Schwartzberg, L., Kim, E. S., Liu, D. & Schrag, D. Precision oncology: who, how, what, when, and when not? Am. Soc. Clin. Oncol. Educ. Book. 37, 160–169 (2017).
Flaherty, K. T. et al. The Molecular Analysis for Therapy Choice (NCI-MATCH) trial: lessons for genomic trial design. J. Natl Cancer Inst. 112, 1021–1029 (2020). This paper outlines a landmark precision oncology trial.
Article PubMed PubMed Central Google Scholar
Letai, A., Bhola, P. & Welm, A. L. Functional precision oncology: testing tumors with drugs to identify vulnerabilities and novel combinations. Cancer Cell 40, 26–35 (2022).
Letai, A. Functional precision cancer medicine—moving beyond pure genomics. Nat. Med. 23, 1028–1035 (2017).
van Renterghem, A. W. J., van de Haar, J. & Voest, E. E. Functional precision oncology using patient-derived assays: bridging genotype and phenotype. Nat. Rev. Clin. Oncol. 20, 305–317 (2023).
Bose, S. et al. A path to translation: how 3D patient tumor avatars enable next generation precision oncology. Cancer Cell 40, 1448–1453 (2022).
Article PubMed PubMed Central Google Scholar
Woo, X. Y. et al. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts. Nat. Genet. 53, 86–99 (2021). This paper demonstrates genomic fidelity between patient tumours and PDXs for a range of cancer types.
Article PubMed PubMed Central Google Scholar
Liu, Y. et al. Patient-derived xenograft models in cancer therapy: technologies and applications. Signal Transduct. Target. Ther. 8, 160 (2023).
Article PubMed PubMed Central Google Scholar
Sun, H. et al. Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment. Nat. Commun. 12, 5086 (2021). This paper investigates genomic and pharmacogenomic relationships between human tumours and pan-cancer PDX models.
Article PubMed PubMed Central Google Scholar
Byrne, A. T. et al. Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nat. Rev. Cancer 17, 254–268 (2017).
Zanella, E. R., Grassi, E. & Trusolino, L. Towards precision oncology with patient-derived xenografts. Nat. Rev. Clin. Oncol. 19, 719–732 (2022).
Lynch, I. T. et al. Cancer “avatars”: patient-derived xenograft growth correlation with postoperative recurrence and survival in pancreaticobiliary cancer. J. Am. Coll. Surg. 237, 483–500 (2023).
Article PubMed PubMed Central Google Scholar
Castillo-Ecija, H. et al. Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas. J. Pathol. Clin. Res. 7, 338–349 (2021).
Article PubMed PubMed Central Google Scholar
Chen, Q. et al. Patient-derived xenograft model engraftment predicts poor prognosis after surgery in patients with pancreatic cancer. Pancreatology 20, 485–492 (2020).
Vaklavas, C. et al. TOWARDS study: PDX engraftment predicts poor survival in newly diagnosed triple negative breast cancer patients. JCO Precis. Oncon. 8, e2300724 (2024). This paper demonstrates in a prospective clinical trial that PDX models can be used to assess recurrence risk.
Hidalgo, M. et al. A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer. Mol. Cancer Ther. 10, 1311–1316 (2011).
Article PubMed PubMed Central Google Scholar
Astone, M., Dankert, E. N., Alam, S. K. & Hoeppner, L. H. Fishing for cures: the alLURE of using zebrafish to develop precision oncology therapies. npj Precis. Oncol. 1, 39 (2017).
Article PubMed PubMed Central Google Scholar
Moy, R. H. et al. Defining and targeting esophagogastric cancer genomic subsets with patient-derived xenografts. JCO Precis. Oncol. 6, e2100242 (2022).
Article PubMed PubMed Central Google Scholar
Guan, Z. et al. Individualized drug screening based on next generation sequencing and patient derived xenograft model for pancreatic cancer with bone metastasis. Mol. Med. Rep. 16, 4784–4790 (2017).
Article PubMed PubMed Central Google Scholar
Nicolle, R. et al. Pancreatic adenocarcinoma therapeutic targets revealed by tumor–stroma cross-talk analyses in patient-derived xenografts. Cell Rep. 21, 2458–2470 (2017).
Article PubMed PubMed Central Google Scholar
Conage-Pough, J. E. et al. WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models. Neurooncol. Adv. 5, vdad066 (2023).
PubMed PubMed Central Google Scholar
Pandya, P. H. et al. Integrative multi-OMICs identifies therapeutic response biomarkers and confirms fidelity of clinically annotated, serially passaged patient-derived xenografts established from primary and metastatic pediatric and AYA solid tumors. Cancers (Basel) 15, 259 (2022).
Hemming, M. L. et al. Preclinical modeling of leiomyosarcoma identifies susceptibility to transcriptional CDK inhibitors through antagonism of E2F-driven oncogenic gene expression. Clin. Cancer Res. 28, 2397–2408 (2022).
Article PubMed PubMed Central Google Scholar
Hsu, C. L. et al. Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor palbociclib as a novel candidate drug for nasopharyngeal carcinoma. J. Exp. Clin. Cancer Res. 37, 233 (2018).
Article PubMed PubMed Central Google Scholar
Karamboulas, C. et al. Patient-derived xenografts for prognostication and personalized treatment for head and neck squamous cell carcinoma. Cell Rep. 25, 1318–1331.e4 (2018).
Punzi, S. et al. Development of personalized therapeutic strategies by targeting actionable vulnerabilities in metastatic and chemotherapy-resistant breast cancer PDXs. Cells 8, 605 (2019).
Article PubMed PubMed Central Google Scholar
Kohale, I. N. et al. Identification of Src family kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer. Cancers (Basel) 14, 4220 (2022).
Saridogan, T. et al. Efficacy of futibatinib, an irreversible fibroblast growth factor receptor inhibitor, in FGFR-altered breast cancer. Sci. Rep. 13, 20223 (2023).
Article PubMed PubMed Central Google Scholar
Kim, M. et al. Efficacy of the MDM2 inhibitor SAR405838 in glioblastoma is limited by poor distribution across the blood–brain barrier. Mol. Cancer Ther. 17, 1893–1901 (2018).
Article PubMed PubMed Central Google Scholar
Fiore, D. et al. A novel JAK1 mutant breast implant-associated anaplastic large cell lymphoma patient-derived xenograft fostering pre-clinical discoveries. Cancers (Basel) 12, 1603 (2020).
De Coninck, S. et al. Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma. Haematologica 109, 1373–1384 (2024).
Paolino, J. et al. Integration of genomic sequencing drives therapeutic targeting of PDGFRA in T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. Clin. Cancer Res. 29, 4613–4626 (2023).
Article PubMed PubMed Central Google Scholar
Rivera, M. et al. Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine. Neoplasia 23, 21–35 (2021).
Krausert, S. et al. Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma. Neurooncol. Adv. 4, vdac026 (2022).
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