Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells

Azambuja JH, Gelsleichter NE, Beckenkamp LR, Iser IC, Fernandes MC, Figueiró F, Battastini AMO, Scholl JN, De Oliveira FH, Spanevello RM, Sévigny J, Wink MR, Stefani MA, Teixeira HF, Braganhol E (2019) CD73 downregulation decreases in vitro and in vivo glioblastoma growth. Mol Neurobiol 56:3260–3279. https://doi.org/10.1007/s12035-018-1240-4

Article  PubMed  CAS  Google Scholar 

Azpiazu D, Gonzalo S, Villa-Bellosta R (2019) Tissue non-specific alkaline phosphatase and vascular calcification: a potential therapeutic target. CCR 15:91–95. https://doi.org/10.2174/1573403X14666181031141226

Article  CAS  Google Scholar 

Blackburn MR, Kellems RE (2005) Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation. In: Adv Immunol Elsevier, pp. 1–41. https://doi.org/10.1016/S0065-2776(04)86001-2

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254. https://doi.org/10.1016/0003-2697(76)90527-3

Article  PubMed  CAS  Google Scholar 

Burnstock G, Knight GE (2004) Cellular distribution and functions of p2 receptor subtypes in different systems. In: Int Rev Cytol Elsevier, pp. 31–304. https://doi.org/10.1016/S0074-7696(04)40002-3

Burnstock G, Verkhratskiĭ AN (2012) Purinergic signalling and the nervous system. Springer, Heidelberg

Book  Google Scholar 

Carr S, Smith C, Wernberg J (2020) Epidemiology and risk factors of melanoma. Surg Clin North Am 100:1–12. https://doi.org/10.1016/j.suc.2019.09.005

Article  PubMed  Google Scholar 

Chen S, Wainwright DA, Wu JD, Wan Y, Matei DE, Zhang Y, Zhang B (2019) CD73: an emerging checkpoint for cancer immunotherapy. Immunotherapy 11:983–997. https://doi.org/10.2217/imt-2018-0200

Article  PubMed  PubMed Central  CAS  Google Scholar 

Da Silva GB, Manica D, Da Silva AP, Marafon F, Moreno M, Bagatini MD (2023) Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells. Chem Biol Interact 375:110427. https://doi.org/10.1016/j.cbi.2023.110427

Article  PubMed  CAS  Google Scholar 

da Silva GB, Yamauchi MA, Zanini D, Bagatini MD (2022) Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling. Purinergic Signalling 18:61–81. https://doi.org/10.1007/s11302-021-09821-7

Article  PubMed  CAS  Google Scholar 

Di Virgilio F (2012) Purines, Purinergic Receptors, and Cancer. Cancer Res 72:5441–5447. https://doi.org/10.1158/0008-5472.CAN-12-1600

Article  PubMed  CAS  Google Scholar 

Di Virgilio F, Adinolfi E (2017) Extracellular purines, purinergic receptors and tumor growth. Oncogene 36:293–303. https://doi.org/10.1038/onc.2016.206

Article  PubMed  CAS  Google Scholar 

Forte G, Sorrentino R, Montinaro A, Luciano A, Adcock IM, Maiolino P, Arra C, Cicala C, Pinto A, Morello S (2012) Inhibition of CD73 Improves B cell-mediated anti-tumor immunity in a mouse model of melanoma. J Immunol 189:2226–2233. https://doi.org/10.4049/jimmunol.1200744

Article  PubMed  CAS  Google Scholar 

Gao Z, Dong K, Zhang H (2014) The Roles of CD73 in cancer. Biomed Res Int 2014:1–9. https://doi.org/10.1155/2014/460654

Article  CAS  Google Scholar 

Gasque P, Jaffar-Bandjee MC (2015) The immunology and inflammatory responses of human melanocytes in infectious diseases. J Infect 71:413–421. https://doi.org/10.1016/j.jinf.2015.06.006

Article  PubMed  Google Scholar 

Ghasemzadeh Rahbardar M, Hosseinzadeh H (2020) Effects of rosmarinic acid on nervous system disorders: an updated review. Naunyn-Schmiedeberg’s Arch Pharmacol 393:1779–1795. https://doi.org/10.1007/s00210-020-01935-w

