Rinaldi L, Guarino M, Perrella A, Pafundi PC, Valente G, Fontanella L, Nevola R, Guerrera B, Iuliano N, Imparato M, et al. Role of Liver Stiffness Measurement in Predicting HCC occurrence in direct-acting antivirals setting: a real-life experience. Dig Dis Sci. 2019;64(10):3013–9.

Article  PubMed  Google Scholar 

Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391(10127):1301–14.

Article  PubMed  Google Scholar 

Villanueva A. Hepatocellular Carcinoma. N Engl J Med. 2019;380(15):1450–62.

Article  PubMed  CAS  Google Scholar 

Sugawara Y, Hibi T. Surgical treatment of hepatocellular carcinoma. Biosci Trends. 2021;15(3):138–41.

Article  PubMed  Google Scholar 

Vibert E, Schwartz M, Olthoff KM. Advances in resection and transplantation for hepatocellular carcinoma. J Hepatol. 2020;72(2):262–76.

Article  PubMed  CAS  Google Scholar 

Wang K, Wang C, Jiang H, Zhang Y, Lin W, Mo J, Jin C. Combination of ablation and immunotherapy for Hepatocellular Carcinoma: where we are and where to go. Front Immunol. 2021;12:792781.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ando Y, Kawaoka T, Amioka K, Naruto K, Ogawa Y, Yoshikawa Y, Kikukawa C, Kosaka Y, Uchikawa S, Morio K, et al. Efficacy and safety of Lenvatinib-Transcatheter arterial chemoembolization sequential therapy for patients with Intermediate-Stage Hepatocellular Carcinoma. Oncology. 2021;99(8):507–17.

Article  PubMed  CAS  Google Scholar 

Cramer P. Organization and regulation of gene transcription. Nature. 2019;573(7772):45–54.

Article  PubMed  CAS  Google Scholar 

Field A, Adelman K. Evaluating enhancer function and transcription. Annu Rev Biochem. 2020;89:213–34.

Article  PubMed  CAS  Google Scholar 

Pang B, van Weerd JH, Hamoen FL, Snyder MP. Identification of non-coding silencer elements and their regulation of gene expression. Nat Rev Mol Cell Biol. 2023;24(6):383–95.

Article  PubMed  CAS  Google Scholar 

Zabidi MA, Stark A. Regulatory enhancer-core-promoter communication via transcription factors and cofactors. Trends Genet. 2016;32(12):801–14.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Banerji J, Rusconi S, Schaffner W. Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell. 1981;27(2 Pt 1):299–308.

Article  PubMed  CAS  Google Scholar 

Grosveld F, van Assendelft GB, Greaves DR, Kollias G. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell. 1987;51(6):975–85.

Article  PubMed  CAS  Google Scholar 

Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 2013;153(2):307–19.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Moorthy SD, Davidson S, Shchuka VM, Singh G, Malek-Gilani N, Langroudi L, Martchenko A, So V, Macpherson NN, Mitchell JA. Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes. Genome Res. 2017;27(2):246–58.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pott S, Lieb JD. What are super-enhancers? Nat Genet. 2015;47(1):8–12.

Article  PubMed  CAS  Google Scholar 

Tang F, Yang Z, Tan Y, Li Y. Super-enhancer function and its application in cancer targeted therapy. NPJ Precis Oncol. 2020;4:2.

Article  PubMed  PubMed Central  Google Scholar 

Scholz BA, Sumida N, de Lima CDM, Chachoua I, Martino M, Tzelepis I, Nikoshkov A, Zhao H, Mehmood R, Sifakis EG, et al. WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating. Nat Genet. 2019;51(12):1723–31.

Article  PubMed  CAS  Google Scholar 

Zhang T, Xia W, Song X, Mao Q, Huang X, Chen B, Liang Y, Wang H, Chen Y, Yu X, et al. Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway. J Hematol Oncol. 2022;15(1):114.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bacabac M, Xu W. Oncogenic super-enhancers in cancer: mechanisms and therapeutic targets. Cancer Metastasis Rev. 2023;42(2):471–80.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cao Z, Shu Y, Wang J, Wang C, Feng T, Yang L, Shao J, Zou L. Super enhancers: pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML). Genes Dis. 2022;9(6):1466–77.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen X, Ma Q, Shang Z, Niu Y. Super-enhancer in prostate cancer: transcriptional disorders and therapeutic targets. NPJ Precis Oncol. 2020;4(1):31.

Article  PubMed  PubMed Central  Google Scholar 

Liu Q, Guo L, Lou Z, Xiang X, Shao J. Super-enhancers and novel therapeutic targets in colorectal cancer. Cell Death Dis. 2022;13(3):228.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shin HY. Targeting super-enhancers for Disease Treatment and diagnosis. Mol Cells. 2018;41(6):506–14.

PubMed  PubMed Central  CAS  Google Scholar 

Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA. Super-enhancers in the control of cell identity and disease. Cell. 2013;155(4):934–47.

Article  PubMed  CAS  Google Scholar 

Buenrostro JD, Wu B, Chang HY, Greenleaf WJ. ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. Curr Protoc Mol Biol 2015, 109:21.29.21–21.29.29.

Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A. 2010;107(50):21931–6.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Grandi FC, Modi H, Kampman L, Corces MR. Chromatin accessibility profiling by ATAC-seq. Nat Protoc. 2022;17(6):1518–52.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kaya-Okur HS, Wu SJ, Codomo CA, Pledger ES, Bryson TD, Henikoff JG, Ahmad K, Henikoff S. CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat Commun. 2019;10(1):1930.

Article  PubMed  PubMed Central  Google Scholar 

Abuín JM, Pichel JC, Pena TF, Amigo J. BigBWA: approaching the Burrows-Wheeler aligner to Big Data technologies. Bioinformatics. 2015;31(24):4003–5.

Article  PubMed  Google Scholar 

Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137.

Article  PubMed  PubMed Central