Stupp R, Mason WP, van den Bent MJ et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. 352(10):987–996

Weller M, Le Rhun E, Van den Bent M, Chang SM, Cloughesy TF, Goldbrunner R, Hong YK, Jalali R, Jenkinson MD, Minniti G, Nagane M, Razis E, Roth P, Rudà R, Tabatabai G, Wen PY, Short SC, Preusser M (2023) Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults. Neuro Oncol 25(7):1200–1224. https://doi.org/10.1093/neuonc/noad038

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell. 144(5):646– 74. https://doi.org/10.1016/j.cell.2011.02.013

Zhang J, Yao YH, Li BG, Yang Q, Zhang PY, Wang HT (2015) Prognostic value of pretreatment serum lactate dehydrogenase level in patients with solid tumors: a systematic review and meta-analysis. Sci Rep 5:9800. https://doi.org/10.1038/srep09800

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petrelli F, Ardito R, Merelli B, Lonati V, Cabiddu M, Seghezzi S, Barni S, Ghidini A (2019) Prognostic and predictive role of elevated lactate dehydrogenase in patients with melanoma treated with immunotherapy and BRAF inhibitors: a systematic review and meta-analysis. Melanoma Res. 29(1):1–12. https://doi.org/10.1097/CMR.0000000000000520

Wu W, Miao L, Zhao L, Zhu Y, Mao J, Cai Z, Ji Y, Wang L, Wang Y, Jia T (2024) Prognostic value of lactate dehydrogenase, serum albumin and the lactate dehydrogenase/albumin ratio in patients with diffuse large B-cell lymphoma. Hematology 29(1):2293514. https://doi.org/10.1080/16078454.2023.2293514

Article  PubMed  Google Scholar 

Wu XB, Hou SL, Liu H (2021) Systemic immune inflammation index, ratio of lymphocytes to monocytes, lactate dehydrogenase and prognosis of diffuse large B-cell lymphoma patients. World J Clin Cases 9(32):9825–9834. https://doi.org/10.12998/wjcc.v9.i32.9825

Article  PubMed  PubMed Central  Google Scholar 

Tjokrowidjaja A, Lord SJ, John T, Lewis CR, Kok PS, Marschner IC, Lee CK (2022) Pre- and on-treatment lactate dehydrogenase as a prognostic and predictive biomarker in advanced non-small cell lung cancer. Cancer 128(8):1574–1583. https://doi.org/10.1002/cncr.34113

Article  CAS  PubMed  Google Scholar 

Zhang Z, Li Y, Yan X, Song Q, Wang G, Hu Y, Jiao S, Wang J (2019) Pretreatment lactate dehydrogenase may predict outcome of advanced non small-cell lung cancer patients treated with immune checkpoint inhibitors: a meta-analysis. Cancer Med 8(4):1467–1473. https://doi.org/10.1002/cam4.2024

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagarajan A, Malvi P, Wajapeyee N (2016) Oncogene-directed alterations in cancer cell metabolism. Trends Cancer 2(7):365–377. https://doi.org/10.1016/j.trecan.2016.06.002

Article  PubMed  PubMed Central  Google Scholar 

Feng Y, Xiong Y, Qiao T, Li X, Jia L, Han Y (2018) Lactate dehydrogenase A: a key player in carcinogenesis and potential target in cancer therapy. Cancer Med 7(12):6124–6136. https://doi.org/10.1002/cam4.1820

Article  PubMed  PubMed Central  Google Scholar 

Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O’Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN (2010) Cancer Genome Atlas Research Network. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17(1):98–110. https://doi.org/10.1016/j.ccr.2009.12.020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sareen H, Ma Y, Becker TM, Roberts TL, de Souza P, Powter B (2022) Molecular biomarkers in Glioblastoma: a systematic review and Meta-analysis. Int J Mol Sci 23(16):8835. https://doi.org/10.3390/ijms23168835

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM (2010) Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 28(11):1963–1972. https://doi.org/10.1200/JCO.2009.26.3541

Article  PubMed  Google Scholar 

Ellingson BM, Wen PY, Cloughesy TF (2017) Modified Criteria for Radiographic Response Assessment in Glioblastoma clinical trials. Neurotherapeutics 14(2):307–320. https://doi.org/10.1007/s13311-016-0507-6

Article  PubMed  PubMed Central  Google Scholar 

Koukourakis MI, Giatromanolaki A, Simopoulos C, Polychronidis A, Sivridis E (2005) Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer. Clin Exp Metastasis. 22(1):25–30. https://doi.org/10.1007/s10585-005-2343-7

Cairns RA, Harris IS, Mak TW (2011) Regulation of cancer cell metabolism. Nat Rev Cancer. 11(2):85–95. https://doi.org/10.1038/nrc2981

San-Millán I, Brooks GA (2017) Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect. Carcinogenesis 38(2):119–133. https://doi.org/10.1093/carcin/bgw127

Article  CAS  PubMed  Google Scholar 

Chen N, Peng C, Li D (2022) Epigenetic underpinnings of inflammation: a Key to unlock the Tumor Microenvironment in Glioblastoma. Front Immunol 13:869307. https://doi.org/10.3389/fimmu.2022.869307

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Z et al (2020) Lactate dehydrogenase promotes the polarization of tumor-associated macrophages toward the M2 phenotype via the HIF-1α pathway in glioblastoma. Signal Transduct Target Therapy 5(1):226

Google Scholar 

Koukourakis MI, Giatromanolaki A, Sivridis E, Bougioukas G, Didilis V, Gatter KC, Harris AL, Tumour and Angiogenesis Research Group (2003) Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br J Cancer 89(5):877–885. https://doi.org/10.1038/sj.bjc.6601205

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fantin VR, St-Pierre J, Leder P (2006) Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell. 9(6):425– 34. https://doi.org/10.1016/j.ccr.2006.04.023. Erratum in: Cancer Cell. 2006;10(2):172

Jin MZ, Jin WL (2020) The updated landscape of tumor microenvironment and drug repurposing. Signal Transduct Target Ther 5(1):166. https://doi.org/10.1038/s41392-020-00280-x

Article  PubMed  PubMed Central  Google Scholar 

Stanke KM, Wilson C, Kidambi S (2021) High expression of glycolytic genes in clinical glioblastoma patients correlates with Lower Survival. Front Mol Biosci 8:752404. https://doi.org/10.3389/fmolb.2021.752404

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernhard C, Reita D, Martin S, Entz-Werle N, Dontenwill M (2023) Glioblastoma metabolism: insights and therapeutic strategies. Int J Mol Sci 24(11):9137. https://doi.org/10.3390/ijms24119137

Article  CAS  PubMed  PubMed Central  Google Scholar 

de la Cruz-López KG, Castro-Muñoz LJ, Reyes-Hernández DO, García-Carrancá A, Manzo-Merino J (2019) Lactate in the regulation of Tumor Microenvironment and therapeutic approaches. Front Oncol 9:1143. https://doi.org/10.3389/fonc.2019.01143

Article  PubMed  PubMed Central  Google Scholar 

Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Grant Rowe R, Wainwright DA, McCortney K, Billingham LK, Miska J, Horbinski C, Lesniak MS, Chen P (2024) Lactate dehydrogenase a regulates tumor-macrophage symbiosis to promote glioblastoma progression. Nat Commun 15(1):1987. https://doi.org/10.1038/s41467-024-46193-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M (2016) LDHA-Associated Lactic Acid Production blunts Tumor Immunosurveillance by T and NK Cells. Cell Metab 24(5):657–671. https://doi.org/10.1016/j.cmet.2016.08.011

Article  CAS  PubMed  Google Scholar