Article  CAS  Google Scholar 

Han Y-H, Kee J-Y, Hong S-H (2018) Rosmarinic acid activates ampk to inhibit metastasis of colorectal cancer. Front Pharmacol 9:68. https://doi.org/10.3389/fphar.2018.00068

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hwang S-Y, Chae J-I, Kwak A-W, Lee M-H, Shim J-H (2020) Alternative options for skin cancer therapy via regulation of AKT and related signaling pathways. IJMS 21:6869. https://doi.org/10.3390/ijms21186869

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jang Y-G, Hwang K-A, Choi K-C (2018) Rosmarinic acid, a component of rosemary tea, induced the cell cycle arrest and apoptosis through modulation of HDAC2 expression in prostate cancer cell lines. Nutrients 10:1784. https://doi.org/10.3390/nu10111784

Article  PubMed  PubMed Central  CAS  Google Scholar 

Karthikkumar V, Sivagami G, Viswanathan P, Nalini N (2015) Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats. J Basic Clin Physiol Pharmacol 26. https://doi.org/10.1515/jbcpp-2014-0044

Kim T-H, Bormate KJ, Custodio RJP, Cheong JH, Lee BK, Kim HJ, Jung Y-S (2022) Involvement of the adenosine A1 receptor in the hypnotic effect of rosmarinic acid. Biomed Pharmacother 146:112483. https://doi.org/10.1016/j.biopha.2021.112483

Article  PubMed  CAS  Google Scholar 

Le Poole IC, Mutis T, van den Wijngaard RM, Westerhof W, Ottenhoff T, de Vries RR, Das PK (1993) A novel, antigen-presenting function of melanocytes and its possible relationship to hypopigmentary disorders. J Immunol 151:7284–7292

Article  PubMed  Google Scholar 

Lu C, Kerbel RS (1993) Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression. J Cell Biol 120:1281–1288. https://doi.org/10.1083/jcb.120.5.1281

Article  PubMed  CAS  Google Scholar 

Lunkes GI, Lunkes D, Stefanello F, Morsch A, Morsch VM, Mazzanti CM, Schetinger MRC (2003) Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies. Thromb Res 109:189–194. https://doi.org/10.1016/S0049-3848(03)00178-6

Article  PubMed  CAS  Google Scholar 

Luo C, Zou L, Sun H, Peng J, Gao C, Bao L, Ji R, Jin Y, Sun S (2020) A Review of the anti-inflammatory effects of rosmarinic acid on inflammatory diseases. Front Pharmacol 11:153. https://doi.org/10.3389/fphar.2020.00153

Article  PubMed  PubMed Central  CAS  Google Scholar 

Maldonado PA, Negrini LA, Ethur JDS, Oliveira L, Corrêa MDC, Becker LV, Zanin RF, Morsch VM, Schetinger MRC (2010) Nucleotide degrading enzymes in platelets from uterine cervical neoplasia patients treated with conization or radiotherapy. Biomed Pharmacother 64:499–504. https://doi.org/10.1016/j.biopha.2010.02.007

Article  PubMed  CAS  Google Scholar 

Manica A, Da Silva AM, Cardoso AM, Moreno M, Leal DB, Dutra Da Silva A, Schetinger MRC, Morsch VMM, Bagatini MD (2018) High levels of extracellular ATP lead to chronic inflammatory response in melanoma patients. J Cell Biochem 119:3980–3988. https://doi.org/10.1002/jcb.26551

Article  PubMed  CAS  Google Scholar 

Markovic SN, Erickson LA, Rao RD, McWilliams RR, Kottschade LA, Creagan ET, Weenig RH, Hand JL, Pittelkow MR, Pockaj BA, Bardia A, Vachon CM, Schild SE, Laman SD, Maples WJ, Pulido JS, Cameron JD (2007) Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc 82:364–380. https://doi.org/10.4065/82.3.364

Article  PubMed  Google Scholar 

Messeha SS, Zarmouh NO, Asiri A, Soliman KFA (2020) Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. Eur J Pharmacol 885:173419. https://doi.org/10.1016/j.ejphar.2020.173419

Article  PubMed  PubMed Central  CAS  Google Scholar 

Michielin O, Van Akkooi ACJ, Ascierto PA, Dummer R, Keilholz U (2019) Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 30:1884–1901. https://doi.org/10.1093/annonc/mdz411

Article  PubMed  CAS 

留言 (0)

沒有登入
gif