2023 Alzheimer’s disease facts and figures. Alzheimer’s Dement. Alzheimers Dement; 2023;19:1598–695.
Rajan KB, Weuve J, Barnes LL, McAninch EA, Wilson RS, Evans DA. Population estimate of people with clinical Alzheimer’s disease and mild cognitive impairment in the United States (2020–2060). Alzheimer’s Dement Alzheimers Dement. 2021;17:1966–75.
Corder E, Saunders A, Strittmatter W, Schmechel D, Gaskell P, Small G, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Sci (80-). 1993;261:921–3.
Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet Nat Genet. 2007;39:17–23.
Article CAS PubMed Google Scholar
Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet Nat Genet. 1994;7:180–4.
Article CAS PubMed Google Scholar
Roses AD, Saunders AM, Corder EH, Pericak-Vance MA, Han SH, Einstein G, et al. Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer’s disease. Arzneimittelforschung. Arzneimittelforschung; 1995. pp. 413–7.
Fleisher AS, Chen K, Liu X, Roontiva A, Thiyyagura P, Ayutyanont N, et al. Using positron emission tomography and florbetapir F 18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease. Arch Neurol Arch Neurol. 2011;68:1404–11.
Resnick SM, Bilgel M, Moghekar A, An Y, Cai Q, Wang MC, et al. Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts. Neurobiol Aging. 2015;36:2333–9.
Article CAS PubMed PubMed Central Google Scholar
Bilgel M, An Y, Zhou Y, Wong DF, Prince JL, Ferrucci L, et al. Individual estimates of age at detectable amyloid onset for risk factor assessment. Alzheimer’s Dement Alzheimers Dement. 2016;12:373–9.
Jack CR, Wiste HJ, Weigand SD, Rocca WA, Knopman DS, Mielke MM, et al. Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study. Lancet Neurol Lancet Neurol. 2014;13:997–1005.
Bateman RJ, Xiong C, Benzinger TLS, Fagan AM, Goate A, Fox NC, et al. Clinical and biomarker changes in dominantly inherited Alzheimer’s Disease. N Engl J Med N Engl J Med. 2012;367:795–804.
Article CAS PubMed Google Scholar
Belloy ME, Andrews SJ, Le Guen Y, Cuccaro M, Farrer LA, Napolioni V, et al. APOE genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry. JAMA Neurol JAMA Neurol. 2023;80:1284–94.
Hayden KM, Gaussoin SA, Hunter JC, Manson JAE, Sachs BC, Shadyab AH, et al. Cognitive resilience among APOE ε4 carriers in the oldest old. Int J Geriatr Psychiatry Int J Geriatr Psychiatry. 2019;34:1833–44.
Kaup AR, Nettiksimmons J, Harris TB, Sink KM, Satterfield S, Metti AL, et al. Cognitive resilience to apolipoprotein E ε4: contributing factors in black and white older adults. JAMA Neurol JAMA Neurol. 2015;72:340–8.
McDermott KL, McFall GP, Andrews SJ, Anstey KJ, Dixon RA. Memory resilience to Alzheimer’s genetic risk: Sex effects in Predictor profiles. Journals gerontol - ser B Psychol Sci Soc Sci. J Gerontol B Psychol Sci Soc Sci. 2017;72:937–46.
Shumaker SA, Legault C, Kuller L, Rapp SR, Thal L, Lane DS, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: women’s Health Initiative Memory Study. JAMA JAMA. 2004;291:2947–58.
Article CAS PubMed Google Scholar
Anderson GL, Limacher M. Effects of Conjugated Equine Estrogen in Postmenopausal Women with Hysterectomy: the women’s Health Initiative Randomized Controlled Trial. J Am Med Assoc JAMA. 2004;291:1701–12.
Espeland MA, Rapp SR, Shumaker SA, Brunner R, Manson JAE, Sherwin BB, et al. Conjugated equine estrogens and global cognitive funtion in postmenopausal women: women’s Health Initiative Memory Study. JAMA JAMA. 2004;291:2959–68.
Article CAS PubMed Google Scholar
Hayden KM, Beavers DP, Steck SE, Hebert JR, Tabung FK, Shivappa N, et al. The association between an inflammatory diet and global cognitive function and incident dementia in older women: the women’s Health Initiative Memory Study. Alzheimer’s Dement Alzheimers Dement. 2017;13:1187–96.
