Adair TH, Montani JP. (2010). Integrated Systems Physiology: from Molecule to Function to Disease. In Angiogenesis. Morgan & Claypool Life SciencesCopyright © 2010 by Morgan & Claypool Life Sciences. https://doi.org/10.4199/c00017ed1v01y201009isp009
AL-Eitan L, Abu Kharmah H. The Effect of the synthetic cannabinoid AB-CHMINACA on the roles of vascular endothelial growth factor, Angiopoietin-1, and Angiopoietin-2 in Brain Angiogenesis. Appl Vitro Toxicol. 2023;9(3):104–15. https://doi.org/10.1089/aivt.2023.0003.
Al-Eitan L, Abusirdaneh R. The synthetic cannabinoid 5-fluoro ABICA upregulates angiogenic markers and stimulates tube formation in human brain microvascular endothelial cells. J Taibah Univ Med Sci. 2024;19(2):359–71. https://doi.org/10.1016/j.jtumed.2024.01.002.
Article PubMed PubMed Central Google Scholar
Al-Eitan L, Alahmad S. The expression analyses of GSK3B, VEGF, ANG1, and ANG2 in human brain microvascular endothelial cells treated with the synthetic cannabinoid XLR-11. Gene. 2023;878:147585. https://doi.org/10.1016/j.gene.2023.147585.
Article CAS PubMed Google Scholar
Al-Eitan L, Alkhawaldeh M. MDMB-FUBINACA influences Brain Angiogenesis and the expression of VEGF, ANG-1, and ANG-2. Curr Vasc Pharmacol. 2023;21(5):356–65. https://doi.org/10.2174/1570161121666230913093441.
Article CAS PubMed Google Scholar
Al-Eitan L, Kharmah HA. Effect of EMB-FUBINACA on brain endothelial cell angiogenesis: expression analysis of angiogenic markers. Naunyn Schmiedebergs Arch Pharmacol. 2024. https://doi.org/10.1007/s00210-024-03322-1.
Al-Eitan L, Alhusban A, Alahmad S. Effects of the synthetic cannabinoid XLR-11 on the viability and migration rates of human brain microvascular endothelial cells in a clinically-relevant model. Pharmacol Rep. 2020;72(6):1717–24. https://doi.org/10.1007/s43440-020-00123-0.
Article CAS PubMed Google Scholar
AL-Eitan LN, Alahmad SZ, ElMotasem MFM, Alghamdi MA. The synthetic cannabinoid 5F-MDMB-PICA enhances the metabolic activity and angiogenesis in human brain microvascular endothelial cells by upregulation of VEGF, ANG-1, and ANG-2. Toxicol Res. 2023. https://doi.org/10.1093/toxres/tfad068.
Al-Eitan LN, Alahmad SZ, ElMotasem MFM, Alghamdi MA. The synthetic cannabinoid 5F-MDMB-PICA enhances the metabolic activity and angiogenesis in human brain microvascular endothelial cells by upregulation of VEGF, ANG-1, and ANG-2. Toxicol Res (Camb). 2023;12(5):796–806. https://doi.org/10.1093/toxres/tfad068.
Al-Eitan LN, Zuhair S, Khair IY, Alghamdi MA. Assessment of the proliferative and angiogenic effects of the synthetic cannabinoid (R)-5-fluoro ADB on human cerebral microvascular endothelial cells. Iran J Basic Med Sci. 2024;27(3):304–10. https://doi.org/10.22038/ijbms.2023.71819.15605.
Article PubMed PubMed Central Google Scholar
Annex BH, Cooke JP. New directions in therapeutic angiogenesis and arteriogenesis in peripheral arterial disease. Circul Res. 2021;128(12):1944–57.
Bai F, Guo F, Jiang T, Wei H, Zhou H, Yin H, Zhong H, Xiong L, Wang Q. Arachidonyl-2-Chloroethylamide alleviates cerebral ischemia Injury through glycogen synthase Kinase-3β-Mediated mitochondrial Biogenesis and Functional Improvement. Mol Neurobiol. 2017;54(2):1240–53. https://doi.org/10.1007/s12035-016-9731-7.
Article CAS PubMed Google Scholar
Barceló B, Pichini S, López-Corominas V, Gomila I, Yates C, Busardò FP, Pellegrini M. Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: a case series. Forensic Sci Int. 2017;273:e10–4. https://doi.org/10.1016/j.forsciint.2017.01.020.
Article CAS PubMed Google Scholar
Barr JL, Unterwald EM. Glycogen synthase kinase-3 signaling in cellular and behavioral responses to psychostimulant drugs. Biochim Biophys Acta Mol Cell Res. 2020;1867(9):118746. https://doi.org/10.1016/j.bbamcr.2020.118746.
Article CAS PubMed PubMed Central Google Scholar
Battaglin F, Puccini A, Intini R, Schirripa M, Ferro A, Bergamo F, Loupakis F. The role of tumor angiogenesis as a therapeutic target in colorectal cancer. Expert Rev Anticancer Ther. 2018;18(3):251–66.
