study to identify susceptibility loci that modify radiation-related risk for breast cancer after childhood cancer. J. Natl Cancer Inst. 109, djx058 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Wang, Z. et al. Genetic risk for subsequent neoplasms among Long-term survivors of childhood cancer. J. Clin. Oncol. 36, 2078–2087 (2018). This work presents the first WGS dataset on a childhood cancer survivorship cohort, with the data used in many follow-up genetic studies, and presents the first comprehensive analysis of the risk conferred by cancer predisposing variants, stratified by exposure to radiation, to subsequent neoplasms.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim, J. et al. Frequency of pathogenic germline variants in cancer-susceptibility genes in the Childhood Cancer Survivor Study. JNCI Cancer Spectr. 5, pkab007 (2021). This work presents a large-scale WES dataset generated with the largest cohort of survivors of childhood cancer in North America, and has been used as a data resource in many of the subsequent studies.

Article  PubMed  PubMed Central  Google Scholar 

Hudson, M. M. et al. Clinical ascertainment of health outcomes among adults treated for childhood cancer. JAMA 309, 2371–2381 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robison, L. L. et al. The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. J. Clin. Oncol. 27, 2308–2318 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Waespe, N. et al. Cohort-based association study of germline genetic variants with acute and chronic health complications of childhood cancer and its treatment: Genetic Risks for Childhood Cancer Complications Switzerland (GECCOS) study protocol. BMJ Open 12, e052131 (2022).

Article  PubMed  PubMed Central  Google Scholar 

McLeod, C. et al. St. Jude Cloud: a pediatric cancer genomic data-sharing ecosystem. Cancer Discov. 11, 1082–1099 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flores-Toro, J. A. et al. The Childhood Cancer Data Initiative: using the power of data to learn from and improve outcomes for every child and young adult with pediatric cancer. J. Clin. Oncol. 41, 4045–4053 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Im, C. et al. Generalizability of “GWAS hits” in clinical populations: lessons from childhood cancer survivors. Am. J. Hum. Genet. 107, 636–653 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goodenough, C. G. et al. Association between CEP72 genotype and persistent neuropathy in survivors of childhood acute lymphoblastic leukemia. Leukemia 36, 1160–1163 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Dorp, W. et al. Genetic variation may modify ovarian reserve in female childhood cancer survivors. Hum. Reprod. 28, 1069–1076 (2013).

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