A case series and review of stereotactic body radiation therapy for contiguous multilevel spine metastases

Fomchenko EI, Bayley JC, Alvarez-Breckenridge C, Rhines LD, Tatsui CE (2022) Spinal metastases and the Evolving role of molecular targeted therapy, chemotherapy, and Immunotherapy. Neurospine Dec 19(4):978–993. https://doi.org/10.14245/ns.2244290.145

Article  Google Scholar 

Klimo P Jr., Schmidt MH (2004) Surgical management of spinal metastases. Oncologist 9(2):188–196. https://doi.org/10.1634/theoncologist.9-2-188

Article  PubMed  Google Scholar 

Sahgal A, Myrehaug SD, Siva S et al (2021) Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial. Lancet Oncol Jul 22(7):1023–1033. https://doi.org/10.1016/S1470-2045(21)00196-0

Article  Google Scholar 

Zeng KL, Myrehaug S, Soliman H et al (2022) Mature local control and reirradiation rates comparing spine stereotactic body Radiation Therapy with Conventional Palliative External Beam Radiation Therapy. Int J Radiat Oncol Biol Phys Oct 1(2):293–300. https://doi.org/10.1016/j.ijrobp.2022.05.043

Article  Google Scholar 

Singh R, Lehrer EJ, Dahshan B et al (2020) Single fraction radiosurgery, fractionated radiosurgery, and conventional radiotherapy for spinal oligometastasis (SAFFRON): a systematic review and meta-analysis. Radiother Oncol May 146:76–89. https://doi.org/10.1016/j.radonc.2020.01.030

Article  Google Scholar 

Ryu S, Deshmukh S, Timmerman RD et al (2023) Stereotactic radiosurgery vs conventional radiotherapy for localized vertebral metastases of the spine: phase 3 results of NRG Oncology/RTOG 0631 Randomized Clinical Trial. JAMA Oncol Jun 1(6):800–807. https://doi.org/10.1001/jamaoncol.2023.0356

Article  Google Scholar 

Lee CC, Soon YY, Cheo T, Vellayappan B, Tey J (2022) Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: a systematic review and meta-analysis of randomized trials. Crit Rev Oncol Hematol Oct 178:103775. https://doi.org/10.1016/j.critrevonc.2022.103775

Article  Google Scholar 

Tree AC, Ostler P, van der Voet H et al (2022) Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial. Lancet Oncol Oct 23(10):1308–1320. https://doi.org/10.1016/S1470-2045(22)00517-4

Article  Google Scholar 

Nyman J, Hallqvist A, Lund JA et al (2016) SPACE - A randomized study of SBRT vs conventional fractionated radiotherapy in medically inoperable stage I NSCLC. Radiother Oncol Oct 121(1):1–8. https://doi.org/10.1016/j.radonc.2016.08.015

Article  Google Scholar 

Gerszten PC, Burton SA, Ozhasoglu C, Welch WC (1976) Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine (Phila Pa Jan 15 2007;32(2):193-9. https://doi.org/10.1097/01.brs.0000251863.76595.a2

Wang XS, Rhines LD, Shiu AS et al (2012) Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial. Lancet Oncol Apr 13(4):395–402. https://doi.org/10.1016/S1470-2045(11)70384-9

Article  Google Scholar 

Mahadevan A, Floyd S, Wong E, Jeyapalan S, Groff M, Kasper E (2011) Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases. Int J Radiat Oncol Biol Phys Dec 1(5):1500–1505. https://doi.org/10.1016/j.ijrobp.2010.08.012

Article  Google Scholar 

Sohn S, Chung CK, Sohn MJ et al (2014) Stereotactic radiosurgery compared with external radiation therapy as a primary treatment in spine metastasis from renal cell carcinoma: a multicenter, matched-pair study. J Neurooncol Aug 119(1):121–128. https://doi.org/10.1007/s11060-014-1455-9

Article  Google Scholar 

Garg AK, Shiu AS, Yang J et al (2012) Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases. Cancer Oct 15(20):5069–5077. https://doi.org/10.1002/cncr.27530

Article  Google Scholar 

Thibault I, Campbell M, Tseng CL et al (2015) Salvage stereotactic body Radiotherapy (SBRT) following In-Field failure of initial SBRT for spinal metastases. Int J Radiat Oncol Biol Phys Oct 1(2):353–360. https://doi.org/10.1016/j.ijrobp.2015.03.029

Article  Google Scholar 

Myrehaug S, Sahgal A, Hayashi M et al (2017) Reirradiation spine stereotactic body radiation therapy for spinal metastases: systematic review. J Neurosurg Spine Oct 27(4):428–435. https://doi.org/10.3171/2017.2.SPINE16976

Article  Google Scholar 

Moore-Palhares D, Sahgal A, Zeng KL et al (2023) 30 gy in 4 stereotactic body radiotherapy fractions for Complex spinal metastases: mature outcomes supporting this Novel Regimen. Neurosurg Oct 1(4):813–823. https://doi.org/10.1227/neu.0000000000002498

Article  Google Scholar 

Beeler WH, Speth KA, Broderick MT et al (2020) Local Control and toxicity of Multilevel Spine stereotactic body Radiotherapy. Neurosurg Feb 1(2):E164–E172. https://doi.org/10.1093/neuros/nyz348

Article  Google Scholar 

Kowalchuk RO, Waters MR, Richardson KM et al (2020) Stereotactic radiosurgery for the treatment of bulky spine metastases. J Neurooncol Jun 148(2):381–388. https://doi.org/10.1007/s11060-020-03534-4

