Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses

Abram SE, Yi J, Fuchs A, Hogan QH (2006) Permeability of injured and intact peripheral nerves and dorsal root ganglia. Anesthesiology 105:146–153. https://doi.org/10.1016/S0304-3959(00)00276-1

Article  PubMed  Google Scholar 

Bai L, Wang X, Li Z, Kong C, Zhao Y, Qian JL, Kan Q, Zhang W, Xu JT (2016) Upregulation of chemokine CXCL12 in the dorsal root ganglia and spinal cord contributes to the development and maintenance of neuropathic pain following spared nerve injury in rats. Neurosci Bull 32:27–40. https://doi.org/10.1523/JNEUROSCI.2235-16.2016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banisadr G, Skrzydelski D, Kitabgi P, Rostene W, Parsadaniantz SM (2003) Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons. Eur J Neurosci 18:1593–1606

Article  PubMed  Google Scholar 

Baral P, Udit S, Chiu IM (2019) Pain and immunity: implications for host defence. Nat Rev Immunol 19:433–447

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhangoo SK, Ren D, Miller RJ, Chan DM, Ripsch MS, Weiss C, McGinnis C, White FA (2007) CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy. Brain Behav Immun 21:581–591

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calvo M, Dawes JM, Bennett DL (2012) The role of the immune system in the generation of neuropathic pain. Lancet Neurol 11:629–642

Article  CAS  PubMed  Google Scholar 

Campana WM (2007) Schwann cells: activated peripheral glia and their role in neuropathic pain. Brain Behav Immun 21:522–527

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capecchi R, Croia C, Puxeddu I, Pratesi F, Cacciato A, Campani D, Boggi U, Morelli L, Tavoni A, Migliorini P (2021) CXCL12/SDF-1 in IgG4-related disease. Front Pharmacol 12:750216

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55–63

Article  CAS  PubMed  Google Scholar 

Chatterjee M, Gawaz M (2013) Platelet-derived CXCL12 (SDF-1alpha): basic mechanisms and clinical implications. J Thromb Haemost 11:1954–1967

Article  CAS  PubMed  Google Scholar 

Chen G, Xu J, Luo H, Luo X, Singh SK, Ramirez JJ, James ML, Mathew JP, Berger M, Eroglu C et al (2022) Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling. JCI Insight 7:e161028

Article  PubMed  PubMed Central  Google Scholar 

Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB et al (2017) Neuropathic pain. Nat Rev Dis Primers 3:17002

Article  PubMed  PubMed Central  Google Scholar 

Cui H, Li Z, Chen S, Li X, Chen D, Wang J, Li Z, Hao W, Zhong F, Zhang K et al (2022) CXCL12/CXCR4-Rac1-mediated migration of osteogenic precursor cells contributes to pathological new bone formation in ankylosing spondylitis. Sci Adv 8:eabl8054

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dahan A, van Velzen M, Niesters M (2014) Comorbidities and the complexities of chronic pain. Anesthesiology 121:675–677

Article  PubMed  Google Scholar 

Davies AJ, Kim HW, Gonzalez-Cano R, Choi J, Back SK, Roh SE, Johnson E, Gabriac M, Kim MS, Lee J et al (2019) Natural killer cells degenerate intact sensory afferents following nerve injury. Cell 176:716-728 e718

Article  CAS  PubMed  PubMed Central  Google Scholar 

Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain Pain 87(2):149–158. https://doi.org/10.1016/S0304-3959(00)00276-1

Dydyk A.M, Conermann T (2024) Chronic pain. In StatPearls. Treasure Island: ineligible companies. Disclosure: Till Conermann declares no relevant financial relationships with ineligible companies

Finnerup NB, Kuner R, Jensen TS (2021) Neuropathic pain: from mechanisms to treatment. Physiol Rev 101:259–301

Article  CAS  PubMed  Google Scholar 

Finnerup NB, Nikolajsen L, Rice ASC (2022) Transition from acute to chronic pain: a misleading concept? Pain 163:e985–e988

Article  PubMed  Google Scholar 

Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M et al (2016) Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci 19:94–101

Article  CAS  PubMed  Google Scholar 

Gui WS, Wei X, Mai CL, Murugan M, Wu LJ, Xin WJ, Zhou LJ, Liu XG (2016) Interleukin-1beta overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents. Mol Pain 12:1–5

Article  Google Scholar 

Hansen IB, Ellingsen T, Hornung N, Poulsen JH, Lottenburger T, Stengaard-Pedersen K (2006) Plasma level of CXC-chemokine CXCL12 is increased in rheumatoid arthritis and is independent of disease activity and methotrexate treatment. J Rheumatol 33:1754–1759

CAS  PubMed  Google Scholar 

He W, Wang M, Wang Y, Wang Q, Luo B (2016) Plasma and synovial fluid CXCL12 levels are correlated with disease severity in patients with knee osteoarthritis. J Arthroplasty 31:373–377

Article  CAS  PubMed  Google Scholar 

Hiraga SI, Itokazu T, Nishibe M, Yamashita T (2022) Neuroplasticity related to chronic pain and its modulation by microglia. Inflamm Regen 42:15

Article  PubMed  PubMed Central  Google Scholar 

Hu XM, Yang W, Zhang MT, Du LX, Tian JH, Zhu JY, Chen Y, Hai F, Liu SB, Mao-Ying QL et al (2021) Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance. Sci Signal 14:eabe3773

Article  CAS  PubMed  Google Scholar 

Iyengar S, Ossipov MH, Johnson KW (2017) The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. Pain 158:543–559

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacobs JM, Macfarlane RM, Cavanagh JB (1976) Vascular leakage in the dorsal root ganglia of the rat, studied with horseradish peroxidase. J Neurol Sci 29:95–107

Article  CAS  PubMed  Google Scholar 

Jayaraj ND, Bhattacharyya BJ, Belmadani AA, Ren D, Rathwell CA, Hackelberg S, Hopkins BE, Gupta HR, Miller RJ, Menichella DM (2018) Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy. J Clin Invest 128:2205–2225

Article  PubMed  PubMed Central  Google Scholar 

Ji J, He Q, Luo X, Bang S, Matsuoka Y, McGinnis A, Nackley AG, Ji RR (2021) IL-23 enhances C-fiber-mediated and blue light-induced spontaneous pain in female mice. Front Immunol 12:787565

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji RR, Baba H, Brenner GJ, Woolf CJ (1999) Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 2:1114–1119

Article  CAS  PubMed  Google Scholar 

Ji RR, Chamessian A, Zhang YQ (2016) Pain regulation by non-neuronal cells and inflammation. Science 354:572–577

Article  CAS  PubMed  PubMed Central 

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