Muslimov, A. et al. The dual role of the innate immune system in the effectiveness of mRNA therapeutics. Int. J. Mol. Sci. 24, 14820 (2023).
Article CAS PubMed PubMed Central Google Scholar
Bonelli, M. et al. Additional heterologous versus homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination: a randomised controlled trial. Ann. Rheum. Dis. 81, 687–694 (2022).
Article CAS PubMed Google Scholar
Mrak, D. et al. Heterologous vector versus homologous mRNA COVID-19 booster vaccination in non-seroconverted immunosuppressed patients: a randomized controlled trial. Nat. Commun. 13, 5362 (2022).
Article CAS PubMed PubMed Central Google Scholar
Brenner, S., Jacob, F. & Meselson, M. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature 190, 576–581 (1961).
Article CAS PubMed Google Scholar
Wolff, J. A. et al. Direct gene transfer into mouse muscle in vivo. Science 247, 1465–1468 (1990).
Article CAS PubMed Google Scholar
Hou, X., Zaks, T., Langer, R. & Dong, Y. Lipid nanoparticles for mRNA delivery. Nat. Rev. Mater. 6, 1078–1094 (2021).
Article CAS PubMed PubMed Central Google Scholar
Duke University. A safety and feasibility study of active immunotherapy in patients with metastatic prostate carcinoma using autologous dendritic cells pulsed with RNA encoding prostate specific antigen, PSA. https://clinicaltrials.gov/study/NCT00004211 (2013).
Heiser, A. et al. Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J. Clin. Investig. 109, 409–417 (2002).
Article CAS PubMed PubMed Central Google Scholar
University Hospital Tuebingen. Induction of specific immune responses against melanoma-associated antigens in vivo by intradermal vaccination with stabilized tumor mRNA—a clinical Phase I/II trial. https://clinicaltrials.gov/study/NCT00204607 (2007).
Weide, B. et al. Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. J. Immunother. 32, 498–507 (2009).
Article CAS PubMed Google Scholar
Karikó, K., Buckstein, M., Ni, H. & Weissman, D. Suppression of RNA recognition by toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165–175 (2005).
Dolgin, E. The tangled history of mRNA vaccines. Nature 597, 318–324 (2021).
Article CAS PubMed Google Scholar
Alberer, M. et al. Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial. Lancet 390, 1511–1520 (2017).
Article CAS PubMed Google Scholar
Lu, C. et al. Safety, Immunogenicity, and mechanism of a rotavirus mRNA-LNP vaccine in mice. Viruses 16, 211 (2024).
Article CAS PubMed PubMed Central Google Scholar
Yang, L., Tang, L., Zhang, M. & Liu, C. Recent advances in the molecular design and delivery technology of mRNA for vaccination against infectious diseases. Front. Immunol. 13, 896958 (2022).
Article CAS PubMed PubMed Central Google Scholar
Han, G. et al. Advances in mRNA therapeutics for cancer immunotherapy: from modification to delivery. Adv. Drug Deliv. Rev. 199, 114973 (2023).
Article CAS PubMed PubMed Central Google Scholar
Boreikaitė, V. & Passmore, L. A. 3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression. Annu. Rev. Biochem. 92, 199–225 (2023).
Article PubMed PubMed Central Google Scholar
Shen, G., Liu, J., Yang, H., Xie, N. & Yang, Y. mRNA therapies: pioneering a new era in rare genetic disease treatment. J. Control Release 369, 696–721 (2024).
Article CAS PubMed Google Scholar
Chaudhary, N., Weissman, D. & Whitehead, K. A. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat. Rev. Drug Discov. 20, 817–838 (2021).
Article CAS PubMed PubMed Central Google Scholar
Kwon, S., Kwon, M., Im, S., Lee, K. & Lee, H. mRNA vaccines: the most recent clinical applications of synthetic mRNA. Arch. Pharm. Res. 45, 245–262 (2022).
Article CAS PubMed PubMed Central Google Scholar
Bourke, A. M., Schwarz, A. & Schuman, E. M. De-centralizing the central dogma: mRNA translation in space and time. Mol. Cell 83, 452–468 (2023).
Article CAS PubMed Google Scholar
Bai, C., Wang, C. & Lu, Y. Novel vectors and administrations for mRNA delivery. Small 19, 2303713 (2023).
Su, L.-J. et al. Delivery of mRNA for cancer therapy: progress and prospects. Nano Today 53, 102013 (2023).
Ye, Z. et al. The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology. ACS Nano 17, 15231–15253 (2023).
Article CAS PubMed Google Scholar
Pan, S., Fan, R., Han, B., Tong, A. & Guo, G. The potential of mRNA vaccines in cancer nanomedicine and immunotherapy. Trends Immunol. 45, 20–31 (2024).
Article CAS PubMed Google Scholar
Metkar, M., Pepin, C. S. & Moore, M. J. Tailor made: the art of therapeutic mRNA design. Nat. Rev. Drug Discov. 23, 67–83 (2024).
Article CAS PubMed Google Scholar
Kawamoto, Y., Wu, Y., Takahashi, Y. & Takakura, Y. Development of nucleic acid medicines based on chemical technology. Adv. Drug Deliv. Rev. 199, 114872 (2023).
Article CAS PubMed Google Scholar
Cao, Q., Fang, H. & Tian, H. mRNA vaccines contribute to innate and adaptive immunity to enhance immune response in vivo. Biomaterials 310, 122628 (2024).
Article CAS PubMed Google Scholar
Sun, H., Li, K., Liu, C. & Yi, C. Regulation and functions of non-m6A mRNA modifications. Nat. Rev. Mol. Cell Biol. 24, 714–731 (2023).
Article CAS PubMed Google Scholar
Rodell, R., Robalin, N. & Martinez, N. M. Why U matters: detection and functions of pseudouridine modifications in mRNAs. Trends Biochem. Sci. 49, 12–27 (2024).
Article CAS PubMed Google Scholar
Lin, S. & Kuang, M. RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives. Nat. Rev. Gastroenterol. Hepatol. 21, 267–281 (2024).
Article CAS PubMed Google Scholar
Flamand, M. N., Tegowski, M. & Meyer, K. D. The proteins of mRNA modification: writers, readers, and erasers. Annu. Rev. Biochem. 92, 145–173 (2023).
留言 (0)