Siegel R, Ma J, Zou Z, Jemal AJC. Cancer statistics, 2014. 2014;64(1):9–29.

Ceresoli GL, Cappuzzo F, Gregorc V, Bartolini S, Crino L, Villa EJAO. Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial. 2004;15(7):1042–7.

Reck M, Popat S, Reinmuth N, De Ruysscher D, Kerr K, Peters SJA. Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice guidelines for diagnosis, treatment and follow-up. 2014;25:iii27–iii39.

Wang G, Reed E, Li QQJO. Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer. 2004;12(5):955–65.

Hinshaw DC, Shevde LAJC. The tumor microenvironment innately modulates cancer progression. 2019;79(18):4557–66.

Wu T, Dai YJC. Tumor Microenvironment Therapeutic Response. 2017;387:61–8.

CAS  Google Scholar 

Arneth BJM. Tumor Microenvironment. 2019;56(1):15.

Google Scholar 

Micalizzi DS, Farabaugh SM. Ford HLJJomgb, neoplasia. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. 2010;15:117–34.

Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, et al. Mol Charact Tumor Microenvironment Breast cancer. 2004;6(1):17–32.

CAS  Google Scholar 

Pollard JWJNRC. Tumour-educated macrophages promote tumour progression and metastasis. 2004;4(1):71–8.

Welsh TJ, Green RH, Richardson D, Waller DA, O’Byrne KJ. Bradding PJJoco. Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non–small-cell lung cancer. 2005;23(35):8959-67.

Condeelis J, Pollard JWJC. Macrophages: obligate partners for tumor cell migration. Invasion Metastasis. 2006;124(2):263–6.

CAS  Google Scholar 

Su S, Liu Q, Chen J, Chen J, Chen F, He C et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. 2014;25(5):605–20.

Chen J, Yao Y, Gong C, Yu F, Su S, Chen J et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. 2011;19(4):541–55.

Weizman N, Krelin Y, Shabtay-Orbach A, Amit M, Binenbaum Y, Wong R, et al. Macrophages Mediate Gemcitabine Resist Pancreat Adenocarcinoma Upregulating Cytidine Deaminase. 2014;33(29):3812–9.

CAS  Google Scholar 

Genin M, Clement F, Fattaccioli A, Raes M, Michiels CJB. M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. 2015;15(1):1–14.

Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H et al. Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. 2011;108(30):12425–30.

Go RS, Adjei AAJJCO. Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin. 1999;17(1):409-.

Boulikas T, Vougiouka MJO. Recent clinical trials using cisplatin, carboplatin and their combination chemotherapy drugs. 2004;11(3):559–95.

Gottlieb JA, Drewinko BJCCR. Complexes Cancer Chemother. 1975;59(3):621–8.

CAS  Google Scholar 

McKeage MJJDs. Comparative adverse effect profiles of platinum drugs. 1995;13(4):228–44.

Dasari S, Tchounwou PBJE. Cisplatin cancer Therapy: Mol Mech Action. 2014;740:364–78.

CAS  Google Scholar 

Miyakawa H, Woo SK, Dahl SC, Handler JS, Kwon, HMJPotNAoS. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. 1999;96(5):2538–42.

Aramburu J, Drews-Elger K, Estrada-Gelonch A, Minguillón J, Morancho B, Santiago V et al. Regulation of the hypertonic stress response and other cellular functions by the rel-like transcription factor NFAT5. 2006;72(11):1597–604.

Woo SK, Kwon HMJI. Adaptation of kidney medulla to hypertonicity: role of the transcription factor TonEBP. 2002;215:189–202.

Han E-J, Kim HY, Lee N, Kim N-H, Yoo S-A, Kwon HM et al. Suppression of NFAT5-mediated inflammation and chronic arthritis by novel κB-binding inhibitors. 2017;18:261–73.

Choi SY, Lee-Kwon W, Kwon HMJNRN. The evolving role of TonEBP as an immunometabolic stress protein. 2020;16(6):352–64.

Kim SJ, Kim T, Choi HN, Cho EJ, Park JB, Jeon BH et al. TonEBP suppresses adipocyte differentiation via modulation of early signaling in 3T3-L1 cells. 2016;20(6):649.

O’Connor RS, Mills ST, Jones KA, Ho SN, Pavlath GKJJ. A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis. 2007;120(1):149–59.

Chen M, Sastry SK, O’Connor KLJAJoP-CP. Src kinase pathway is involved in NFAT5-mediated S100A4 induction by hyperosmotic stress in colon cancer cells. 2011;300(5):C1155–C63.

Küper C, Beck F-X, Neuhofer WJFip. NFAT5-mediated expression of S100A4 contributes to proliferation and migration of renal carcinoma cells. 2014;5:293.

Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A. Toker AJNcb. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. 2002;4(7):540-4.

Cho HJ, Yun H-J, Yang HC, Kim SJ, Kang SK, Che C et al. Prognostic significance of nuclear factor of activated T-cells 5 expression in non–small cell lung cancer patients who underwent surgical resection. 2018;226:40–7.

Tanaka T, Umesaki NJI. Regulation of the cellular subpopulation ratios of normal human endometrial stromal cells by macrophage colony-stimulating factor. 2003;11(5):617–20.