Article  Google Scholar 

Dibs K, Blakaj DM, Prasad RN et al (2022) Spine stereotactic body radiotherapy to three or more contiguous vertebral levels. Front Oncol 12:912804. https://doi.org/10.3389/fonc.2022.912804

Article  PubMed  PubMed Central  Google Scholar 

Bilsky MH, Laufer I, Fourney DR et al (2010) Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine Sep 13(3):324–328. https://doi.org/10.3171/2010.3.SPINE09459

Article  Google Scholar 

Hurley P, Azzopardi C, Botchu R, Grainger M, Gardner A (2021) Can MRI be used as a safe and expedient option for calculating spinal instability neoplastic score for patients with metastatic spinal cord compression? Bone Joint J May 103–B(5):971–975. https://doi.org/10.1302/0301-620X.103B5.BJJ-2020-1823.R1

Article  Google Scholar 

van Leeuwen CM, Oei AL, Crezee J et al (2018) The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies. Radiat Oncol May 16(1):96. https://doi.org/10.1186/s13014-018-1040-z

Article  Google Scholar 

Lee SH, Lee KC, Choi J et al (2015) Clinical applicability of biologically effective dose calculation for spinal cord in fractionated spine stereotactic body radiation therapy. Radiol Oncol Jun 49(2):185–191. https://doi.org/10.1515/raon-2015-0008

Article  Google Scholar 

Gerszten PC, Burton SA, Ozhasoglu C (2007) CyberKnife radiosurgery for spinal neoplasms. Prog Neurol Surg 20:340–358. https://doi.org/10.1159/000100177

Article  PubMed  Google Scholar 

Ling DC, Flickinger JC, Burton SA et al (2018) Long-term outcomes after stereotactic radiosurgery for spine metastases: Radiation dose-response for late toxicity. Int J Radiat Oncol Biol Phys Jul 1(3):602–609. https://doi.org/10.1016/j.ijrobp.2018.02.035

Article  Google Scholar 

Gerszten PC, Monaco EA 3rd, Quader M et al (2010) Setup accuracy of spine radiosurgery using cone beam computed tomography image guidance in patients with spinal implants. J Neurosurg Spine Apr 12(4):413–420. https://doi.org/10.3171/2009.10.SPINE09249

Article  Google Scholar 

Cox BW, Spratt DE, Lovelock M et al (2012) International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys Aug 1(5):e597–605. https://doi.org/10.1016/j.ijrobp.2012.03.009

Article  Google Scholar 

Redmond KJ, Lo SS, Soltys SG et al (2017) Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey. J Neurosurg Spine Mar 26(3):299–306. https://doi.org/10.3171/2016.8.SPINE16121

Article  Google Scholar 

Thibault I, Chang EL, Sheehan J et al (2015) Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group. Lancet Oncol Dec 16(16):e595–603. https://doi.org/10.1016/S1470-2045(15)00166-7

Article  Google Scholar 

U.S. Department of Health and Human Services (2017) Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. U.S. Department of Health and Human Services B, MD

Cox BW, Jackson A, Hunt M, Bilsky M, Yamada Y (2012) Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys Aug 1(5):e661–e667. https://doi.org/10.1016/j.ijrobp.2012.01.080

Article  Google Scholar 

Taori S, Adida S, Tang A et al (2024) Stereotactic radiosurgery for patients with spinal metastases from thyroid Cancer: a 20-Year experience. World Neurosurg Feb 25. https://doi.org/10.1016/j.wneu.2024.02.102

Taori S, Adida S, Tang A et al (2024) The role of spine stereotactic radiosurgery for patients with breast cancer metastases. J Neurooncol Feb 14. https://doi.org/10.1007/s11060-024-04599-1

Adida S, Kann MR, Taori S et al (2024) Safety and efficacy of balloon-assisted Kyphoplasty followed by stereotactic body Radiation Therapy for pathological fractures. Neurosurg Sep 16. https://doi.org/10.1227/neu.0000000000003182

Adida S, Taori S, Donohue JK et al (2024) Stereotactic radiosurgery for patients with spinal metastases from prostate cancer. J Neurooncol Sep 24. https://doi.org/10.1007/s11060-024-04821-0

Sasagawa T, Kawahara N, Murakami H et al (2011) The route of metastatic vertebral tumors extending to the adjacent vertebral body: a histological study. J Orthop Sci Mar 16(2):203–211. https://doi.org/10.1007/s00776-011-0031-9

Article  Google Scholar 

Algra PR, Heimans JJ, Valk J, Nauta JJ, Lachniet M, Van Kooten B (1992) Do metastases in vertebrae begin in the body or the pedicles? Imaging study in 45 patients. AJR Am J Roentgenol Jun 158(6):1275–1279. https://doi.org/10.2214/ajr.158.6.1590123

Article  Google Scholar 

Asdourian PL, Weidenbaum M, DeWald RL, Hammerberg KW, Ramsey RG (1990) The pattern of vertebral involvement in metastatic vertebral breast cancer. Clin Orthop Relat Res Jan;(250):164–170

Fujita T, Ueda Y, Kawahara N, Baba H, Tomita K (1976) Local spread of metastatic vertebral tumors. A histologic study. Spine (Phila Pa Aug 15 1997;22(16):1905-12. https://doi.org/10.1097/00007632-199708150-00020

Arguello F, Baggs RB, Duerst RE, Johnstone L, McQueen K, Frantz CN (1990) Pathogenesis of vertebral metastasis and epidural spinal cord compression. Cancer. Jan 1.;65(1):98–106.

Laufer I, Rubin DG, Lis E et al (2013) The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist Jun 18(6):744–751. https://doi.org/10.1634/theoncologist.2012-0293

Article  Google Scholar 

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