Article CAS PubMed PubMed Central Google Scholar
Benedicto A, Arteta B, Duranti A, Alonso-Alconada D. The synthetic cannabinoid URB447 exerts Antitumor and Antimetastatic Effect in Melanoma and Colon cancer. Pharmaceuticals (Basel). 2022;15(10). https://doi.org/10.3390/ph15101166.
Blázquez C, Casanova ML, Planas A, Del Gómez T, Villanueva C, Fernández-Aceñero MJ, Aragonés J, Huffman JW, Jorcano JL, Guzmán M. Inhibition of tumor angiogenesis by cannabinoids. Faseb J. 2003;17(3):529–31. https://doi.org/10.1096/fj.02-0795fje
Article CAS PubMed Google Scholar
Bogdanović V, Mrdjanović J, Borišev I. A review of the Therapeutic Antitumor potential of cannabinoids. J Altern Complement Med. 2017;23(11):831–6. https://doi.org/10.1089/acm.2017.0016.
Brindle NP, Saharinen P, Alitalo K. Signaling and functions of angiopoietin-1 in vascular protection. Circ Res. 2006;98(8):1014–23. https://doi.org/10.1161/01.Res.0000218275.54089.12.
Article CAS PubMed PubMed Central Google Scholar
Carmeliet P. Angiogenesis in life, disease and medicine. Nature. 2005;438(7070):932–6.
Article CAS PubMed Google Scholar
Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature. 2011;473(7347):298–307. https://doi.org/10.1038/nature10144.
Article CAS PubMed PubMed Central Google Scholar
Carpi S, Fogli S, Polini B, Montagnani V, Podestà A, Breschi MC, Nieri P. Tumor-promoting effects of cannabinoid receptor type 1 in human melanoma cells. Toxicol Vitro. 2017;40:272–9. https://doi.org/10.1016/j.tiv.2017.01.018.
Casanova ML, et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest. 2003;111(1):43–50.
Article CAS PubMed PubMed Central Google Scholar
Cerretani D, Collodel G, Brizzi A, Fiaschi AI, Menchiari A, Moretti E, Moltoni L, Micheli L. Cytotoxic effects of cannabinoids on human HT-29 colorectal adenocarcinoma cells: different mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020;21(15). https://doi.org/10.3390/ijms21155533.
Cohen K, Weinstein A. The effects of cannabinoids on executive functions: evidence from Cannabis and Synthetic Cannabinoids-A systematic review. Brain Sci. 2018;8(3). https://doi.org/10.3390/brainsci8030040.
Costas-Insua C, Seijo-Vila M, Blázquez C, Blasco-Benito S, Rodríguez-Baena FJ, Marsicano G, Guzmán M. Neuronal cannabinoid CB(1) receptors suppress the growth of Melanoma Brain metastases by inhibiting glutamatergic signalling. Cancers (Basel). 2023;15(9). https://doi.org/10.3390/cancers15092439.
Dillon M, Lopez A, Lin E, Sales D, Perets R, Jain P. Progress on Ras/MAPK Signaling Research and Targeting in blood and solid cancers. Cancers (Basel). 2021;13(20). https://doi.org/10.3390/cancers13205059.
Dudley AC, Griffioen AW. Pathological angiogenesis: mechanisms and therapeutic strategies. Angiogenesis. 2023;26(3):313–47. https://doi.org/10.1007/s10456-023-09876-7.
Article PubMed PubMed Central Google Scholar
Faiz MB, Naeem F, Irfan M, Aslam MA, Estevinho LM, Ateşşahin DA, Sharifi-Rad J. Exploring the therapeutic potential of cannabinoids in cancer by modulating signaling pathways and addressing clinical challenges. Discover Oncol. 2024;15(1):490.
Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature. 2005;438(7070):967.
Article CAS PubMed Google Scholar
Flygare J, et al. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. FEBS Lett. 2005;579(30):6885–9.
Article CAS PubMed Google Scholar
Gaunitz F, Andresen-Streichert H. Analytical findings in a non-fatal intoxication with the synthetic cannabinoid 5F-ADB (5F-MDMB-PINACA): a case report. Int J Legal Med. 2022;136(2):577–89.
Gholizadeh F, Ghahremani MH, Aliebrahimi S, Shadboorestan A, Ostad SN. Assessment of cannabinoids Agonist and Antagonist in Invasion potential of K562 Cancer cells. Iran Biomed J. 2019;23(2):153–8. https://doi.org/10.29252/.23.2.153.
Article PubMed PubMed Central Google Scholar
Glogauer J, Blay J. Cannabinoids, their cellular receptors, and effects on the invasive phenotype of carcinoma and metastasis. Cancer Rep (Hoboken). 2022;5(2):e1475. https://doi.org/10.1002/cnr2.1475.
留言 (0)