Aghaie T, Jazayeri MH, Manian M, Khani L, Erfani M, Rezayi M, Ferns GA, Avan A (2019) Gold nanoparticle and polyethylene glycol in neural regeneration in the treatment of neurodegenerative diseases. J Cell Biochem 120(3):2749–2755. https://doi.org/10.1002/jcb.27415

Article  CAS  PubMed  Google Scholar 

Andreasen M, Nedergaard S (2021) Effect of acute mitochondrial dysfunction on hyperexcitable network activity in rat hippocampus in vitro. Brain Res 1751:147193. https://doi.org/10.1016/j.brainres.2020.147193

Article  CAS  PubMed  Google Scholar 

Baumann A, Tuerck D, Prabhu S, Dickmann L, Sims J (2014) Pharmacokinetics, metabolism and distribution of pegs and pegylated proteins: quo vadis? Drug Discov Today 19(10):1623–1631. https://doi.org/10.1016/j.drudis.2014.06.002

Article  CAS  PubMed  Google Scholar 

Burgova EN, Vanin AF, Demurov EA, Proshina IV (1989) Effect of the hyperbaric oxygenation of animals and man on mitochondrial function in their tissues (based on epr study data). Izv Akad Nauk Sssr Biol 2:191–197

Google Scholar 

Chakraborty J, Caicci F, Roy M, Ziviani E (2020) Investigating mitochondrial autophagy by routine transmission electron microscopy: seeing is believing? Pharmacol Res 160:105097. https://doi.org/10.1016/j.phrs.2020.105097

Article  CAS  PubMed  Google Scholar 

Chavko M, Harabin AL (1996) Regional lipid peroxidation and protein oxidation in rat brain after hyperbaric oxygen exposure. Free Radic Biol Med 20(7):973–978. https://doi.org/10.1016/0891-5849(95)02181-7

Article  CAS  PubMed  Google Scholar 

Chen H, Quick E, Leung G, Hamann K, Fu Y, Cheng JX, Shi R (2009) Polyethylene glycol protects injured neuronal mitochondria. Pathobiology 76(3):117–128. https://doi.org/10.1159/000209389

Article  CAS  PubMed  Google Scholar 

Chu J, Li H, Yuan Z, Zhou W, Yu Y, Yu Y (2023) Acetaminophen impairs ferroptosis in the hippocampus of septic mice by regulating glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways. Brain Behav 13(8):e3145. https://doi.org/10.1002/brb3.3145

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciarlone GE, Hinojo CM, Stavitzski NM, Dean JB (2019) Cns function and dysfunction during exposure to hyperbaric oxygen in operational and clinical settings. Redox Biol 27:101159. https://doi.org/10.1016/j.redox.2019.101159

Article  CAS  PubMed  PubMed Central  Google Scholar 

Costa DA, Ganilha JS, Barata PC, Guerreiro FG (2019) Seizure frequency in more than 180,000 treatment sessions with hyperbaric oxygen therapy - a single centre 20-year analysis. Diving Hyperb Med 49(3):167–174. https://doi.org/10.28920/dhm49.3.167-174

Article  PubMed  PubMed Central  Google Scholar 

D’Agostino DP, Putnam RW, Dean JB (2007) Superoxide (*o2- ) production in ca1 neurons of rat hippocampal slices exposed to graded levels of oxygen. J Neurophysiol 98(2):1030–1041. https://doi.org/10.1152/jn.01003.2006

Article  CAS  PubMed  Google Scholar 

Dean JB, Stavitzski NM (2022) The o(2)-sensitive brain stem, hyperoxic hyperventilation, and cns oxygen toxicity. Front Physiol 13:921470. https://doi.org/10.3389/fphys.2022.921470

Article  PubMed  PubMed Central  Google Scholar 

Demchenko IT, Suliman HB, Zhilyaey SY, Alekseeva OS, Platonova TF, Makowski MS, Piantadosi CA, Gasier HG (2022) Gat inhibition preserves cerebral blood flow and reduces oxidant damage to mitochondria in rodents exposed to extreme hyperbaric oxygen. Front Mol Neurosci 15:1062410. https://doi.org/10.3389/fnmol.2022.1062410

Article  CAS  PubMed  Google Scholar 

Freyssin A, Fauconneau B, Chassaing D, Rioux BA, Page G (2022) Chronic intraperitoneal injection of polyethylene glycol 200 in mice induces hippocampal neuroinflammation. Drug Chem Toxicol 45(5):1995–2002. https://doi.org/10.1080/01480545.2021.1894738

