Lung cancersmall-cell lung cancer (SCLC)Zhou Rui 2015PTPRU, EPAS1metastasismiR-574-5p significantly enhances the metastasis of SCLC and participates in β-catenin signaling by Suppressing protein tyrosine phosphatase receptor type U (PTPRU) or endothelial PAS domain protein 1 (EPAS1).↑↓Wnt/β-cateninnon-small cell lung cancer (NSCLC)Saul et al., 2019CUGBP1induce mPGES-1 expression, PGE formation and tumor growthmiR-574-5p induces microsomal prostaglandin E synthase-1 (mPGES-1) expression by preventing CUGBP1 binding to its 3’UTR, leading to enhanced alternative splicing and generation of an mPGES-1 3’UTR isoform, increased mPGES-1 protein expression, and PGE formation↑↓NAEmmerich 2020CUGBP1induce mPGES-1 expression, PGE formation and tumor growthmiR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.↑↓NAZhou Rui 2016PTPRUcell migration and invasionmiR-574-5p enhances the tyrosine phosphorylation of β-catenin by repressing PTPRU expression and promotes the migration and invasion of NSCLC cells.↑↓Wnt/β-cateninHua Peng 2016nonediagnostic biomarkermiR-574-5p can serve as a convenient tool for early NSCLC diagnosis.↓NANAKristen M. 2011nonediagnostic biomarkerhsa-miR-574-5p is significantly increased in early-stage NSCLC samples.↑NANAlung adenocarcinomaZhijun Han 2020nonediagnostic biomarkerCirculating exosomal miR-574-5p has potential to serve as novel diagnostic biomarkers for early-stage LA.↑NANAGastric cancernot-mentionedZhengyi Zhang 2019QKI6cell proliferation, growth and invasionThe increase in miR-574-5p/-3p ratio, named miR-574 arm-imbalance, is partially due to the dynamic expression of their highly complementary targets in gastric carcinogenesis; the arm-imbalance of miR-574 is in turn involved and further promotes gastric cancer progression.↑↓NAnot-mentionedShu Zhang, 2020PTPN3angiogenesismiR-574-5p in gastric cancer cells promotes angiogenesis via enhancing phosphorylation of p44/42 MAPKs by miR-574-5p inhibition of PTPN3 expression.↑↓MAPKsnot-mentionedJianming Li 2014nonemaintaining the stemness
of the gastric CSCsmiR-574-5p shows decreased expression pattern in gastric CSCs↓↑NAColorectal cancernot-mentionedShunlong Ji 2012Qki6/7cell proliferation, migration, invasion, differentiation and cell cycleUpregulation of miR-574-5p decreases the expression of Qk6/7 to inhibit b-catenin mRNA and protein expression and inhibit B-catenin /Wnt signal transduction in CRC cells↑↓Wnt/β-catenincolorectal cancer liver metastasisZhe Cui, 2014MACC-1liver metastasishsa-miR-574-5p plays a suppressive role in colorectal cancer liver metastasis by negatively directing MACC-1 expression↓↑NAEsophageal squamous cell carcinoma not-mentionedDeqiang Zheng 2019nonediagnostic and prognostic biomarkermiR574 can distinguish ESCC patients from healthy controls. Moreover, the classifying performance of the miRNA panel can discriminate healthy controls from patients with ESCC stage I-II (AUC > 0.76) and patients with ESCC stage III-IV (AUC > 0.80).↑↓NAnot-mentionedMIAO YANG 2013nonediagnostic biomarkerhsa-miR-574-5p is upregulated in tumor tissues; multiple regression analysis revealed the aberrant expression of hsa-miR-574-5p increases the risk of esophageal cancer.↑↓NAnot-mentionedJie Li 2021SMAD4cell proliferation and apoptosismiR-574-5p represses the abundance of ESCC cells, which leads to booming cell growth of ESCC.↑↓NAnot-mentionedGuo Liang Han 2020ZNF70cell proliferation and apoptosismiR-574-5p serve as a tumor promoter regulating cells proliferation and apoptosis in ESCC through and MAPK pathways. Furthermore, ZNF70 has been proven to be a functional target for miR-574-5p to regulate cells proliferation and apoptosis↑↓MAPKs Breast cancertriple-negative breast cancerKE-JING ZHANG 2020BCL11A, SOX2cell proliferation, migration and EMTmiR-574-5p attenuates proliferation, migration, and EMT in triple-negative breast cancer cells by targeting BCL11A and SOX2 to inhibit the SKIL/TAZ/CTGF axis.↓↑NAnot-mentionedSheng-kai Huang 2018nonediagnostic and prognostic biomarkermiR-574-5p might represent a serum biomarker panel with potential in the diagnosis of breast cancer.↑ NAestrogen receptor (ER) positive breast cancer Margherita Piccolella 2021HSPB8cell proliferation and migrationDownregulation of miR-574-5p, which binds to HSPB8 ORF, causes increased expression of HSPB8 protein and the proliferation and migration of ER+BC MCF-7 cells.↓↑NAThyroid cancernot-mentionedZhejia Zhang 2018QKIcell cycle and migration miR-574-5p mediates the cell cycle and apoptosis in thyroid cancer cells via Wnt/β-catenin signaling by repressing the expression of Quaking proteins.↑↓Wnt/β-cateninnot-mentionedZhe-JiaZhang 2020FOXN3cell migration, proliferation, invasion and apoptosis miR-574-5p directly targets FOXN3 in thyroid cancer cells, which activates Wnt/β-catenin singling pathway and promotes cell migration, proliferation, invasion and apoptosis↑↓(pathway activated)Wnt/β-cateninpapillary thyroid carcinoma (PTC) Xiaoming Wang 2017SCAIcell proliferation and migrationPTCSC3 absorbs miR-574-5p, and miR-574-5p targets SCAI; SCAI can regulate the activity of Wnt/β-catenin. PTCSC3/miR-574-5p regulates the activity of Wnt/β-catenin via SCAI and mediates cell proliferation and migration of PTC-1.↑↓Wnt/β-catenin and non-coding RNAChordomanot-mentionedEmre Can Tuysuza 2019MYCBPcell viability, apoptosis, migration and invasionmiR-574-5p targets MYCBP and inhibits the invasive and migratory phenotype; miR-574-5p decreases viability and increases apoptosis in U-CH1 cells while it has no effect on both viability and apoptosis in MUG-Chor1 cells.↓↑NAHead and neck squamous cell carcinoma chemotherapy-induced cell death and nodal metastasisMarisa Meyers-Needham 2011CerS1-2cell proliferation and growthInhibition of HDAC1 and siRNA-mediated knockdown of miR-574-5p reconstitutes CerS1-2 expression and C18-ceramide generation, which subsequently inhibits cancer cell proliferation.↑↓NA