Westbrook RH, Dusheiko G. Natural history of hepatitis C. J Hepatol. 2014;61(1):S158–68.

Article  Google Scholar 

World Health Organization. Initiative for vaccine research (http://www.who.int/vaccine_research/diseases/viral_cancers/en/index2.html).

Thuluvath PJ, Guidinger MK, Fung JJ, Johnson LB, Rayhill SC, Pelletier SJ. Liver transplantation in the United States, 1999–2008. Am J Transpl. 2010;10:1003–19.

Article  CAS  Google Scholar 

Backus LI, Boothroyd DB, Phillips BR, Belperio P, Halloran J, Mole LA. A sustained virologic response reduces risk of all-cause mortality in patients with hepatitis C. Clin Gastroenterol Hepatol. 2011;9(6):509. e1-516.e1.

Article  PubMed  Google Scholar 

Morgan TR, Ghany MG, Kim HY, et al. Outcome of sustained virological responders with histologically advanced chronic hepatitis C. Hepatology. 2010;52:833–44.

Article  CAS  PubMed  Google Scholar 

van der Meer AJ, Veldt BJ, Feld JJ, et al. Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis. JAMA. 2012;308:2584–93.

Article  PubMed  Google Scholar 

Spiegel BM, Younossi ZM, Hays RD, Revicki D, Robbins S, Kanwal F. Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment. Hepatology. 2005;41:790–800.

Article  PubMed  Google Scholar 

Kubo N, Furusyo N, Nakashima H, Kashiwagi K, Hayashi J. Strenuous physical labor is important as a cause of elevated alanine aminotransferase levels in Japanese patients with chronic hepatitis C viremia. Eur J Epidemiol. 2005;20:251–61.

Article  CAS  PubMed  Google Scholar 

El-Zayadi A, Selim O, Hamdy H, El-Tawil A, Badran HM, Attia M, Saeed A. Impact of cigarette smoking on response to interferon therapy in chronic hepatitis C Egyptian patients. World J Gastroenterol. 2004;10:2963–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pessione F, Ramond MJ, Njapoum C, Duchatelle V, Degott C, Erlinger S, Rueff B, Valla DC, Degos F. Cigarette smoking and hepatic lesions in patients with chronic hepatitis C. Hepatology. 2001;34:121–5.

Article  CAS  PubMed  Google Scholar 

Pol S, Marcellin P. Prise en charge de l’hépatite C en 2008. Gastroenterol Clin Biol. 2008;32:71–3.

Article  Google Scholar 

Thein H, Haber P, Dore G. Quality of life of women living with hepatitis C. J Gastroenterol Hepatol. 2003;18:841–50.

Article  Google Scholar 

Dalgard O, Egeland A, Skaug K, Vilimas K, Steen T. Health-related quality of life in active injecting drug users with and without chronic hepatitis C virus infection. Hepatology. 2004;39:74–80.

Article  PubMed  Google Scholar 

Roubenoff R, Schmitz H, Bairos L et al. Reduction of abdominal obesity in lipodystrophy associated with human immunodeficiency virus infection by means of diet and exercise: case report and proof of principle CID 2002 ; 34 : 390–3.

Mannerkorpi K, Iversen M. Physical exercise in fibromyalgia and related syndromes Brest. Pract Res Clin Rheumatol. 2003;17:629–47.

Article  Google Scholar 

Haykowsky MJ, Liang Y, Pechter D, Jones LW, McAlister FA, Clark AM. A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: the benefit depends on the type of training performed. J Am Coll Cardiol. 2007;49:2329–36.

Article  PubMed  Google Scholar 

Harrison SA, Day CP. Benefits of lifestyle modification in NAFLD. Gut. 2007;56:1760–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sørensen JB, Kragstrup J, Kjaer K, Puggaard L. Exercise on prescription: trial protocol and evaluation of outcomes. BMC Health Serv Res. 2007;7:36.

Article  PubMed  PubMed Central  Google Scholar 

Gapinski MA, Zucker DM. Factors influencing the development of a hepatitis C exercise protocol: a literature review. Gastroenterol Nurs. 2005;28:S10–8.

Article  PubMed  Google Scholar 

Payen JL, Pillard F, Mascarell V, Rivière D, Couzigou P, Kharlov N. Is physical activity possible and beneficial for patients with hepatitis C receiving pegylated interferon and Ribavirin therapy? Gastroenterol Clin Biol. 2009;33(1 Pt 1):8–14.

Article  CAS  PubMed  Google Scholar 

Barbaro G, Di Lorenzo G, Soldini M, et al. Hepatic glutathione deficiency in chronic hepatitis C: quantitative evaluation in patients who are HIV positive and HIV negative and correlations with plasmatic and lymphocytic concentrations and with the activity of the liver disease. Am J Gastroenterol. 1996;91(12):2569–73.

CAS  PubMed  Google Scholar 

Zhang JF, Fu WM, He ML, et al. MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling. RNA Biol. 2011;8:829–38.

Article  CAS  PubMed  Google Scholar 

Wan G, Xie W, Liu Z, et al. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014;10:70–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chekulaeva M, Filipowicz W. Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. Curr Opin Cell Biol. 2009;21:452–60.

Article  CAS  PubMed  Google Scholar 

Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654–9.

Article  CAS  PubMed  Google Scholar 

Mitchell PS, Parkin RK, Kroh EM et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl Acad Sci USA. 2008; 105: 10513–10518.

Mall C, Rocke DM, Durbin-Johnson B, et al. Stability of miRNA Ihuman urine supports its biomarker potential. Biomark Med. 2013;7:623–31.

Article  CAS  PubMed  Google Scholar 

Zhou Q, Li M, Wang X, et al. Immune-related microRNAs are abundant in breast milk exosomes. Int J Biol Sci. 2012;8:118–23.

Article  CAS  PubMed  Google Scholar 

Kozomara A, Griffiths-Jones S, miRBase. Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 2014;42:D68–73.

Article  CAS  PubMed  Google Scholar 

Zhou R, O’Hara SP, Chen XM. MicroRNA regulation of innate immune responses in epithelial cells. Cell Mol Immunol. 2011;8:371–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shwetha S, Gouthamchandra K, Chandra M, et al. Circulating miRNA profile in HCV infected serum: novel insight into pathogenesis. Sci Rep. 2013;3:1555.

Article  PubMed  PubMed Central  Google Scholar 

Lagos-Quintana M, Rauhut R, Yalcin A, et al. Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002;12:735–9.

Article  CAS  PubMed  Google Scholar 

Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science. 2005;309:1577–81.

Article  CAS  PubMed  Google Scholar 

Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, Wang TJ, Chan S. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol. 2011;589:3983–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laterza OF, Lim L, Garrett-Engele PW, et al. Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin Chem. 2009;55:1977–83.

Article  CAS