Howie B, Fuchsberger C, Stephens M, Marchini J, Abecasis GR. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet Nat Genet. 2012;44:955–9.
Article CAS PubMed Google Scholar
Qin W, Li W, Wang Q, Gong M, Li T, Shi Y et al. Race-Related Association between APOE Genotype and Alzheimer’s Disease: a systematic review and Meta-analysis. J. Alzheimer’s Dis. J Alzheimers Dis; 2021. pp. 897–906.
Shumaker SA, Reboussin BA, Espeland MA, Rapp SR, McBee WL, Dailey M, et al. The women’s Health Initiative Memory Study (WHIMS): a trial of the effect of estrogen therapy in preventing and slowing the progression of dementia. Control Clin Trials Elsevier Inc. 1998;19:604–21.
Gaussoin SA, Espeland MA, Beavers DP, Casanova R, Garcia KR, Snively BM, et al. Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants. Int J Geriatr Psychiatry Int J Geriatr Psychiatry. 2019;34:1403–11.
Assarsson E, Lundberg M, Holmquist G, Björkesten J, Thorsen SB, Ekman D et al. Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability. PLoS One PLoS One; 2014;9.
Duggan MR, Butler L, Peng Z, Daya GN, Moghekar A, An Y et al. Plasma proteins related to inflammatory diet predict future cognitive impairment. Mol Psychiatry Mol Psychiatry; 2023.
Katz DH, Robbins JM, Deng S, Tahir UA, Bick AG, Pampana A et al. Proteomic profiling platforms head to head: leveraging genetics and clinical traits to compare aptamer- and antibody-based methods. Sci Adv Sci Adv; 2022;8.
Sun BB, Chiou J, Traylor M, Benner C, Hsu Y-HH, Richardson TG, et al. Plasma proteomic associations with genetics and health in the UK Biobank. Nat Nat. 2023;622:329–38.
Levey AS, Stevens LA, Schmid CH, Zhang Y, Castro AF, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med Am Coll Physicians. 2009;150:604–12.
Wilkinson T, Schnier C, Bush K, Rannikmäe K, Henshall DE, Lerpiniere C, et al. Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data. Eur J Epidemiol Eur J Epidemiol. 2019;34:557–65.
Breiman L. Random Forest. Mach Learn. 2001;45:5–32.
Yang C, Farias FHG, Ibanez L, Suhy A, Sadler B, Fernandez MV, et al. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. Nat Neurosci Nat Neurosci. 2021;24:1302–12.
Article CAS PubMed Google Scholar
Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, et al. Association analyses of east Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Hum Mol Genet Hum Mol Genet. 2017;26:1770–84.
Article CAS PubMed Google Scholar
Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, et al. A large electronic-health-record-based genome-wide study of serum lipids. Nat Genet Nat Genet. 2018;50:401–13.
Article CAS PubMed Google Scholar
de Wolf F, Ghanbari M, Licher S, McRae-McKee K, Gras L, Weverling GJ, et al. Plasma tau, neurofilament light chain and amyloid-b levels and risk of dementia; a population-based cohort study. Brain Brain. 2020;143:1220–32.
Mattsson N, Andreasson U, Zetterberg H, Blennow K, Weiner MW, Aisen P, et al. Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease. JAMA Neurol JAMA Neurol. 2017;74:557–66.
Roses AD. Apolipoprotein E alleles as risk factors in Alzheimer’s disease. Annu Rev Med Annu Rev Med; 1996. pp. 387–400.
Burnham SC, Laws SM, Budgeon CA, Doré V, Porter T, Bourgeat P, et al. Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiol Aging Neurobiol Aging. 2020;95:46–55.
Article CAS PubMed Google Scholar
Betthauser TJ, Bilgel M, Koscik RL, Jedynak BM, An Y, Kellett KA, et al. Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts. Brain Brain. 2022;145:4065–79.
Toledo JB, Habes M, Sotiras A, Bjerke M, Fan Y, Weiner MW, et al. APOE effect on Amyloid-β PET spatial distribution, deposition rate, and Cut-Points. J Alzheimer’s Dis. J Alzheimers Dis. 2019;69:783–93.
留言 (0)