Aguirre GK, Zarahn E, D’esposito M (1998) The variability of human, BOLD hemodynamic responses. NeuroImage 8:360–369. https://doi.org/10.1006/nimg.1998.0369

Article  PubMed  Google Scholar 

Appl H, Holzammer T, Holzammer T et al (2012) Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics. Naunyn Schmiedebergs Arch Pharmacol 385:145–170. https://doi.org/10.1007/s00210-011-0704-0

Article  PubMed  Google Scholar 

Arrang JM, Garbarg M, Lancelot JC et al (1987) Highly potent and selective ligands for histamine H3-receptors. Nature 327:117–123. https://doi.org/10.1038/327117a0

Article  PubMed  Google Scholar 

Arrang JM, Garbarg M, Schwartz JC (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302:832–837. https://doi.org/10.1038/302832a0

Article  PubMed  Google Scholar 

Arumuham A, Nour MM, Veronese M et al (2023) The histamine system and cognitive function: an in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia. J Psychopharmacol Oxf Engl 37(10):1011–1022. https://doi.org/10.1177/02698811231177287

Article  Google Scholar 

Bernard JA, Mittal VA (2015) Dysfunctional activation of the cerebellum in schizophrenia: a functional neuroimaging meta-analysis. Clin Psychol Sci J Assoc Psychol Sci 3:545–566. https://doi.org/10.1177/2167702614542463

Article  Google Scholar 

Bhowmik M, Khanam R, Vohora D (2012) Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives. Br J Pharmacol 167:1398. https://doi.org/10.1111/j.1476-5381.2012.02093.x

Article  PubMed  PubMed Central  Google Scholar 

Bizon J, Foster T, Alexander G, Glisky E (2012) Characterizing cognitive aging of working memory and executive function in animal models. Front Aging Neurosci 4. https://doi.org/10.3389/fnagi.2012.00019

Bora E, Murray RM (2013) Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis? Schizophr Bull 40:744. https://doi.org/10.1093/schbul/sbt085

Article  PubMed  PubMed Central  Google Scholar 

Bowie CR, Harvey PD (2006) Cognitive deficits and functional outcome in schizophrenia. Neuropsychiatr Dis Treat 2:531–536. https://doi.org/10.2147/nedt.2006.2.4.531

Article  PubMed  PubMed Central  Google Scholar 

Brown JW, Whitehead Ca, Basso AM et al (2013) Preclinical evaluation of non-imidazole histamine H3 receptor antagonists in comparison to atypical antipsychotics for the treatment of cognitive deficits associated with schizophrenia. Int J Neuropsychopharmacol 16:889–904. https://doi.org/10.1017/S1461145712000739

Article  PubMed  Google Scholar 

Brown RE, Stevens DR, Haas HL (2001) The physiology of brain histamine. Prog Neurobiol 63:637–672. https://doi.org/10.1016/S0301-0082(00)00039-3

Article  PubMed  Google Scholar 

Burns TA, Huston JP, Spieler RE (2003) Circadian variation of brain histamine in goldfish. Brain Res Bull 59:299–301. https://doi.org/10.1016/s0361-9230(02)00914-0

Article  PubMed  Google Scholar 

Calvin OL, Redish AD (2021) Global disruption in excitation-inhibition balance can cause localized network dysfunction and schizophrenia-like context-integration deficits. PLOS Comput Biol 17:e1008985

Article  PubMed  PubMed Central  Google Scholar 

Caqueo-Urízar A, Gutiérrez-Maldonado J, Miranda-Castillo C (2009) Quality of life in caregivers of patients with schizophrenia: a literature review. Health Qual Life Outcomes 7:84. https://doi.org/10.1186/1477-7525-7-84

Article  PubMed  PubMed Central  Google Scholar 

Carter CS, MacDonald AW 3rd, Ross LL, Stenger VA (2001) Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: an event-related fMRI study. Am J Psychiatry 158:1423–1428. https://doi.org/10.1176/appi.ajp.158.9.1423

