Germline data from oncological patients from TCGA were obtained from Huang et al [18]. Somatic mutations were obtained from the Multicenter Mutation Calling in Multiple Cancers (MC3) project [30], LOH was obtained from Taylor et al [29] and cosmic signatures were obtained from mSignatureDB [27]. Germline allele frequencies from exome non-cancer samples from gnomAD v2.1.1 were obtained using ANNOVAR [19].