Molecular Secrets Revealed: How Diabetes may be Paving the Way for Leukemia

Antar SA, Ashour NA, Sharaky M, Khattab M, Ashour NA, Zaid RT, et al. Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomed Pharmacother. 2023;168:115734.

Article  CAS  PubMed  Google Scholar 

Buzzetti R, Maddaloni E, Gaglia J, Leslie RD, Wong FS, Boehm BO. Adult-onset autoimmune diabetes. Nat Rev Dis Primers. 2022;8(1):63.

Article  PubMed  Google Scholar 

Aksoy M, Erdem S, Dinçol G. Types of leukemia in chronic benzene poisoning. A study in thirty-four patients. Acta haematologica. 1976;55(2):65–72.

Article  CAS  PubMed  Google Scholar 

Scappaticcio L, Maiorino MI, Bellastella G, Giugliano D, Esposito K. Insights into the relationships between diabetes, prediabetes, and cancer. Endocrine. 2017;56(2):231–9.

Article  CAS  PubMed  Google Scholar 

Noto H, Tsujimoto T, Sasazuki T, Noda M. Significantly increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis. Endocr Pract. 2011;17(4):616–28.

Article  PubMed  Google Scholar 

Castillo JJ, Mull N, Reagan JL, Nemr S, Mitri J. Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies. Blood. 2012;119(21):4845–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan P, Wang Y, Fu T, Liu Y, Zhang Z-J. The association between type 1 and 2 diabetes mellitus and the risk of leukemia: a systematic review and meta-analysis of 18 cohort studies. Endocr J. 2021;68(3):281–9.

Article  CAS  PubMed  Google Scholar 

Nagel G, Stocks T, Späth D, Hjartåker A, Lindkvist B, Hallmans G, et al. Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can). Ann Hematol. 2012;91:1519–31.

Article  CAS  PubMed  Google Scholar 

Mitri J, Castillo J, Pittas AG. Diabetes and risk of Non-Hodgkin’s lymphoma: a meta-analysis of observational studies. Diabetes Care. 2008;31(12):2391–7.

Article  PubMed  PubMed Central  Google Scholar 

Gallagher EJ, LeRoith D. Diabetes, antihyperglycemic medications and cancer risk: smoke or fire? Curr Opin Endocrinol Diabetes Obes. 2013;20(5):485–94.

Article  CAS  PubMed  Google Scholar 

Campbell PT, Newton CC, Patel AV, Jacobs EJ, Gapstur SM. Diabetes and cause-specific mortality in a prospective cohort of one million US adults. Diabetes Care. 2012;35(9):1835–44.

Article  PubMed  PubMed Central  Google Scholar 

Karmali R, Dalovisio A, Borgia JA, Venugopal P, Kim BW, Grant-Szymanski K, et al. All in the family: clueing into the link between metabolic syndrome and hematologic malignancies. Blood Rev. 2015;29(2):71–80.

Article  CAS  PubMed  Google Scholar 

Braun S, Bitton-Worms K, LeRoith D. The link between the metabolic syndrome and cancer. Int J Biol Sci. 2011;7(7):1003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hemminki K, Li X, Sundquist J, Sundquist K. Risk of cancer following hospitalization for type 2 diabetes. Oncologist. 2010;15(6):548–55.

Article  PubMed  PubMed Central  Google Scholar 

Tahrani AA, Cramp C, Moulik P. The development of non-insulin-dependent diabetes after total body irradiation and bone marrow transplantation in adolescence: a case report and literature review. Pediatr Diabetes. 2006;7(3):173–5.

Article  PubMed  Google Scholar 

Hirayama M, Azuma E, Kumamoto T, Qi J, Kobayashi M, Komada Y, et al. Late-onset unilateral renal dysfunction combined with non-insulin-dependent diabetes mellitus and bronchial asthma following allogeneic bone marrow transplantation for acute lymphoblastic leukemia in a child. Bone Marrow Transplant. 1998;22(9):923–6.