Liedert B, Materna V, Schadendorf D, Thomale J, Lage HJJID. Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin. 2003;121(1):172–6.

Holzer AK, Manorek GH, Howell SBJM. Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin. 2006;70(4):1390–4.

Mitsuuchi Y, Johnson SW, Selvakumaran M, Williams SJ, Hamilton TC, Testa JRJCR. The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel. 2000;60(19):5390–4.

Spierings D, De Vries E, Vellenga E, De Jong SJCD. Loss of drug-induced activation of the CD95 apoptotic pathway in a cisplatin-resistant testicular germ cell tumor cell line. Differentiation. 2003;10(7):808–22.

Article  CAS  Google Scholar 

Brahimi-Horn MC, Chiche J. Pouysségur JJJomm. Hypoxia cancer. 2007;85:1301–7.

Google Scholar 

Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS. Pujari VBJAoAm. Inflamm cancer. 2019;18(3):121.

Google Scholar 

Arango Duque G. Descoteaux AJFii. Macrophage cytokines: involvement in immunity and infectious diseases. 2014;5:491.

Dranoff GJNRC. Cytokines in cancer pathogenesis and cancer therapy. 2004;4(1):11–22.

Grivennikov S, Karin E, Terzic J, Mucida D, Yu G-Y, Vallabhapurapu S et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. 2009;15(2):103–13.

Ara T, Nakata R, Sheard MA, Shimada H, Buettner R, Groshen SG, et al. Critical role of STAT3 in IL-6–Mediated drug resistance in human NeuroblastomaSTAT3 in IL-6–Mediated. Drug Resist. 2013;73(13):3852–64.

CAS  Google Scholar 

Kitamura K, Seike M, Okano T, Matsuda K, Miyanaga A, Mizutani H, et al. MiR-134/487b/655 cluster regulates TGF-β–Induced epithelial–mesenchymal transition and drug resistance to Gefitinib by Targeting MAGI2 in Lung Adenocarcinoma CellsEMT and Resistance to Gefitinib by miR-134/487b/655. Cluster. 2014;13(2):444–53.

CAS  Google Scholar 

Ma L, Lan F, Zheng Z, Xie F, Wang L, Liu W et al. Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasion. 2012;11:1–11.

Wu Y, Zhou BP. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br J Cancer. 2010;102(4):639–44.

Article  CAS  Google Scholar 

Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. 2002;62(20):5930–8.

Schmall A, Al-Tamari HM, Herold S, Kampschulte M, Weigert A, Wietelmann A et al. Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer. 2015;191(4):437–47.

Zipin-Roitman A, Meshel T, Sagi-Assif O, Shalmon B, Avivi C, Pfeffer RM et al. CXCL10 promotes invasion-related properties in human colorectal carcinoma cells. 2007;67(7):3396–405.

Brand S, Olszak T, Beigel F, Diebold J, Otte JM, Eichhorst ST et al. Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and akt signaling resulting in proliferation and migration of colorectal cancer cells. 2006;97(4):709–23.

Huang C-Y, Fong Y-C, Lee C-Y, Chen M-Y, Tsai H-C, Hsu H-C et al. CCL5 increases lung cancer migration via PI3K, Akt and NF-κB pathways. 2009;77(5):794–803.

Szakács G, Annereau J-P, Lababidi S, Shankavaram U, Arciello A, Bussey KJ et al. Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. 2004;6(2):129–37.

Shukla A, Hillegass JM, MacPherson MB, Beuschel SL, Vacek PM, Pass HI et al. Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin. 2010;9(1):1–13.

Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RAJNRC. DNA repair pathways as targets for cancer therapy. 2008;8(3):193–204.

Martin LP, Hamilton TC, Schilder RJJC. Platinum resistance: the role of DNA repair pathways. 2008;14(5):1291–5.

Li W, Melton DJO. Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance. 2012;31(19):2412–22.

Shih Y-W, Chen P-S, Wu C-H, Jeng Y-F, Wang C. -JJJoa, chemistry f. α-Chaconine-reduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-κB in human lung adenocarcinoma A549 cells. 2007;55(26):11035–43.

Kwon GT, Cho HJ, Chung W-Y, Park K-K, Moon A, Park JHYJTJ. Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. 2009;20(9):663–76.

Shen K-H, Hung S-H, Yin L-T, Huang C-S, Chao C-H, Liu C-L et al. Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway. 2010;333:279–91.

Lu K-W, Chen J-C, Lai T-Y, Yang J-S, Weng S-W, Ma Y-S et al. Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2-9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways. 2011;30(5):406–15.

Babykutty S, PS P, RJ N, Kumar MS, Nair MS, Srinivas P et al. Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA‐binding activity of NF‐κB in colon cancer cells. 2012;51(6):475–90.

Eccles SA, Welch DRJTL. Metastasis: recent discoveries and novel treatment strategies. 2007;369(9574):1742–57.

Hanahan D, Weinberg RAJ. Hallm cancer. 2000;100(1):57–70.

CAS  Google Scholar 

Tellechea M, Buxadé M, Tejedor S, Aramburu J, López-Rodríguez. CJTJoI. NFAT5-regulated macrophage polarization supports the proinflammatory function of macrophages and T lymphocytes. 2018;200(1):305– 15.