Potassium channels in depression: emerging roles and potential targets

Herrman H, Patel V, Kieling C, Berk M, Buchweitz C, Cuijpers P, et al. Time for united action on depression: a Lancet-World Psychiatric Association Commission. Lancet Lond Engl. 2022;399(10328):957–1022.

Article  Google Scholar 

Quintanilla B, Zarate CA, Pillai A. Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects? Mol Psychiatry. 2024;29(9):2849–58.

Article  CAS  PubMed  Google Scholar 

Solmi M, Fornaro M, Ostinelli EG, Zangani C, Croatto G, Monaco F, et al. Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects. World Psychiatry Off J World Psychiatr Assoc WPA. 2020;19(2):214–32.

Google Scholar 

Howes OD, Thase ME, Pillinger T. Treatment resistance in psychiatry: state of the art and new directions. Mol Psychiatry. 2022;27(1):58–72.

Article  PubMed  Google Scholar 

Imbrici P, Camerino DC, Tricarico D. Major channels involved in neuropsychiatric disorders and therapeutic perspectives. Front Genet. 2013;4:76.

Article  PubMed  PubMed Central  Google Scholar 

Moiseenkova-Bell V, Delemotte L, Minor DL. Ion channels: intersection of structure, function, and pharmacology. J Mol Biol. 2021;433(17):167102.

Article  CAS  PubMed  Google Scholar 

Krupp JJ. Role of ion channels in neurological disorders. CNS Neurol Disord Drug Targets. 2008;7(2):120–1.

Article  CAS  PubMed  Google Scholar 

Tian C, Zhu R, Zhu L, Qiu T, Cao Z, Kang T. Potassium channels: structures, diseases, and modulators. Chem Biol Drug Des. 2014;83(1):1–26.

Article  CAS  PubMed  Google Scholar 

French JA, Porter RJ, Perucca E, Brodie MJ, Rogawski MA, Pimstone S, et al. Efficacy and safety of XEN1101, a novel potassium channel opener, in adults with focal epilepsy: a phase 2b randomized clinical trial. JAMA Neurol. 2023;80(11):1145–54.

Article  PubMed  PubMed Central  Google Scholar 

Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE, Alkon DL. Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease. Proc Natl Acad Sci USA. 1993;90(17):8209–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun HS, Feng ZP. Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia. Acta Pharmacol Sin. 2013;34(1):24–32.

Article  PubMed  Google Scholar 

Catterall W, Epstein PN. Ion channels. Diabetologia. 1992;35(Suppl 2):S23-33.

Article  PubMed  Google Scholar 

Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science. 2012;338(6103):68–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baert T, Vande Casteele T, Bouckaert F, Vandenbulcke M. Neural networks in late life depression. Tijdschr Voor Psychiatr. 2023;65(10):624–8.

CAS  Google Scholar 

Zhang B, Qi S, Liu S, Liu X, Wei X, Ming D. Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression. BMC Psychiatry. 2021;21(1):280.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pongs O. Regulation of excitability by potassium channels. Results Probl Cell Differ. 2008;44:145–61.

Article  CAS  PubMed  Google Scholar 

Kuang Q, Purhonen P, Hebert H. Structure of potassium channels. Cell Mol Life Sci CMLS. 2015;72(19):3677–93.

Article  CAS  PubMed  Google Scholar 

Maljevic S, Lerche H. Potassium channels: a review of broadening therapeutic possibilities for neurological diseases. J Neurol. 2013;260(9):2201–11.

Article  CAS  PubMed  Google Scholar 

MacKinnon R. Potassium channels. FEBS Lett. 2003;555(1):62–5.

Article  CAS  PubMed  Google Scholar 

Christie MJ, North RA, Osborne PB, Douglass J, Adelman JP. Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits. Neuron. 1990;4(3):405–11.

Article  CAS  PubMed  Google Scholar 

Choe S, Kreusch A, Pfaffinger PJ. Towards the three-dimensional structure of voltage-gated potassium channels. Trends Biochem Sci. 1999;24(9):345–9.

Article  CAS  PubMed  Google Scholar 

González C, Baez-Nieto D, Valencia I, Oyarzún I, Rojas P, Naranjo D, et al. K(+) channels: function-structural overview. Compr Physiol. 2012;2(3):2087–149.

Article  PubMed  Google Scholar 

Sands Z, Grottesi A, Sansom MSP. Voltage-gated ion channels. Curr Biol CB. 2005;15(2):R44-47.

Article  CAS  PubMed  Google Scholar 

Hille B. Ionic selectivity of Na and K channels of nerve membranes. Membranes. 1975;3:255–323.

CAS  PubMed  Google Scholar 

Hu JH, Malloy C, Tabor GT, Gutzmann JJ, Liu Y, Abebe D, et al. Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility. Nat Commun. 2020;11(1):1567.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev. 2010;90(1):291–366.

Article  CAS  PubMed  Google Scholar 

Li WP, Cui XD, Cheng M. Function and expression of inwardly rectifying potassium channel Kir2.1. Sheng Li Ke Xue Jin Zhan. 2015;46(4):287–9.

CAS  PubMed  Google Scholar 

Mayfield J, Blednov YA, Harris RA. Behavioral and genetic evidence for girk channels in the CNS: role in physiology, pathophysiology, and drug addiction. Int Rev Neurobiol. 2015;123:279–313.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. International union of pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005;57(4):463–72.

Article  CAS  PubMed  Google Scholar 

Weatherall KL, Goodchild SJ, Jane DE, Marrion NV. Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010;91(3):242–55.

Article  CAS  PubMed  Google Scholar 

Kuiper EFE, Nelemans A, Luiten P, Nijholt I, Dolga A, Eisel U. K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration. Front Pharmacol. 2012;3:107.

Article  PubMed  PubMed Central  Google Scholar 

Berkefeld H, Fakler B, Schulte U. Ca2+-activated K+ channels: from protein complexes to function. Physiol Rev. 2010;90(4):1437–59.

Article  CAS  PubMed  Google Scholar 

Kim D. Physiology and pharmacology of two-pore domain potassium channels. Curr Pharm Des. 2005;11(21):2717–36.

Article 

留言 (0)

沒有登入
gif