Article  PubMed  Google Scholar 

Cervellione KL, Burdick KE, Cottone JG et al (2007) Neurocognitive deficits in adolescents with schizophrenia: longitudinal stability and predictive utility for short-term functional outcome. J Am Acad Child Adolesc Psychiatry 46:867–878. https://doi.org/10.1097/chi.0b013e318054678d

Article  PubMed  Google Scholar 

Chein JM, Moore AB, Conway ARA (2011) Domain-general mechanisms of complex working memory span. NeuroImage 54:550–559

Article  PubMed  Google Scholar 

Chen Z, Li W-D, Zhu L-J et al (2002) Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats. Acta Pharmacol Sin 23:361–366

PubMed  Google Scholar 

Clapham J, Kilpatrick GJ (1992) Histamine H3 receptors modulate the release of [3H]-acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes. Br J Pharmacol 107:919–923. https://doi.org/10.1111/j.1476-5381.1992.tb13386.x

Article  PubMed  PubMed Central  Google Scholar 

Cornblatt BA, Erlenmeyer-Kimling L (1985) Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. J Abnorm Psychol 94:470–486. https://doi.org/10.1037/0021-843x.94.4.470

Article  PubMed  Google Scholar 

D’Esposito M, Postle BR (2014) The cognitive neuroscience of working memory. Annu Rev Psychol 66:115. https://doi.org/10.1146/annurev-psych-010814-015031

Article  PubMed  PubMed Central  Google Scholar 

Davidson M, Reichenberg A, Rabinowitz J et al (1999) Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. Am J Psychiatry 156:1328–1335. https://doi.org/10.1176/ajp.156.9.1328

Article  PubMed  Google Scholar 

De Almeida MA, Izquierdo I (1986) Memory facilitation by histamine. Arch Int Pharmacodyn Thérapie 283:193–198

Google Scholar 

Dong M, Lu L, Zhang L et al (2019) Quality of life in schizophrenia: a meta-analysis of comparative studies. Psychiatr Q 90:519–532. https://doi.org/10.1007/s11126-019-09633-4

Article  PubMed  Google Scholar 

Doreulee N, Yanovsky Y, Flagmeyer I et al (2001) Histamine H3 receptors depress synaptic transmission in the corticostriatal pathway. Neuropharmacology 40:106–113. https://doi.org/10.1016/S0028-3908(00)00101-5

Article  PubMed  Google Scholar 

Duma GM, Cuozzo S, Wilson L et al (2024) Excitation/inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent. Brain Commun 6:fcae231. https://doi.org/10.1093/braincomms/fcae231

Article  PubMed  PubMed Central  Google Scholar 

Eklund A, Nichols TE, Knutsson H (2016) Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates. Proc Natl Acad Sci 113:7900–7905. https://doi.org/10.1073/pnas.1602413113

Article  PubMed  PubMed Central  Google Scholar 

Ellender TJ, Huerta-Ocampo I, Deisseroth K et al (2011) Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine. J Neurosci 31:15340–15351. https://doi.org/10.1523/JNEUROSCI.3144-11.2011

Article  PubMed  PubMed Central  Google Scholar 

Faul F, Erdfelder E, Buchner A, Lang A-G (2009) Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 41:1149–1160. https://doi.org/10.3758/BRM.41.4.1149

Article  PubMed  Google Scholar 

Faul F, Erdfelder E, Lang A-G, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175–191. https://doi.org/10.3758/BF03193146

Article  PubMed  Google Scholar 

First MB, Spitzer RL, Gibbon M, Williams JBW (2002) Structured clinical interview for DSM-IV-TR Axis I disorders. Biometrics Research, New York State Psychiatric Institute, New York

Foley AG, Prendergast A, Barry C et al (2009) H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms. Neuropsychopharmacol off Publ Am Coll Neuropsychopharmacol 34:2585–2600. https://doi.org/10.1038/npp.2009.89

Article  Google Scholar 

Fox GB, Esbenshade TA, Pan JB et al (2005) Pharmacological properties of ABT-239 [4-(2--benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther 313:176–190. https://doi.org/10.1124/jpet.104.078402

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