American Society of Hematology (ASH) update 2023—chronic lymphocytic leukemia

Wendtner CM, Al-Sawaf O, Binder M, Dreger P, Eichhorst B, Gregor M, et al. Onkopedia Guidelines für CLL. 2023.

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Hillmen P, Cairns DA, Bloor A, Allsup D, Cwynarski K, Pettitt, et al. Ibrutinib plus venetoclax with MRD-directed duration of treatment is superior to FCR and is a new standard of care for previously untreated CLL: report of the phase III UK NCRI FLAIR study. ASH 2023. p. Abstract 631.

Eichhorst B, Niemann C, Kater A, Fürstenau M, Von Tresckow J, Zhang C, et al. First-line venetoclax combinations in chronic lymphocytic leukemia. N Engl J Med. 2023;388:1739–54.

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Fürstenau M, Ritgen M, Robrecht S, Von Tresckow J, Zhang C, Schilhabel A, et al. First-line venetoclax combinations in fit patients with CLL: 4‑year follow-up and NGS-based MRD analysis from the phase 3 GAIA/CLL13 trial. ASH 2023. p. Abstract 635.

Moreno C, Munir T, Owen C, Follows G, Hernandez Rivas JA, Benjamini O, et al. First-line fixed-duration Ibrutinib plus Venetoclax (Ibr+Ven) versus chlorambucil plus obinutuzumab (Clb+O): 55-month follow-up from the glow study. Abstract 634. ASH 2023.

Sharman J, Egyed M, Jurczak W, Skarbnik A, Patel K, Flinn IW, et al. Acalabrutinib ± Obinutuzumab vs Obinutuzumab + Chlorambucil in treatment-naive chronic lymphocytic leukemia: 6‑year follow-up of elevate-TN. ASH 2023. p. Abstract 636.

Tam C, Anderson MA, Lasica M, Verner E, Opat S, Ma S, et al. Combination Treatment with Sonrotoclax (BGB-11417), a Second-Generation BCL2 Inhibitor, and Zanubrutinib, a Bruton Tyrosine Kinase (BTK) Inhibitor, Is Well Tolerated and Achieves Deep Responses in Patients with Treatment-Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (TN-CLL/SLL): Data from an Ongoing Phase 1/2 Study. ASH 2023, Abstract 327

Brown J, Eichhorst B, Lamanna N, O´Brien S, Tam C, Qiu L, et al. Extended follow-up of ALPINE randomized phase 3 study confirms sustained superior progression-free survival of zanubrutinib versus Ibrutinib for treatment of relapsed/refractory chronic lymphocytic leukemia and small lymphocytic Lymphoma (R/R CLL/SLL). ASH 2023. p. Abstract 202.

Woyach J, Brown J, Ghia P, Roeker L, Patel K, Eyre T, et al. Pirtobrutinib in post-cBTKi CLL/SLL: ~30 months follow-up and subgroup analysis with/without prior BCL2i from the phase 1/2 BRUIN study. ASH 2023. p. Abstract 325.

Al-Sawaf O, Ligtvoet R, Robrecht S, Stumpf J, Fink AM, Tausch E, et al. Tislelizumab plus zanubrutinib in patients with richter transformation: primary endpoint analysis of the prospective, multi-center, phase-II RT1 trial of the German CLL study group. ASH 2023. p. Abstract 204.

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