Article  CAS  PubMed  Google Scholar 

Guan ZB, Zhou YY, Cen Y, Feng HD, Liu WW, Yi HJ, Chen H (2021) Necrostatin-1 prolongs latency to convulsion in mice exposed to high oxygen partial pressure. Diving Hyperb Med 51(2):134–139. https://doi.org/10.28920/dhm51.2.134-139

Article  PubMed  PubMed Central  Google Scholar 

Gutsaeva DR, Suliman HB, Carraway MS, Demchenko IT, Piantadosi CA (2006) Oxygen-induced mitochondrial biogenesis in the rat hippocampus. Neuroscience 137(2):493–504. https://doi.org/10.1016/j.neuroscience.2005.07.061

Article  CAS  PubMed  Google Scholar 

Hachmo Y, Hadanny A, Abu HR, Daniel-Kotovsky M, Catalogna M, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Zemel Y, Bechor Y, Efrati S (2020) Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging (Albany Ny) 12(22):22445–22456. https://doi.org/10.18632/aging.202188

Article  CAS  PubMed  Google Scholar 

Han B, Jiang W, Liu H, Wang J, Zheng K, Cui P, Feng Y, Dang C, Bu Y, Wang QM, Ju Z, Hao J (2020) Upregulation of neuronal pgc-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion. Theranostics 10(6):2832–2848. https://doi.org/10.7150/thno.37119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hassanzadeh S, Sabetvand M, Sardar R, Aryanpour R, Namjoo Z (2023) Spinal cord injury model mitochondria connect altered function with defects of mitochondrion morphology: an ultrastructural study. Mol Neurobiol. https://doi.org/10.1007/s12035-023-03710-3

Article  PubMed  Google Scholar 

Hinojo CM, Ciarlone GE, D’Agostino DP (1985) Dean JB (2021) Exogenous ketone salts inhibit superoxide production in the rat caudal solitary complex during exposure to normobaric and hyperbaric hyperoxia. J Appl Physiol 130(6):1936–1954. https://doi.org/10.1152/japplphysiol.01071.2020

Article  CAS  Google Scholar 

Jacobson JM, Michael JR, Meyers RA, Bradley MB, Sciuto AM (1985) Gurtner GH (1992) Hyperbaric oxygen toxicity: role of thromboxane. J Appl Physiol 72(2):416–422. https://doi.org/10.1152/jappl.1992.72.2.416

Article  Google Scholar 

Jannig PR, Dumesic PA, Spiegelman BM, Ruas JL (2022) Snapshot: regulation and biology of pgc-1α. Cell 185(8):1444. https://doi.org/10.1016/j.cell.2022.03.027

Article  CAS  PubMed  Google Scholar 

Jin X, Liu MY, Zhang DF, Zhong X, Du K, Qian P, Yao WF, Gao H, Wei MJ (2019) Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing nlrp3 inflammasomes and tlr4/nf-κb signaling pathway. Cns Neurosci Ther 25(5):575–590. https://doi.org/10.1111/cns.13086

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kong X, Tang Q, Chen X, Tu Y, Sun S, Sun Z (2017) Polyethylene glycol as a promising synthetic material for repair of spinal cord injury. Neural Regen Res 12(6):1003. https://doi.org/10.4103/1673-5374.208597

Article  CAS  PubMed  PubMed Central  Google Scholar 

Körpınar Ş, Uzun H (2019) The effects of hyperbaric oxygen at different pressures on oxidative stress and antioxidant status in rats. Medicina (Kaunas) 55(5). https://doi.org/10.3390/medicina55050205

Lockard JS, Levy RH, Congdon WC, Ducharme LL (1979) Efficacy and toxicity of the solvent polyethylene glycol 400 in monkey model. Epilepsia 20(1):77–84. https://doi.org/10.1111/j.1528-1157.1979.tb04778.x

Article  CAS  PubMed  Google Scholar 

Luo J, Borgens R, Shi R (2004) Polyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injury. J Neurotrauma 21(8):994–1007. https://doi.org/10.1089/0897715041651097

Article  PubMed  Google Scholar 

Manning EP (2016) Central nervous system oxygen toxicity and hyperbaric oxygen seizures. Aerosp Med Hum Perform 87(5):477–486. https://doi.org/10.3357/AMHP.4463.2016

Article  PubMed  PubMed Central  Google Scholar