Article  CAS  PubMed  Google Scholar 

Rotbain EC, Niemann CU, Rostgaard K, da Cunha-Bang C, Hjalgrim H, Frederiksen H. Mapping comorbidity in chronic lymphocytic leukemia: impact of individual comorbidities on treatment, mortality, and causes of death. Leukemia. 2021;35(9):2570–80.

Article  PubMed  Google Scholar 

Strati P, Parikh SA, Chaffee KG, Kay NE, Call TG, Achenbach SJ, et al. Relationship between co-morbidities at diagnosis, survival and ultimate cause of death in patients with chronic lymphocytic leukaemia (CLL): a prospective cohort study. Br J Haematol. 2017;178(3):394–402.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thurmes P, Call T, Slager S, Zent C, Jenkins G, Schwager S, et al. Comorbid conditions and survival in unselected, newly diagnosed patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2008;49(1):49–56.

Article  PubMed  Google Scholar 

Lipscombe LL, Hwee J, Webster L, Shah BR, Booth GL, Tu K. Identifying diabetes cases from administrative data: a population-based validation study. BMC Health Serv Res. 2018;18:1–8.

Article  Google Scholar 

Holowaty EJ, Norwood TA, Wanigaratne S, Abellan JJ, Beale L. Feasibility and utility of mapping disease risk at the neighbourhood level within a Canadian public health unit: an ecological study. Int J Health Geogr. 2010;9:1–14.

Article  Google Scholar 

Garg SS, Kushwaha K, Dubey R, Gupta J. Association between obesity, inflammation and insulin resistance: Insights into signaling pathways and therapeutic interventions. Diabetes Res Clin Pract. 2023;200:110691.

Article  Google Scholar 

Tsilingiris D, Vallianou NG, Spyrou N, Kounatidis D, Christodoulatos GS, Karampela I, et al. Obesity and leukemia: biological mechanisms, perspectives, and challenges. Curr Obes Rep. 2024;13(1):1–34.

Article  PubMed  Google Scholar 

Matos A, Marinho-Dias J, Ramalheira S, Oliveira MJ, Bicho M, Ribeiro R. Mechanisms underlying the association between obesity and Hodgkin lymphoma. Tumor Biology. 2016;37:13005–16.

Article  CAS  PubMed  Google Scholar 

Rozovski U, Hazan-Halevy I, Barzilai M, Keating MJ, Estrov Z. Metabolism pathways in chronic lymphocytic leukemia. Leuk Lymphoma. 2016;57(4):758–65.

Article  CAS  PubMed  Google Scholar 

Pietropaolo M, Barinas-Mitchell E, Pietropaolo SL, Kuller LH, Trucco M. Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes. Diabetes. 2000;49(1):32–8.

Article  CAS  PubMed  Google Scholar 

Neville KA, Cohn RJ, Steinbeck KS, Johnston K, Walker JL. Hyperinsulinemia, impaired glucose tolerance, and diabetes mellitus in survivors of childhood cancer: prevalence and risk factors. J Clin Endocrinol Metab. 2006;91(11):4401–7.

Article  CAS  PubMed  Google Scholar 

Marnell CS, Bick A, Natarajan P. Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease. J Mol Cell Cardiol. 2021;161:98–105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maddatu J, Anderson-Baucum E, Evans-Molina C. Smoking and the risk of type 2 diabetes. Transl Res. 2017;184:101–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akter S, Goto A, Mizoue T. Smoking and the risk of type 2 diabetes in Japan: a systematic review and meta-analysis. J Epidemiol. 2017;27(12):553–61.

Article  PubMed  PubMed Central  Google Scholar 

Ugai T, Matsuo K, Sawada N, Iwasaki M, Yamaji T, Shimazu T, et al. Smoking and subsequent risk of leukemia in Japan: the Japan public health center-based prospective study. J Epidemiol. 2017;27(7):305–10.

Article  PubMed  PubMed Central  Google Scholar

留言 (0)

沒有登入
gif